Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,871 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04761523Recruiting
Diet fat changes to help prevent pancreatitis coming back
This study looks at whether changing how much dietary fat you eat can lower the chance that pancreatitis returns. It focuses on people who have had pancreatitis more than once and are not already receiving specific meal guidance for a medical reason.
BudapestAges 14 years+ - NCT04773691Recruiting
High-frequency brain stimulation to help cut alcohol use
This trial tests whether high-frequency rTMS (a non-surgical brain stimulation) can reduce how much alcohol you drink. It targets people with alcohol use disorder who are not fully stopping, and who want to cut down after a past relapse or failed withdrawal attempt.
DijonAges 18 years+ - NCT04774705Recruiting
Noninvasive vagus nerve stimulation for sepsis in the ICU
This study tests whether a noninvasive device that stimulates the vagus nerve can help adults with sepsis in the intensive care unit. Researchers want to see if adding this treatment improves outcomes compared with standard ICU care.
GarchesAges 18 years+ - NCT04783155Recruiting
Breathing training after lung transplant at Mayo Clinic
This trial studies whether inspiratory muscle training (exercises to strengthen the breathing muscles) improves recovery and other health outcomes after a single- or double-lung transplant. It may help see if adding breathing exercises makes day-to-day function better and supports clinical recovery.
Jacksonville, FloridaAges 18 years+ - NCT04790305RecruitingPhase 4
Huaier granules with standard therapy for early triple-negative breast cancer
This trial looks at whether adding Huaier granules to usual after-surgery treatment can improve outcomes for people with high-risk early-stage triple-negative breast cancer. It focuses on whether the added supplement is safe and helpful after standard care.
Hefei, AnhuiAges 18–70 - NCT04798820Recruiting
Diet coaching after stomach surgery for early stomach cancer
This trial studies whether intensive dietary education (diet coaching) after gastrectomy can improve patients’ nutrition and recovery. It is for people with early-stage primary stomach cancer who have no spread to distant organs.
SeoulAges 20–75 - NCT04799002RecruitingPhase 3
Topotecan and melphalan for eye-sparing retinoblastoma treatment
This trial studies whether a combination chemotherapy treatment (topotecan plus melphalan) can help children with retinoblastoma while keeping the eye when possible. It’s a Phase 3 study, meaning it’s testing effectiveness in a larger group of patients.
Guangzhou, GuangdongAges Any age - NCT04800484Recruiting
Test how different AFO heel height and stiffness affect walking
This study looks at how changing the heel height and stiffness of an AFO (a brace you wear on your lower leg/foot) changes your walking pattern. The goal is to learn which brace settings may improve comfort and walking.
Iowa City, IowaAges 18–70 - NCT04805502Recruiting
Pregnancy exercise program to help prevent childhood obesity
This trial studies whether a structured exercise program during pregnancy can help lower the risk of childhood obesity. If you qualify, you may be asked to exercise during early pregnancy and share information with the research team.
Greenville, North CarolinaAges 18–45 - NCT04810858Recruiting
Study how chronic marijuana affects brain inflammation in HIV
This study looks at whether ongoing marijuana use changes “brain inflammation” and brain cell injury in people living with HIV. It may help researchers understand potential risks or protective effects and how treatment and brain health interact.
Winston-Salem, North CarolinaAges 25–59 - NCT04811794Recruiting
Study of young cancer survivors followed at a Swiss hospital
This study looks at the experiences and health of people who finished childhood cancer treatment and are (or were) followed by Kantonsspital Aarau. It mainly involves sharing and reviewing medical information to understand survivorship after cancer.
AarauAges Any age - NCT04812314Recruiting
Study how exercise changes body fat and metabolism
This study looks at how starting exercise changes the structure and function of body fat. It may help you understand how exercise affects things like cholesterol and blood sugar, even if you’re not currently exercising regularly.
Ann Arbor, MichiganAges 18–40 - NCT04816994RecruitingPhase 3
Cannabis extract for nerve back pain and painkiller needs
This trial studies whether a cannabis extract can reduce acute nerve-related pain in the back and lessen how much pain medication you need. It may help people with a short-term episode of “shooting” nerve pain from the spine.
JerusalemAges 18–70 - NCT04821843RecruitingPhase 3
Study before-surgery treatments for esophageal cancer
This Phase 3 trial compares different “treatments before surgery” for people with esophageal (or esophagus-to-stomach) cancer. It aims to see which approach works better to control the cancer and improve outcomes after surgery.
BeijingAges 18 years+ - NCT04821778RecruitingPhase 3
Testing chemoradiotherapy for esophageal and stomach junction cancer
This Phase 3 study tests a cancer treatment plan that combines chemotherapy and radiation for people with esophageal or esophagus-stomach junction cancer. It aims to see whether this approach works better than standard care for cancers at stages I to IVA.
Anyang, HenanAges 18 years+ - NCT04824144RecruitingPhase 1/Phase 2
Dexmedetomidine for agitation in palliative care delirium
This trial tests whether dexmedetomidine can help calm agitation caused by delirium in adults receiving palliative (comfort-focused) care. It may help reduce restlessness and distress when standard approaches may not be enough.
Calgary, AlbertaAges 18 years+ - NCT04825522RecruitingPhase 4
Vancomycin powder during spine surgery to prevent infection
This trial studies whether placing antibiotic powder (vancomycin) directly in the surgical wound during spine surgery can lower the chance of infection. It may help patients by reducing wound infections after surgery, but it also depends on your surgery details and follow-up timeline.
Windsor, OntarioAges 18 years+ - NCT04831346Recruiting
Laser treatment to improve jaw opening in young women
This study tests whether low-level laser therapy can improve how far you can open your jaw and changes in jaw muscle activity in people with one-sided jaw muscle temporomandibular disorder (TMD). It may help reduce jaw movement limits related to that condition.
GizaAges 18–30 - NCT04838249Recruiting
Hormone therapy study on eating, energy, and heart health
This study looks at how cross-sex hormone therapy affects appetite (eating behavior), metabolism (how your body uses food), energy balance, and cardiovascular (heart and blood vessel) health. You may be included if you meet specific health and safety requirements and can follow study procedures.
Leipzig, SaxonyAges 18 years+ - NCT04844528RecruitingPhase 2
Nicotinamide for CLL patients with recent skin cancer history
This Phase 2 trial tests whether nicotinamide (a form of vitamin B3) can help people with chronic lymphocytic leukemia (CLL) who have had non-melanoma skin cancers in the past 5 years. The study looks at how well new skin cancers can be prevented or reduced.
Salt Lake City, UtahAges 18 years+ - NCT04848896Recruiting
Safety and outcomes study of a smart knee replacement
This trial studies whether a “smart” knee replacement system (CORI) is safe and works well for people getting a total knee arthroplasty (TKA). If you’re a good candidate for a cemented standard knee replacement, the study follows you for two years to check results after surgery.
EppingAges 18 years+ - NCT04854213Recruiting
Study checks radiation effects in colon cancer lung-limited spread
This trial studies how targeted radiation (SBRT) affects cancer biology and immune cells in people with colon cancer that has spread only to a small number of lung nodules. Your tumor tissue will be analyzed to see what changes after treatment.
Naples, NAPOLIAges 18–80 - NCT04855825Recruiting
Wearable robotic exoskeleton to improve walking and thinking in MS
This study tests a wearable robotic exoskeleton to help people with multiple sclerosis walk better and improve thinking/problem-solving. You would use the device during supervised sessions and take brief thinking and movement checks to see if it’s safe and helpful for you.
West Orange, New JerseyAges 18–75 - NCT04861051RecruitingPhase 1
Study ketamine effects on brain sensations in adults
This Phase 1 study tests how ketamine changes “dissociative” experiences—feelings of being disconnected from thoughts or surroundings—in adults. You may be helping researchers better understand ketamine’s effects, which could guide safer future uses.
Palo Alto, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,871 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.