Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05672901Recruiting
Silicone gel vs estrogen cream for menopause discomfort
This study compares a silicone gel with an estrogen vaginal cream to treat genital and urinary symptoms caused by menopause. It may help you see which treatment works better and is more comfortable for your symptoms.
Laguna Hills, CaliforniaAges 18 years+ - NCT05558566Recruiting
Neurofeedback training for Tourette-related tics in teens
This study tests whether brain training using “neurofeedback” can reduce Tourette syndrome tics in children ages 10–16. It compares an active neurofeedback condition to a control condition while measuring brain activity with an MRI.
New Haven, ConnecticutAges 10–16 - NCT05545384RecruitingPhase 3
Immediate vs delayed azathioprine or rituximab for children with anti-MOG attacks
This Phase 3 trial tests whether starting anti-inflammatory treatment right away is better than waiting, using either azathioprine or rituximab, for children with anti-MOG antibody–related acute demyelinating episodes. It may help reduce future attacks and disability.
BesançonAges 6–17 - NCT05509933RecruitingPhase 3
Budesonide to prevent engraftment syndrome after stem cell transplant
This Phase 3 study tests whether budesonide can prevent “engraftment syndrome” after people receive a hematopoietic (blood-forming) stem cell transplant. If it works, it may reduce complications around the time the new cells start growing and making blood cells.
Detroit, MichiganAges 18–80 - NCT05319132Recruiting
Test a lab treatment for ROSAH syndrome using blood cells
This trial studies DF-003 in lab tests using blood immune cells taken from people with ROSAH syndrome. It aims to see whether the treatment works in lab “ex vivo” tests and could guide future options.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT05221021RecruitingPhase 4
Vaginal estrogen vs oral bladder medicine for overactive bladder
This study compares vaginal estradiol (a hormone placed in the vagina) versus an oral beta-3 medicine called mirabegron for overactive bladder symptoms. It looks to see which treatment works better and is safer for postmenopausal women.
Bethesda, MarylandAges 18 years+ - NCT06748924Recruiting
Chronic coronary syndrome snapshot study
This study looks at how well doctors follow standard guidelines when treating people with chronic coronary syndrome (a type of long-term heart disease). It may help doctors improve care for patients with chest pain, heart disease, or related conditions.
YerevanAges 18 years+ - NCT05861609Recruiting
Tapering pain meds for nerve pain after spinal cord stimulation
This study helps people with persistent nerve pain in the low back or legs who are planned to start spinal cord stimulation (SCS). It tests a careful plan to reduce (taper) opioid pain medicines using specific replacement medicines, while monitoring safety and pain control.
JetteAges 18 years+ - NCT04061421RecruitingPhase 1/Phase 2
Testing new medicine combos for bone marrow disease overlap syndromes
This early-phase trial studies a new treatment plan (decitabine-related medicine with other targeted drugs, depending on the arm) for adults with MDS/MPN overlap syndromes. It aims to improve control of the disease by targeting the abnormal bone marrow cells. Because it’s Phase 1/2, the main goal is to find safe dosing and see whether it helps responses.
Tampa, FloridaAges 18 years+ - NCT03506594Recruiting
Radiofrequency treatment for menopause-related genital symptoms
This trial studies whether a non-surgical heat-based treatment (radiofrequency) can improve genital and urinary symptoms caused by menopause. It may help if your symptoms are bothersome and you meet the study’s safety and health requirements.
Salvador, Estado de BahiaAges 45–65 - NCT02447861Recruiting
Study of behavior differences in 3q29 deletion or duplication
This study looks at how brain development and behavior may differ in people with a 3q29 deletion or 3q29 duplication. It may help researchers understand what to expect and how these conditions affect daily life.
Piscataway, New JerseyAges Any age - NCT05256160Recruiting
Study brain excitability in people with cyclic vomiting syndrome
This study looks at how sensitive your brain is (brain “excitability”) in people with cyclic vomiting syndrome (CVS). It may help researchers understand what is happening in the brain during CVS and how it could be treated in the future.
Pittsburgh, PennsylvaniaAges 18–60 - NCT01419561RecruitingPhase 2
Studying KSHV inflammatory syndrome (KICS)
This study tracks people with KICS, a condition caused by KSHV (a virus related to Kaposi sarcoma). It aims to understand the syndrome better and may lead to future treatments.
Bethesda, MarylandAges 18 years+ - NCT02863172Recruiting
Genetic studies in families with inherited colon cancer
This study looks at genetic reasons some families get colon cancer due to inherited (run-in-the-family) syndromes. It may help doctors better understand risk and tailor care for you or your relatives.
Houston, TexasAges 18 years+ - NCT03705715RecruitingPhase 1
Study brain immune-cell activity in different mental and brain conditions
This Phase 1 study looks for patterns (correlates) in how “microglial” brain immune cells become activated across different neuropsychiatric conditions and in healthy volunteers. It uses brain imaging to help researchers understand what might drive symptoms and differences between people.
Houston, TexasAges 18–80 - NCT07114055RecruitingPhase 2/Phase 3
Ebastine for diarrhea-predominant IBS
This trial tests whether ebastine, an allergy medicine, can help relieve symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D). If you have IBS-D and are at least 18, this study may offer a new option to manage your condition.
DhakaAges 18 years+ - NCT07141420Enrolling by invitation
Smartphone tool to help ICU recovery
This study tests whether a smartphone tool can help people recover from the long-term effects of being in the ICU. You might be eligible if you had a recent ICU stay and are comfortable using a smartphone.
Guiyang, GuizhouAges 18–100 - NCT03584815Recruiting
Test of physiotherapy versus surgery for exercise leg muscle pressure
This trial compares a physiotherapy program to a surgical procedure (fasciotomy) for chronic “compartment” pressure in the lower leg triggered by exercise. If you have symptoms that reliably come on with walking/running and improve with rest, the study may offer a structured way to find the best treatment for you.
Copenhagen, CopehagenAges 18–50 - NCT03681964Recruiting
Check tests for suspected Sjögren’s syndrome
This study follows people who have signs that might mean Sjögren’s syndrome and looks at how well a standardized work-up identifies the condition. It may help doctors confirm the diagnosis earlier and more consistently.
BrestAges 18 years+ - NCT02967822Recruiting
Study of genes in MRKH syndrome and related families
This study looks at DNA (your genes) to better understand Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. It may help researchers learn more about the condition, and it can include both people with MRKH and healthy family relatives.
ParisAges Any age - NCT06534853Recruiting
Stretching study for low back pain relief
This study compares two stretching techniques for a condition called quadratus lumborum syndrome, which causes low back or hip pain. Researchers want to see which type of muscle stretch works better to relieve pain and improve movement.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT06196203RecruitingPhase 2
Study of AK117 with Azacitidine for High-Risk MDS
This trial tests a new drug, AK117, combined with azacitidine for people newly diagnosed with high-risk myelodysplastic syndromes (MDS), a blood disorder. The goal is to see if the combination can help improve outcomes.
Los Angeles, CaliforniaAges 18 years+ - NCT03154697Recruiting
Study for parents of children with Smith-Magenis syndrome and sleep issues
This study builds a database about people with Smith-Magenis syndrome and their sleep problems. It wants information from the child’s parent or legal guardian to better understand sleep disturbances.
Washington D.C., District of ColumbiaAges 3–65 - NCT07629505Recruiting
CoQ10 supplement for chronic pelvic pain in men
This trial tests whether a CoQ10 supplement (Ralivia) can reduce chronic pelvic or perineal pain lasting at least 3 months. The study aims to see if this supplement helps relieve symptoms when other treatments haven't fully worked.
ThessalonikiAges 18–50
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,195 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.