Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,197 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05721742Recruiting
Virtual diet education for irritable bowel symptom management
This trial tests whether adding online (virtual) diet education to a step-by-step irritable bowel (IBS) care plan can improve symptoms like belly pain and stool changes. You may be asked to make diet changes and use a device to join the virtual education.
Halifax, N.S.Ages 18–65 - NCT05726916RecruitingPhase 3
Eculizumab for severe kidney and blood clotting emergencies in adults
This trial studies eculizumab, a targeted blood-clotting and immune system medicine, for adults hospitalized with hypertensive emergency–associated hemolytic uremic syndrome (a serious condition affecting kidneys and blood). It aims to see whether the drug can improve outcomes after this life-threatening event.
ParisAges 18 years+ - NCT05730491Recruiting
Online parenting program for kids with IBS-related belly pain
This trial tests an online social learning program to help parents support their child when the parent has irritable bowel syndrome (IBS) or related belly pain. It may help families build coping skills and resilience through guided parent sessions.
Seattle, WashingtonAges 18 years+ - NCT05731830Recruiting
Study how air pollution relates to Takotsubo heart episodes
This study looks at whether levels of air pollution are linked to Takotsubo syndrome (a temporary heart condition). It may help doctors understand what environmental factors could affect episodes and timing.
RomeAges 18 years+ - NCT05732103RecruitingPhase 1/Phase 2
Testing CTX-712 for AML or high-risk MDS after prior treatment
This early-phase study tests CTX-712, a new cancer treatment, in people whose acute myeloid leukemia (AML) or certain high-risk blood cancers came back or did not respond to prior therapy. It may help shrink the cancer and control the disease by targeting it differently than standard treatments.
Phoenix, ArizonaAges 18 years+ - NCT05734287Recruiting
Study of causes of high male-hormone signs in young women
This study looks at how common polycystic ovary syndrome (PCOS) is among young women who have “high male-hormone” symptoms. It may help doctors better understand what condition is most likely behind those symptoms in your age group.
DohaAges 15–35 - NCT05740319Recruiting
Test stool transplant to treat irritable bowel syndrome
This trial studies fecal microbiota transplantation, which is transferring stool bacteria from a healthy donor to help rebalance gut microbes. If you have irritable bowel syndrome (IBS) that hasn’t improved after several standard treatments, this study may see whether it reduces your symptoms and is safe.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05740761Recruiting
Gene editing for children with Rett syndrome
This trial tests a gene-editing approach for Rett syndrome in children who have a confirmed MECP2 gene mutation. It may help by targeting specific “hotspot” genetic changes that cause the condition.
Siena, SienaAges 6 months+ - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT05742776Recruiting
Ultrasound and sleep quality check in carpal tunnel
This trial studies whether ultrasound exam findings match how well you sleep if you have carpal tunnel syndrome. It may help doctors better understand which ultrasound results go along with worse sleep and symptoms.
Afyonkarahisar, Afyonkarahi̇sarAges 20–80 - NCT05756023Recruiting
IVF and ICSI outcomes in women with PCOS
This trial studies how IVF (fertility treatment) and ICSI (a lab step used with IVF) work in women with PCOS. It may help doctors understand which PCOS-related factors affect success and how to tailor care.
AsyutAges 20–35 - NCT05765071Recruiting
Botulinum injections for lower leg exertional muscle pressure pain
This trial studies whether injecting botulinum (a medicine that relaxes overactive muscles) into the lower leg can reduce pain and pressure during exercise in people with a confirmed condition called chronic exertional compartment syndrome. It may help by lowering the muscle compartment pressure that builds up after activity.
Calgary, AlbertaAges 18–50 - NCT05767216Recruiting
Study of genetic and epigenetic differences in twin pairs with Down syndrome
This study looks at how genetics and gene-regulation (how genes turn on and off) differ between close family members who have different Down syndrome status. Researchers hope the findings will help explain why Down syndrome outcomes can vary even in very closely related people.
ParisAges 4–11 - NCT05772611Recruiting
Study of immune responses in brain autoimmune and nerve syndromes
This study looks at how the immune system works in certain neurological conditions, including autoimmune encephalitis and related nerve disorders. Researchers may use blood and/or spinal fluid samples, especially when antibodies are present or can’t be found, to better understand what’s driving the illness.
LyonAges 18 years+ - NCT05772871RecruitingPhase 4
Prednisone plus herbal granules for children with nephrotic syndrome
This trial tests whether adding Huaiqihuang granules to prednisone can improve outcomes for children with primary, hormone-sensitive nephrotic syndrome. It also closely monitors safety to see if the combination causes fewer or more side effects than usual care.
Hefei, AnhuiAges 1.5 years–18 years - NCT05777889Recruiting
Infrared imaging for nerve-stimulation pain in one leg
This study uses infrared images to help evaluate spinal cord stimulation for complex regional pain syndrome (CRPS) when it affects one leg. It aims to see whether the imaging approach matches pain and treatment needs in people whose pain hasn’t improved with standard care.
New York, New YorkAges 18–85 - NCT05785000Recruiting
Rehab program for long-lasting concussion symptoms
This trial tests a rehabilitation approach for people with post-concussion syndrome (ongoing symptoms after a mild head injury). It may help by guiding safer, structured recovery—especially through exercise—if it fits your situation and you can participate.
Copenhagen, Region of Greater CopenhagenAges 18–70 - NCT05786235Recruiting
Pregnant people with or without antiphospholipid antibodies
This study is looking at pregnancy outcomes in people who are pregnant and either have antiphospholipid antibody syndrome (APS) or do not have APS but do have prior full-term pregnancies. It may help doctors understand risks and how to manage pregnancies in these groups.
MilanAges 18–45 - NCT05789056RecruitingPhase 2/Phase 3
Study lotion for Netherton syndrome safety and symptom improvement
This trial tests a prescription lotion (QRX003) to see if it is safe and helpful for people with Netherton syndrome. Because the study checks skin symptoms on certain body areas and closely controls other treatments, it may be best for patients who can keep their current regimen stable.
San Diego, CaliforniaAges 14 years+ - NCT05795465RecruitingPhase 2
Study drug for people with acute respiratory distress syndrome
This Phase 2 trial tests GEn-1124 to see if it can improve outcomes in people with acute respiratory distress syndrome (ARDS). You may be eligible if the study drug can be started very soon after ARDS is diagnosed and if you meet the safety and health requirements.
Washington D.C., District of ColumbiaAges 18–85 - NCT05797909Recruiting
PCOS Challenge Study: Share your experiences in a PCOS registry
This study asks people with PCOS (or PCOS-like symptoms) to join a registry and answer surveys. It helps researchers understand day-to-day experiences and needs in PCOS, which may lead to better support and care.
Bethesda, MarylandAges 12–80 - NCT05800821Recruiting
Predicting brain blood-flow problems after carotid surgery
This study uses deep learning to predict which people are at risk for “cerebral hyperperfusion syndrome” (a dangerous spike in brain blood flow) after carotid revascularization. If you qualify, they’ll use scans/tests to estimate your risk so doctors can watch you more closely if needed.
MinskAges 30–80 - NCT05803993Recruiting
Fecal transplant to ease constipation in irritable bowel syndrome
This trial tests whether transferring stool bacteria to the gut (fecal microbiota transplantation) can reduce symptoms of irritable bowel syndrome with constipation. It may help by changing the gut microbiome, but you must meet safety and health requirements.
RomaAges 18 years+ - NCT05803980Recruiting
Fecal transplant to ease IBS diarrhea symptoms
This study tests whether fecal microbiota transplantation (a stool-based treatment to change gut bacteria) can reduce symptoms of irritable bowel syndrome (IBS) that comes with diarrhea. You may be eligible if you’re an adult with diarrhea-predominant IBS and recent colonoscopy results that rule out other intestinal diseases.
RomaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,197 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.