Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06079788RecruitingPhase 3
ACTH for children with frequently relapsing nephrotic syndrome
This trial tests if a hormone called ACTH can help children with nephrotic syndrome who have frequent relapses or need steroids to stay in remission. It aims to find a treatment that may reduce the need for steroids and prevent relapses.
Wuhan, HubeiAges 2–14 - NCT01257269Recruiting
Study of genetic and blood features in Upshaw-Schulman
This study looks at how genetic changes (ADAMTS13 gene mutations) and blood test results relate to symptoms and treatment needs in Upshaw-Schulman syndrome. It may help doctors better predict disease behavior and personalize care.
Oklahoma City, OklahomaAges Any age - NCT05756023Recruiting
IVF and ICSI outcomes in women with PCOS
This trial studies how IVF (fertility treatment) and ICSI (a lab step used with IVF) work in women with PCOS. It may help doctors understand which PCOS-related factors affect success and how to tailor care.
AsyutAges 20–35 - NCT06053554Recruiting
Comparing two cataract surgery methods for pseudoexfoliation
This study compares two different surgical methods for placing a new artificial lens (IOL) during cataract surgery in people with pseudoexfoliation syndrome. It aims to find which method works best for these patients.
ViennaAges 60–100 - NCT06104696Recruiting
Comprehensive Geriatric Assessment in Kidney Transplant Patients Over 60
This study looks at how a full health review (geriatric assessment) can help older adults who are getting or have gotten a new kidney. It aims to improve care and outcomes for patients aged 60 and over.
PragueAges 60 years+ - NCT02438085Recruiting
Registry study of acute chest pain heart events in Ferrara
This study records information about heart problems that require hospital care, such as acute coronary syndromes. It helps researchers understand how these events happen in the Ferrara area and what care people receive.
Cona, FerraraAges 18 years+ - NCT03185702Recruiting
Turner syndrome research registry for people with Turner syndrome
This registry study is collecting information from people who have Turner syndrome. It may help researchers better understand the condition and plan future studies that could lead to improved care.
Houston, TexasAges Any age - NCT03137355Recruiting
Registry for people with Leigh syndrome
This study is a registry that collects information from people diagnosed with Leigh syndrome. It may help researchers understand the condition better and improve future care.
Houston, TexasAges birth–100 years - NCT06167135Recruiting
PCOS, Insulin Resistance, and Fertility Study
This study looks at how polycystic ovary syndrome (PCOS) and insulin resistance (a condition where your body doesn't use insulin well) are linked to energy problems in cells (mitochondrial dysfunction). It aims to understand how these conditions affect fertility in women.
BudapestAges 20–45 - NCT07854119Recruiting
Exercise with and without hands-on therapy for upper crossed syndrome
This trial compares two types of physical therapy—one using exercises alone and the other adding a hands-on technique called positional release—to see which better relieves neck pain and improves posture in people with upper crossed syndrome.
Lahore, Punjab ProvinceAges 20–40 - NCT05726916RecruitingPhase 3
Eculizumab for severe kidney and blood clotting emergencies in adults
This trial studies eculizumab, a targeted blood-clotting and immune system medicine, for adults hospitalized with hypertensive emergency–associated hemolytic uremic syndrome (a serious condition affecting kidneys and blood). It aims to see whether the drug can improve outcomes after this life-threatening event.
ParisAges 18 years+ - NCT06198842RecruitingPhase 2
Low-dose treosulfan with PTCy for Nijmegen Breakage Syndrome transplant
This trial tests a low-dose chemotherapy regimen (treosulfan) combined with a drug called PTCy to prepare children with Nijmegen Breakage Syndrome for a stem cell transplant. The goal is to reduce side effects while helping the donor cells take hold safely.
MoscowAges 3 months–21 years - NCT07866859Recruiting
Leg ultrasound to predict heart pressure
This study checks if a leg ultrasound can help doctors estimate the pressure in your heart's main pumping chamber before a heart procedure. If it works, it could give useful information without extra tests.
Chon BuriAges 18–100 - NCT06061562Recruiting
Sleep Apnea and Activity in Down Syndrome
This trial looks at whether physical activity can help improve sleep apnea in people with Down syndrome. It aims to find better ways to manage breathing problems during sleep.
La TroncheAges 6 years+ - NCT05809323Recruiting
Trial testing moderate exercise in teens with Marfan syndrome
This trial studies whether doing moderate exercise is safe and helpful for people with Marfan syndrome. It aims to see how exercise affects heart and health measures, like how the aorta and body respond over time.
Houston, TexasAges 10–25 - NCT06222255Recruiting
Transanal irrigation for sleep issues after rectal cancer surgery
This trial tests if a special irrigation technique can improve sleep problems caused by low anterior resection syndrome (LARS) after rectal cancer surgery. It may help people who have ongoing bowel symptoms that disrupt sleep.
Seoul, Jongro-guAges 19–80 - NCT05204459Recruiting
MRI and eye-scan study for MS and related conditions
This trial uses brain MRI and eye imaging tests to study research markers in people with multiple sclerosis (MS) and related neurologic conditions. It may help researchers better understand these diseases and how they change over time.
Los Angeles, CaliforniaAges 18 years+ - NCT07872514Enrolling by invitation
Personalized probiotics for irritable bowel syndrome
This study tests whether a probiotic treatment designed specifically for you can help ease your irritable bowel syndrome (IBS) symptoms. If you make it into the study, you'll get a treatment plan tailored to your gut and your symptoms.
Hamilton, OntarioAges 18–70 - NCT05281445Recruiting
Studying hormones in children with Tourette syndrome
This study looks at whether certain hormones (called neuroactive steroids) are related to Tourette syndrome in children. It may help doctors understand the condition better and could lead to new treatments.
Salt Lake City, UtahAges 8–12 - NCT04390646RecruitingPhase 2/Phase 3
Hormone treatment to study thinking in Down syndrome
This trial studies whether a GnRH hormone treatment can improve thinking and memory in people with Down syndrome. It also checks safety and whether the treatment affects brain-related changes seen on MRI.
Lausanne, Canton of VaudAges 16–50 - NCT06030349Recruiting
Breathing support for kids with Down syndrome and sleep apnea
This trial looks at how well non-invasive breathing machines help children with Down syndrome who have obstructive sleep apnea. It tracks their health and sleep over time to see if the treatment works and improves daily life.
DublinAges 6 months–16 years - NCT06261866Recruiting
Heart imaging for moderate blockages in stable heart disease
This trial tests whether combining two advanced imaging tests (FFR and OCT) can help doctors better decide treatment for moderate blockages in heart arteries. If you have stable chest pain or a positive stress test and a moderate narrowing, this study may help guide your care.
WarsawAges 18 years+ - NCT02829684Recruiting
Register for people with Prader-Willi syndrome
This is a patient registry that collects information about people with Prader-Willi syndrome. It may help researchers better understand the condition and plan future studies.
ToulouseAges Any age - NCT07860021RecruitingPhase 2/Phase 3
Vyvgart for stiff person syndrome
This trial tests whether a drug called Vyvgart (hyaluronidase-fjjo) can help people with stiff person syndrome who still have symptoms like stiffness, painful muscle spasms, and trouble walking despite other treatments. The goal is to see if it improves these symptoms and how well it works.
Philadelphia, PennsylvaniaAges 25–80
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.