Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,871 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04957329RecruitingPhase 4
Latanoprost eye drops: with or without preservative
This study compares two versions of latanoprost eye drops—one that contains a preservative and one that is preservative-free. It aims to see how each version affects the eye’s “goblet cells,” which help keep the eye surface healthy.
Glostrup Municipality, DanmarkAges 18 years+ - NCT04968509RecruitingPhase 3
PCSK9 shots for calcified aortic valve narrowing
This study tests whether adding PCSK9 inhibitor injections (to statin treatment) can slow or improve calcific aortic valve stenosis, a condition where the heart’s aortic valve becomes stiff and narrowed. It’s aimed at adults with mild-to-moderate disease or certain people with severe disease but no symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04970888Recruiting
Exercise program to improve thinking and brain blood flow in heart failure
This trial tests whether doing a combined mental (cognitive) and physical exercise program can improve thinking and how well blood flows to the brain in people with chronic heart failure. It may help by strengthening both brain function and physical capacity while your heart condition stays stable.
Montreal, QuebecAges 50 years+ - NCT04974593RecruitingPhase 3
Test breath testing to guide a lactose-free diet in IBS
This trial studies whether a breath test (hydrogen/methane lactose testing) can predict who with IBS will improve on a lactose-free diet. If you have moderate-to-severe IBS and regularly eat lactose-containing foods, the test result may help tailor your diet approach.
Jette, Brussels CapitalAges 18–75 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT04983823Recruiting
Study aims to improve long-term heart effects after COVID
This trial looks at how persistent heart-related changes after a past COVID infection may be affected by study treatments. It mainly seeks people who are stable enough for follow-up visits and heart imaging, and who are not already on the specific heart medications required.
Melbourne, VictoriaAges 50–85 - NCT04986293Recruiting
CPAP or BiPAP to reduce motion during radiation
This study tests whether using a breathing machine (CPAP or BiPAP) can help keep you still during radiation treatment. This may improve how accurately radiation is delivered for certain cancers treated with curative intent.
Groningen, Provincie GroningenAges 18 years+ - NCT04987957Recruiting
Music therapy to reduce anxiety during COVID-19
This study tests whether listening to music can help lower anxiety levels in people experiencing stress during the COVID-19 pandemic. You may be able to join if you’re a midwife or nurse and can complete online surveys.
BoluAges Any age - NCT04989790Recruiting
Early mobility program for critically ill children in the PICU
This trial tests whether a structured “early mobility” activity plan (“PICU Up!”) helps children who are on a breathing machine recover or feel better while in the pediatric ICU. It aims to see if starting safe movement earlier makes a difference for critically ill kids.
Madera, CaliforniaAges Up to 18 years - NCT04990024Recruiting
Diet trial for people with obesity using semaglutide
This study compares different diets to see how they affect “arterial stiffness” (how hard the blood vessels are) in people with obesity who are starting semaglutide for weight management. It may help find a diet approach that improves heart and blood-vessel health while you use semaglutide.
Beirut, Riad El SolhAges 18–49 - NCT04995198Recruiting
Prostate cancer patient registry for genetics and treatment outcomes
This registry collects information from people with prostate cancer to better understand how genetics and treatments affect survival and outcomes. Your data may help researchers improve future treatment choices.
Baltimore, MarylandAges 18 years+ - NCT04998916Recruiting
Brain stimulation to reduce heavy drinking in alcohol use disorder
This trial tests a type of noninvasive brain stimulation to see if it can reduce drinking and related “wanting” to drink. It may help people with alcohol use disorder who are currently drinking heavily.
Charleston, South CarolinaAges 21–65 - NCT05000528Recruiting
Program teaching for long-term insomnia patients
This trial tests whether a structured patient education program helps people with chronic insomnia sleep better and feel better. You would likely learn sleep-focused strategies and receive support aimed at improving sleep habits.
NîmesAges 18 years+ - NCT05005793RecruitingPhase 4
Alkali treatment to improve kidney graft blood vessel function
This trial tests whether adding an “alkali” treatment (to raise low blood bicarbonate) can improve blood vessel and kidney graft function in people whose kidney transplant is about 1 year old. It may help if you have lower-than-normal bicarbonate levels while on stable transplant and blood pressure medicines.
Aurora, ColoradoAges 18–80 - NCT05011331Recruiting
Custom pillow study for better shoulder-area sleep
This trial tests whether a specially made pillow can help people with rotator cuff problems sleep better without surgery. You would use the pillow and answer questions about your sleep quality.
East Providence, Rhode IslandAges 18 years+ - NCT05016219Recruiting
Light therapy to improve sleep and thinking in early Alzheimer’s
This trial studies rhythmic light therapy to help people with early Alzheimer’s or mild memory problems, especially when sleep is getting worse. If you fit the sleep and vision/medical safety requirements, the study may see whether the therapy improves sleep and thinking-related symptoms.
Menands, New YorkAges 55 years+ - NCT05017363Recruiting
Child goal-setting coaching during rehab therapy
This study tests whether a child-friendly goal-setting approach helps kids do better during physical therapy or occupational therapy. It may help children and families set clearer goals and feel more motivated during rehab.
Edmonton, AlbertaAges 5–12 - NCT05018520RecruitingPhase 3
Two chemotherapy schedules for newly diagnosed low-risk DLBCL
This trial compares two different shortened treatment schedules of R-CHOP to see which one is safer and works better for people with low-risk diffuse large B-cell lymphoma (DLBCL). It aims to reduce risk from treatment while maintaining strong cancer control after an initial response.
Shanghai, Shanghai MunicipalityAges 14–75 - NCT05023434Recruiting
Brain stimulation study for hand strength in brain tumor patients
This study uses brain stimulation during surgery to see how it affects hand strength and hand function. It may help doctors understand which brain areas are important for hand movement in people with certain brain tumors.
Milwaukee, WisconsinAges 18–75 - NCT05030571Recruiting
Plasma adsorption for adults with liver failure in the ICU
This trial studies a treatment called the Double Plasma Molecular Adsorption System (DPMAS) for people with acute-on-chronic liver failure while they are in the ICU. It aims to see whether filtering certain substances from blood can improve outcomes and safety for critically ill patients.
BangkokAges 18 years+ - NCT05033301Recruiting
Nurse Ned Clinic support for prostate cancer survivors
This study tests a nurse-led clinic (“Nurse Ned Clinic”) to see how well it supports men after curative (potentially curative) prostate cancer treatment. It may help you manage follow-up care during survivorship if you are at low risk of cancer coming back.
Toronto, OntarioAges 18 years+ - NCT05038865Recruiting
How jaw alignment affects teens’ quality of life
This study compares how different types of bite/jaw alignment affect adolescents’ daily comfort and oral-health-related quality of life. It’s mainly done by asking teens to complete questionnaires and comparing groups with and without malocclusion.
Malmö, Skåne CountyAges 12–19 - NCT05040204RecruitingPhase 1
Test supplements to change how sugars attach to blood proteins
This early (Phase 1) study tests how adding specific dietary supplements affects “protein glycosylation,” which means how sugar molecules attach to proteins in your blood. It’s meant to see how the supplements change these blood measurements and whether the approach is tolerable in generally healthy adults.
Sacramento, CaliforniaAges 18–45 - NCT05042219Recruiting
How lung disease treatment may affect heart function
This study looks at how common long-term lung conditions and their treatments may change heart function. It uses heart imaging (an MRI) to see what’s happening, which could help doctors better monitor heart risks in people with lung disease.
AachenAges 18–99
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,871 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.