Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06294990RecruitingPhase 4
Testosterone treatment for boys with Klinefelter syndrome in puberty
This trial tests if starting testosterone treatment during puberty (ages 10-14) helps boys with Klinefelter syndrome. It aims to understand how the hormone affects development and well-being.
CopenhagenAges 10–14 - NCT07384715RecruitingPhase 1
GEN3018 for AML or high-risk MDS
This trial tests a new drug called GEN3018 for people with acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (MDS) that has come back or not responded to standard treatments. It aims to see if the drug is safe and effective.
AarhusAges 18 years+ - NCT06758492Recruiting
Video vs direct laryngoscopy for surfactant in newborns
This study compares two ways of placing a thin tube into a newborn's windpipe to give surfactant—a medicine that helps their lungs work better. It will help doctors understand which method is safer and easier for babies needing this treatment.
RijekaAges birth–4 weeks - NCT07380594Recruiting
Study of psychiatric symptoms in White-Sutton syndrome
This study looks at mental health symptoms in people with White-Sutton syndrome, a rare genetic condition. By answering questions, you can help doctors better understand what challenges people face and how to support them.
DijonAges 6 years+ - NCT07380373Enrolling by invitation
Testing markers in body fluids for lung injury in children
This study looks at two substances in saliva and lung fluid—called IL-6 and TNF-α—in children with severe lung failure (ARDS) who are on a breathing machine. Measuring these markers may help doctors better understand the condition and guide treatment.
CairoAges 1–10 - NCT06834061Recruiting
Using ultrasound to diagnose and manage carpal tunnel syndrome
This trial tests if ultrasound can help doctors better diagnose and track carpal tunnel syndrome (a condition where a nerve in your wrist gets squeezed). It may lead to better treatment and follow-up without extra tests.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT06014775RecruitingPhase 2
Anti-CD38 Antibody for Evans syndrome
This trial tests a new drug called an anti-CD38 antibody for people with Evans syndrome, a rare condition where the immune system attacks blood cells. It is for adults whose disease is active and hasn't improved with standard treatments.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06598618Recruiting
Comparing two therapies for kneecap pain
This study compares two types of hands-on treatments—Instrument-Assisted Soft Tissue Mobilization (IASTM) and Muscle Energy Technique—to see which works better for kneecap pain. It aims to find a therapy that can help reduce your pain and improve movement.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT06707805Recruiting
Spinal gliding technique for lower cross syndrome
This trial tests a manual therapy technique called sustained natural apophyseal glides (gentle, sustained pressure on the spine) in people with low back pain caused by lower cross syndrome—a pattern where hip flexors and lower back muscles are tight while abs and buttock muscles are weak. If you have lower back pain with a forward-tilted pelvis and meet the age and muscle tightness/weakness criteria, this study may be for you.
Kotli, Azad KashmirAges 30–50 - NCT05199909RecruitingPhase 2
Testing zanubrutinib for antiphospholipid syndrome with low platelets
This Phase 2 study tests zanubrutinib, a medicine for the immune system, to treat antiphospholipid syndrome when it causes very low platelet counts. It looks at safety and whether it can improve blood clotting problems and low platelets when prior steroid treatment didn’t work well.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07369934Recruiting
Virtual reality vs. manual therapy for shoulder pain
This study compares virtual reality exercises with a hands-on therapy technique (Mulligan mobilization) to improve shoulder posture and function in people with subacromial impingement syndrome. It aims to find which approach may relieve pain and help you move better.
GizaAges 30–50 - NCT07366593Recruiting
Immune & respiratory health in Down syndrome kids with pneumonia
This study looks at how the immune system and breathing are affected in children with Down syndrome who have pneumonia. It aims to find patterns that could lead to better treatments.
CairoAges 1–6 - NCT07354438Recruiting
Antioxidant-rich diet for metabolic syndrome risk
This study tests whether eating more foods rich in antioxidants (like fruits and vegetables) can help lower your risk of metabolic syndrome, a condition that increases your chance of heart disease and diabetes. If you have a larger waist size and higher blood pressure, and you don't eat many fruits and vegetables, this trial may be a good fit.
Lahore, Punjab ProvinceAges 18–45 - NCT07356778RecruitingPhase 4
Study of sotatercept for Eisenmenger syndrome patients
This trial tests a new drug called sotatercept for people with Eisenmenger syndrome or a related heart defect that hasn't been repaired. It may help if current treatments aren't working well enough.
Fukuoka, Not Required For This CountryAges 18 years+ - NCT07356570Recruiting
Post-COVID care tracking study for long-term symptoms
This study follows people with lasting or complex COVID-19 symptoms who are already in a specialized care program. It aims to better understand and improve recovery after COVID.
Pierre-BéniteAges 18 years+ - NCT07361692Recruiting
Electric brain stimulation for complex regional pain syndrome
This trial tests if a gentle electric current applied to the scalp (called tDCS) can reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition. It aims to see if this treatment is effective and safe for managing symptoms.
Saint-NazaireAges 18 years+ - NCT06851338Recruiting
Inspire therapy study for teens with Down syndrome and sleep apnea
This study tests a device called Inspire that stimulates the airway during sleep to treat obstructive sleep apnea in teenagers with Down syndrome who cannot use a CPAP machine or had a tonsillectomy that did not work well.
Phoenix, ArizonaAges 13–18 - NCT06718179RecruitingPhase 4
Short vs. 12-month prasugrel and aspirin after a heart attack with a stent
This trial compares taking a shorter course of prasugrel (a blood thinner) plus aspirin after a heart attack versus the standard 12-month course. It aims to see if a shorter duration is just as effective and safer for people who got a specific type of stent (everolimus-eluting).
AalborgAges 18 years+ - NCT03687814Recruiting
Low FODMAP diet plus PEG for IBS with constipation
This study tests whether a low-FODMAP diet combined with PEG 3350 can reduce symptoms in adults with IBS-C (irritable bowel syndrome with constipation). It may help improve bowel habits and abdominal pain, and it checks which people can safely follow the diet and treatment plan.
Ann Arbor, MichiganAges 18 years+ - NCT06211062RecruitingPhase 2
Probiotics for chronic fatigue syndrome with IBS
This study tests whether a specific mix of probiotics can help people with chronic fatigue syndrome (ME/CFS) who also have irritable bowel syndrome (IBS). It's a small trial to see if improving gut health can ease symptoms.
Fort Lauderdale, FloridaAges 45–70 - NCT07348601RecruitingPhase 2
Study of CSTI-500 for people with Prader-Willi syndrome
This trial tests an investigational drug called CSTI-500 for people with Prader-Willi syndrome who are in the hyperphagia (constant hunger) phase. It aims to see if the drug can improve behavior and reduce overeating. You and your caregiver will need to visit the clinic regularly and answer questions about symptoms.
Nashville, TennesseeAges 13–50 - NCT07350707RecruitingPhase 1/Phase 2
PET scan for Cushing's syndrome using two tracers
This trial tests if a special PET scan using two different tracers (68Ga-Pentixafor and 68Ga-DOTATATE) can help diagnose Cushing's syndrome and find its cause. It may help doctors better understand your condition and guide treatment.
Beijing, Beijing MunicipalityAges 10–80 - NCT07349173Recruiting
Testing a new way to assess hand and arm awareness
This study explores how people perceive the space around their affected arm or hand after a condition called 'exclusion' (partial loss of awareness or use). It uses virtual reality to test this, which might lead to better therapies.
NancyAges 18 years+ - NCT07345377Enrolling by invitation
Personalized brain stimulation for irritable bowel syndrome
This study uses brain stimulation (TMS) customized for each person to treat IBS. It uses MRI scans to see how the brain responds, aiming to find better ways to predict who will benefit from this therapy.
Hangzhou, ZhejiangAges 18–75
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.