Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06615206Recruiting
First CRISPR RNA therapy for MECP2 duplication syndrome
This trial tests a new CRISPR therapy that edits RNA to treat a rare genetic condition called MECP2 duplication syndrome (MDS). It is for boys aged 2 to 18 who have stable seizures and no other major health problems, with the goal of improving symptoms and safety.
Beijing, Beijing MunicipalityAges 2–18 - NCT05875311Recruiting
Check-in monitoring for people with chronic coronary disease
This trial tests a phone/remote monitoring system to help keep regular follow-ups (“continuity of care”) for people with chronic coronary syndrome after a recent heart event. It may help your care team spot problems earlier and adjust treatment sooner.
ValenciaAges 18–72 - NCT05805566Recruiting
Study of care for long COVID symptoms in adults
This study follows people who enter a specialized care pathway for long COVID (post-COVID syndrome) to better understand symptoms, needs, and outcomes. It may help improve how multidisciplinary care is organized for long COVID over time.
Pierre-BéniteAges 18 years+ - NCT05528900Recruiting
Study of children with acute food-triggered gut reactions
This study follows children (from birth to age 17) who have been diagnosed with acute food protein–induced enterocolitis syndrome (FPIES). Doctors want to better understand this condition after a suspected reaction to food, using either symptom-based diagnosis or a supervised food challenge when needed.
AngersAges Up to 17 years - NCT07747259Recruiting
Core stability and quality of life in active women with polyendocrine metabolic ovarian syndrome
This study compares core stability, body awareness, pelvic health, sleep, and quality of life between physically active women with and without polyendocrine metabolic ovarian syndrome (PMOS). It aims to understand how this condition affects these areas, which may help guide future treatments.
IstanbulAges 18–40 - NCT07749066Recruiting
Laser treatment for hip pain
This study tests a high-intensity laser treatment to reduce hip pain and improve function in people with greater trochanteric pain syndrome (pain on the outside of the hip). It may help if you've had hip pain for at least 3 months and haven't had recent injections or other conservative treatments.
Ankara, YenimahalleAges 18–80 - NCT07750288Recruiting
Understanding breathing difficulty in children with lung injury
This study looks at how severe breathing difficulty (dyspnea) affects the recovery of children with a lung condition called acute respiratory distress syndrome (ARDS). It aims to improve care by tracking symptoms over time.
SantiagoAges 1 month–18 years - NCT07555171Enrolling by invitation
Brain Wave Changes During Fenfluramine Treatment in Lennox-Gastaut Syndrome
This study tracks how brain wave patterns change when children and young adults with Lennox-Gastaut Syndrome (a severe seizure disorder) take fenfluramine, a medication that helps reduce drop seizures. Researchers will use EEG (brain wave recordings) to understand how this treatment affects the brain.
Chicago, IllinoisAges 2–35 - NCT05374824Recruiting
Palliative surgery versus more seizure medicines for Lennox-Gastaut
This trial compares two treatment approaches for children with Lennox-Gastaut syndrome: palliative (comfort-focused) surgery versus adding more anti-seizure medicines. It aims to see which option works better for seizure control and day-to-day well-being.
Chicago, IllinoisAges Up to 26 years - NCT05002478Recruiting
Prone positioning for very sick babies with lung distress
This trial tests whether turning very sick, ventilated infants onto their stomach (prone positioning) can improve breathing when they have severe lung distress from likely pneumonia or bronchiolitis. It may help your baby get better oxygen levels and recover faster, while doctors closely monitor safety.
ViennaAges Up to 1 year - NCT06421506Recruiting
Giving surfactant through a thin tube in late preterm babies
This trial tests a less invasive way to give surfactant (a lung treatment) to babies born a few weeks early who need breathing help. It aims to see if this method works as well as standard care.
LondonAges 8 months–9 months - NCT07573527Recruiting
Online therapy for upper back muscle pain from trigger points
This study tests whether remote physical therapy (done online) can help relieve neck and upper back pain caused by tight knots in your rhomboid muscles. You would receive guided exercises and treatment through video calls instead of visiting a clinic in person.
Karachi, SindhAges 18–35 - NCT07087314RecruitingPhase 2
Study of an injection for nephrotic syndrome in children
This study tests an injection (SG301) that targets a protein called CD38 to help children whose nephrotic syndrome keeps coming back or depends on steroids. The goal is to see if the treatment can reduce relapses and the need for steroids.
Hangzhou, ZhejiangAges 6–18 - NCT07082712Recruiting
Thyroid issues and heart attack link study
This study looks at whether thyroid problems are connected to heart attacks (acute coronary syndrome). It may help explain why some people have heart issues.
SohagAges 20 years+ - NCT06926205RecruitingPhase 2
CHOP chemo plus mosunetuzumab for Richter's syndrome first treatment
This trial tests a new immunotherapy drug (mosunetuzumab) combined with standard chemotherapy (CHOP) as the first treatment for Richter's syndrome, a fast-growing lymphoma that can arise from CLL. The goal is to see if this combination helps control the disease better than standard therapy.
Barcelona, BarcelonaAges 18–79 - NCT06786728Enrolling by invitation
Ultrasound-guided fluid removal for kidney recovery in heart-kidney syndrome
This study tests if using ultrasound scans to guide fluid removal helps protect kidney function in people with cardiorenal syndrome type 1, where heart failure suddenly worsens kidney function.
CairoAges 18–65 - NCT06777160Recruiting
Predicting bone cement risks with AI
This study uses artificial intelligence to predict a rare but serious reaction called bone cement implantation syndrome during hip and knee replacement surgeries. It may help doctors better prepare and protect you.
ErzurumAges 18 years+ - NCT06656182Recruiting
Mobilization techniques for scapulocostal syndrome
This trial tests two types of gentle joint movements (SNAGs and scapular mobilizations) to see if they reduce pain and improve shoulder and neck movement in people with scapulocostal syndrome. If you have chronic neck pain and trouble lifting your arm overhead, this study may help.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT06648070Recruiting
Exercises for Upper Cross Syndrome in IT Workers
This study compares two types of physical therapy exercises to see which helps IT professionals with Upper Cross Syndrome (rounded shoulders and forward head posture) feel better. If you qualify, you'll get free treatment and help improve your posture and pain.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06612411RecruitingEarly Phase 1
Testing a probiotic for diarrhea-predominant IBS
This trial tests whether a specific probiotic (Bacillus subtilis) can help relieve symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS). The study also looks at whether the probiotic works by increasing a natural chemical called hypoxanthine in the body.
NanjingAges 16–80 - NCT06474897Recruiting
Comparing mobilization and ozone therapy for shoulder pain
This study compares two treatments—gentle movement exercises and ozone injections—for shoulder pain. It aims to see which option helps people with shoulder impingement feel better faster.
ElâzığAges 18–65 - NCT06696261RecruitingPhase 3
Lianxiaxiaopi granules for post-meal fullness
This study tests a Chinese herbal granule (Lianxiaxiaopi) for people with postprandial distress syndrome, a condition where you feel full too soon or uncomfortably full after eating. The goal is to see if it helps reduce these symptoms.
Beijing, Beijing MunicipalityAges 18–65 - NCT05662111RecruitingPhase 2
Etidronate treatment for brain calcifications in Fahr disease
This Phase 2 study tests whether etidronate (a medicine that affects bone-calcium handling) can help people with Fahr disease or a similar condition marked by calcium deposits in the brain. It will also check safety and whether certain tests can track changes over time.
Utrecht, UtrechtAges 18 years+ - NCT05672901Recruiting
Silicone gel vs estrogen cream for menopause discomfort
This study compares a silicone gel with an estrogen vaginal cream to treat genital and urinary symptoms caused by menopause. It may help you see which treatment works better and is more comfortable for your symptoms.
Laguna Hills, CaliforniaAges 18 years+
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,195 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.