Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,871 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04131036Recruiting
Compare emicizumab and factor VIII for joint and bone health
This study compares two preventive treatments for severe hemophilia A—emicizumab versus factor VIII—to see how they affect joint and bone health. It may help you and others understand which option better protects joints and bones over the next several years.
Los Angeles, CaliforniaAges 16 years+ - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT04141020RecruitingPhase 2
Sirolimus study for unruptured brain aneurysms after surgery
This Phase 2 study tests whether sirolimus, a medicine that changes immune and growth signals, can change what’s happening inside the tissue of unruptured brain aneurysms after a procedure. Researchers hope these molecular changes may help understand how to improve aneurysm outcomes.
Miami, FloridaAges 18 years+ - NCT04144439RecruitingPhase 4
GABA treatment for ADHD and seizures in children with epilepsy
This trial studies whether adding GABA (a substance that affects brain signaling) can help children who have both epilepsy (seizures) and ADHD. If it works, it may reduce symptoms related to either seizures, ADHD, or both.
TantaAges 4–18 - NCT04149223Recruiting
Hospital program to improve care for adults with cirrhosis
This trial tests a practical hospital-based program to improve how care is delivered to adults with cirrhosis. If you’re eligible, you may receive care that follows the trial’s improved approach and helps the team learn what works best.
Edmonton, AlbertaAges 18 years+ - NCT04152551RecruitingPhase 4
Bisphosphonate use and hearing loss in type 1 osteogenesis imperfecta
This study looks at whether bisphosphonate treatment affects hearing loss in people with type 1 osteogenesis imperfecta. If you qualify, it may help researchers understand if treatment can protect hearing over time.
New York, New YorkAges 6–100 - NCT04160455Recruiting
Study of GALIG proteins in adults with HIV on or off treatment
This study looks at how “GALIG” gene products affect the body’s internal recycling process (called autophagy) in people living with HIV. It may help researchers understand differences between people on HIV treatment, starting treatment, or not currently taking it.
OrléansAges 18 years+ - NCT04167033Recruiting
Checking heart rhythm timing in women with premature ovarian insufficiency
This study measures how quickly the heart “recharges” between beats (often shown as QT timing). It compares women with premature ovarian insufficiency to healthy women to understand whether ovarian insufficiency is linked to heart rhythm differences.
BordeauxAges 18–40 - NCT04182984Recruiting
Compare immunosuppressant medicines for eye-only myasthenia gravis
This real-world study looks at how different immunosuppressant medicines work for people with non-thymoma ocular myasthenia gravis (eye symptoms due to MG). It may help doctors understand which treatments control symptoms best in everyday care.
Xi'an, ShaanxiAges 18–75 - NCT04184479Recruiting
Test of a LEVAmethod program for adults with overweight
This study tests whether the LEVAmethod program helps adults with overweight or obesity when delivered in primary care. You may be asked to use digital tools and complete follow-up during the program.
GothenburgAges 18–75 - NCT04187820Recruiting
Acupuncture for mild to moderate Crohn’s flare
This trial tests whether acupuncture can help calm an active Crohn’s disease flare that is mild to moderate. It may be an option if standard Crohn’s medicines like steroids, immunosuppressors, and anti-TNF drugs are not working for you or you can’t tolerate them.
Shanghai, Shanghai MunicipalityAges 16–70 - NCT04192656RecruitingPhase 4
PAP treatment for sudden hearing loss with sleep apnea
This trial tests whether using PAP (a breathing device for sleep apnea) can improve sudden hearing loss that happens alongside obstructive sleep apnea. It may help by reducing stress on the body during sleep and supporting hearing recovery.
Beijing, Beijing MunicipalityAges 18–70 - NCT04192773RecruitingEarly Phase 1
Brain-scan study of IV lidocaine for tinnitus
This early study uses an MRI/brain scan to see how IV lidocaine affects brain activity in people with tinnitus, and also compares it with people without tinnitus or with different hearing patterns. It may help researchers understand whether lidocaine could change tinnitus signals in the brain.
Boston, MassachusettsAges 18 years+ - NCT04197648Recruiting
Supervised exercise study for certain thoracic aneurysms
This study looks at whether a supervised exercise program is safe and helpful for people with a thoracic (chest) aortic aneurysm. You may be able to join if your aneurysm size fits their range and you can safely attend training visits.
Québec, QuebecAges 18 years+ - NCT04199026Recruiting
Tiny implanted device delivers drugs to sarcoma tumors
This trial tests an implantable device placed during planned surgery to deliver cancer medicines directly to sarcoma tumors and study how they affect the tumors. It may be an option if your sarcoma has come back or spread and surgery is part of standard care.
Houston, TexasAges 10 years+ - NCT04201704Recruiting
Less IV fluids for children after trauma
This trial studies whether giving children less fluid through a vein after serious injury helps them recover safely. Children are enrolled soon after arrival to the ICU so the team can compare outcomes between different fluid amounts.
Buffalo, New YorkAges 6 months–15 years - NCT04209244Recruiting
Fish oil for cholesterol and side effects in ALL patients
This trial studies whether fish oil can improve cholesterol levels and reduce side effects in children and young adults with acute lymphoblastic leukemia (ALL) who are in lower-risk groups. If you fit the risk category, you may be asked to add fish oil as part of the study to see if it helps your lab results and well-being.
AalborgAges 1–45 - NCT04211753Recruiting
Mobile app support for emotional crises in borderline personality disorder
This study tests whether a smartphone app (B·RIGHT) can help people manage emotional crises related to borderline personality disorder, and checks that it is safe. If you match the diagnosis and age range, the app may be offered as part of the research.
Mataró, BarcelonaAges 18–60 - NCT04215679Recruiting
Virtual reality plus mental practice for stroke hand recovery
This trial tests whether “motor imagery” done with virtual reality can improve hand function after a stroke. You may benefit if you have readable Turkish and enough thinking ability to follow the program.
Bolu, MerkezAges 18–80 - NCT04217603Recruiting
CPAP test to improve walking distance in ECAC
This study looks at whether using CPAP (a breathing device that helps keep airways open) can improve how far you can walk in 6 minutes. It also checks how CPAP may change breathing and exercise test results in people with ECAC.
Boston, MassachusettsAges 18 years+ - NCT04218409RecruitingEarly Phase 1
Tests a spray to reduce opioid use and pain
This early trial studies whether Syntocinon can lower pain and help reduce how much opioids people use. It checks safety and the best dose by giving participants the study drug under close medical monitoring.
Gainesville, FloridaAges 21–45 - NCT04220047Recruiting
Surgery changes for preventing irregular heart rhythms during bypass
This trial studies whether removing a small heart pouch area and a specific ligament during off-pump heart bypass surgery improves outcomes. It is meant for people having their first off-pump coronary bypass, without a history of atrial fibrillation.
BeijingAges 18–80 - NCT04219709Recruiting
Study how ketosis affects brain function in adults with type 1 diabetes
This study tests whether a “ketosis” state changes brain function in adults with type 1 diabetes. You may be asked to follow specific diet/food delivery plans and use devices that track glucose, which could help researchers understand how metabolism affects the brain.
Boston, MassachusettsAges 18–40 - NCT04230421Recruiting
Smartphone treatment program for bipolar disorder
This trial is testing a smartphone-based treatment approach for people living with bipolar disorder. It may help by delivering support and care tools in a way that’s easier to use day to day.
CopenhagenAges 18 years+
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,871 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.