Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05535543Recruiting
Prone breathing position test for severe lung failure
This trial studies whether turning patients onto their stomach (a positioning technique called prone positioning) changes a breathing-monitoring measure in people with severe acute respiratory distress syndrome (ARDS). If you qualify, the goal is to see if this positioning can improve how well your lungs exchange oxygen while you are on a breathing machine.
IstanbulAges 18 years+ - NCT05554107Recruiting
Physical activity study for POTS symptoms
This study looks at how physical activity affects symptoms in people with POTS (a condition where heart rate rises when standing). If you have POTS, you may be asked to participate and help the researchers understand whether exercise changes how you feel.
MalmöAges 18 years+ - NCT05577754RecruitingPhase 2
Trial tests alpelisib for MCAP with PIK3CA mutations
This Phase 2 study tests alpelisib in children and adults with MCAP, a condition caused by a specific PIK3CA gene mutation. The goal is to see if the treatment is effective and safe, while carefully monitoring blood sugar and organ function.
AmiensAges 2–40 - NCT05577845Recruiting
Ramosetron vs loperamide for bowel symptoms after rectal surgery
This trial compares two medicines—ramosetron and loperamide—to see which works better for severe bowel control problems after low anterior rectal surgery. It may help people with major LARS (low anterior resection syndrome) choose a safer, more effective treatment.
Seoul, Jongro-guAges 19 years+ - NCT05578105Recruiting
Study of autoimmune polyglandular disease genetics in Taiwan
This study looks at how common autoimmune polyglandular syndrome type II is in Taiwan and what genetic differences may be involved. It uses past hospital visit records and focuses on people who had a specific pattern of autoimmune conditions.
TaipeiAges 20 years+ - NCT05581147Recruiting
Thyroid health in Klinefelter syndrome
This study looks at how the thyroid gland works and how it looks on ultrasound in people with classic (non-mosaic) 47,XXY Klinefelter syndrome. It may help doctors understand thyroid-related problems in this condition by comparing test results, symptoms, and imaging.
RomaAges 1–80 - NCT05586802RecruitingPhase 3
Balancing sex hormones to improve metabolism and fertility in Klinefelter
This study tests whether adjusting sex-hormone levels can improve body metabolism and reproductive hormone balance in people with Klinefelter syndrome. Depending on the design, you may be looking at fertility preservation and/or metabolic health.
LausanneAges 16–65 - NCT05611268Recruiting
Pentoxifylline added for Eisenmenger syndrome
This study tests whether adding pentoxifylline to usual care can improve health outcomes in people with Eisenmenger syndrome. It may help reduce problems related to blood flow and vessel function, especially for those not recently hospitalized.
São PauloAges 10–80 - NCT05628948Recruiting
Donate blood for a heart and metabolism research biobank
This study builds a “biobank,” which is a collection of blood and related samples, to support future research on heart and metabolic (sugar/body-fat) conditions. It may help researchers better understand these diseases and improve future prevention and treatments.
Cleveland, OhioAges 18 years+ - NCT05637294Recruiting
Compare night-only versus full-time splinting for carpal tunnel
This study looks at whether wearing a wrist splint only at night works as well as wearing it full-time for carpal tunnel syndrome (CTS). It may help you find the most helpful and practical splint schedule to reduce symptoms.
HelsinkiAges 18 years+ - NCT05643209Recruiting
Mapping and ablation to treat abnormal heart electrical signals
This study uses detailed 3D heart mapping to find where abnormal electrical activity starts in Brugada syndrome and then performs ablation (a targeted scar or block). It’s mainly for adults who have had concerning symptoms and already have an implanted defibrillator (ICD).
Cotignola, RavennaAges 18 years+ - NCT05651204Recruiting
Study of brain GABA signals in Dravet syndrome
This study looks at “GABA signals” in the body/brain to learn more about Dravet syndrome and how it may relate to seizures. If you have Dravet syndrome caused by a specific SCN1A gene change, you may be asked to provide genetic test results and help with study visits so researchers can compare biomarker readings.
Fort Worth, TexasAges Up to 18 years - NCT05653778Recruiting
Nerve-stimulation treatment for painful corticobasal syndrome
This trial tests “scrambler therapy,” a type of skin-based nerve stimulation, to reduce ongoing pain from corticobasal syndrome. You may be eligible if your average pain is moderate to severe and you can safely take part in the treatment schedule.
Baltimore, MarylandAges 50–89 - NCT05664412Recruiting
Brain stimulation trial to improve thinking in 22q11.2 deletion
This trial tests a non-invasive brain stimulation approach to help improve executive function—skills like planning, attention, and self-control—in people with 22q11.2 deletion syndrome. If you qualify, you would be asked to participate and allow study procedures to see whether this treatment helps.
Geneva, Canton of GenevaAges 14–25 - NCT05679206Recruiting
Postpartum care study for pregnancy blood-pressure complications
This study looks at people with preeclampsia during pregnancy and how their lung blood pressure and related symptoms change after delivery. It may help doctors better monitor and manage postpartum risks, especially involving the heart and lungs.
BernAges 16 years+ - NCT05680766Recruiting
Exercise training to improve IBS symptoms in inactive people
This trial tests whether a structured exercise program can improve symptoms in people with irritable bowel syndrome (IBS) who currently live a mostly sedentary, inactive lifestyle. It focuses on safety and feasibility (whether the program can be done and what symptom changes may occur).
JetteAges 18–60 - NCT05693909RecruitingPhase 2
SP-420 for iron overload in certain blood disorders
This Phase 2 study tests SP-420 to help people with transfusion-related iron overload from either beta-thalassemia or low-risk myelodysplastic syndromes. It aims to see if the treatment can improve how the body handles excess iron, which builds up after repeated transfusions.
CopenhagenAges 18 years+ - NCT05695963Recruiting
Daily phone check-ins for restless legs symptoms
This study uses frequent, brief check-ins (often by phone) to better understand restless legs syndrome symptoms in daily life. It may help researchers learn patterns of symptoms that could improve future care plans.
BordeauxAges 18–70 - NCT05702476Recruiting
Non-invasive 3D scan study for Marfan face features
This study uses a non-invasive 3D scan to better measure facial features in people with Marfan syndrome. It may help researchers describe face differences more accurately, without needles or surgery.
San Donato Milanese, LombardyAges Any age - NCT05703542RecruitingPhase 1
Testing BXCL701 for relapsed or resistant AML or MDS
This Phase 1 study tests BXCL701 in adults whose acute myeloid leukemia (AML) or high-blast myelodysplastic syndrome (MDS-EB-2) has come back or not responded to prior treatment. The goal is to find a safe dose and see how the treatment affects cancer cells.
Boston, MassachusettsAges 18 years+ - NCT05716880RecruitingPhase 3
Keto-like diet supplements for muscle loss in nephrotic syndrome
This Phase 3 study tests a keto-like supplement (Ketosteril) to help prevent or slow muscle loss in people with nephrotic syndrome. It may help by improving nutrition when the kidneys are leaking large amounts of protein.
Warsaw, Masovian DistrictAges 18 years+ - NCT05719246Recruiting
Yoga and meditation for teens with IBS stress
This study tests a structured yoga and meditation program to help reduce stress symptoms in teens with irritable bowel syndrome (IBS). It may help your teen learn calming practices that could ease how stress affects IBS.
Camden, New JerseyAges 12–21 - NCT05721742Recruiting
Virtual diet education for irritable bowel symptom management
This trial tests whether adding online (virtual) diet education to a step-by-step irritable bowel (IBS) care plan can improve symptoms like belly pain and stool changes. You may be asked to make diet changes and use a device to join the virtual education.
Halifax, N.S.Ages 18–65 - NCT05726916RecruitingPhase 3
Eculizumab for severe kidney and blood clotting emergencies in adults
This trial studies eculizumab, a targeted blood-clotting and immune system medicine, for adults hospitalized with hypertensive emergency–associated hemolytic uremic syndrome (a serious condition affecting kidneys and blood). It aims to see whether the drug can improve outcomes after this life-threatening event.
ParisAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,195 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.