Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,733 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06064864Recruiting
Switching Infliximab from IV to Subcutaneous for Crohn's
This study tests whether switching from an IV infliximab to a subcutaneous (under-the-skin) version is safe and works well for people with moderate to severe Crohn's disease. It's for people who have never used a biologic and need a new treatment option.
SeoulAges 18–100 - NCT06261554Recruiting
Low-dose sesame oral immunotherapy for children
This study tests if a very low daily dose of sesame protein (given as a powder under the tongue) can help children with sesame allergy become less sensitive to sesame. The goal is to reduce the risk of severe allergic reactions from accidental exposure.
Warsaw, Masovian VoivodeshipAges 3–17 - NCT06421298RecruitingPhase 2
Tafolecimab and sintilimab plus chemo for advanced lung cancer
This trial is testing a new combination of treatments, including an immune drug (sintilimab) and a cholesterol-lowering drug (tafolecimab), along with chemotherapy, for people with advanced lung cancer that no longer responds to standard immunotherapy.
Beijing, Beijing MunicipalityAges 18–75 - NCT03626194Recruiting
Tested an endoscopy method to close internal tissue openings
This study checks whether an endoscopy technique that brings tissue together safely closes several types of internal openings (like perforations or surgical leaks/defects). It also looks at whether the closures work well and have acceptable side effects.
Aurora, ColoradoAges 18–89 - NCT03108196Recruiting
Tested neobladder type after bladder cancer surgery
This trial compares two ways surgeons rebuild a new bladder using either sigmoid colon tissue or ileum (small intestine) tissue. It aims to see which option is safer and works better for people having bladder cancer surgery.
Guangzhou, GuangdongAges 18–100 - NCT06389006RecruitingPhase 2
Combination therapy before surgery for HER2-low, hormone-positive breast cancer
This trial tests a combination of two drugs (disitamab vedotin and toripalimab) followed by chemotherapy before surgery for people with a specific type of breast cancer that is hormone receptor-positive and HER2-low. The goal is to see if this treatment can shrink the tumor and improve outcomes.
Shanghai, Fudan University Shanghai Cancer CenterAges 18 years+ - NCT05911217RecruitingPhase 1
CT041 treatment after chemotherapy for resected pancreatic cancer
This Phase 1 study tests whether CT041 is safe and may help prevent pancreatic cancer from coming back after it’s been removed and you’ve completed standard chemotherapy. You may be eligible if your tumor is positive for CLDN18.2 and your recovery and blood tests meet key requirements.
Beijing, Beijing MunicipalityAges 18–79 - NCT06430515Recruiting
Injecting chemo into tumors for advanced solid cancers
This trial tests if injecting chemotherapy directly into tumors can help people with advanced solid cancers that have stopped responding to standard treatments. It aims to see how safe and effective this approach is.
Wuxi, JiangsuAges 18–85 - NCT06431620Recruiting
Thyroid cancer scan with help of a special hormone
This study tests if a man-made hormone (rhTSH) can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has come back or spread. It aims to see if it helps find and treat cancer that doesn't respond well to standard radioactive iodine.
Nanjing, JiangsuAges 18–75 - NCT06081907RecruitingPhase 1/Phase 2
IBI363 for advanced solid tumors
This trial tests a new drug called IBI363 for people with advanced solid tumors, focusing on lung cancer and melanoma. It aims to see if the drug is safe and effective, especially for those whose previous treatments have stopped working.
Changsha, HunanAges 18–75 - NCT06109558RecruitingPhase 1/Phase 2
LMV-12 plus Osimertinib for advanced lung cancer
This trial tests a new drug called LMV-12 combined with osimertinib for people with advanced non-small cell lung cancer that has certain genetic changes (MET amplification or RET fusion) and has stopped responding to standard EGFR inhibitor treatments.
Changsha, HunanAges 18 years+ - NCT07843472RecruitingPhase 3
Petrelintide for weight loss in people with heart disease
This study tests a new medication called petrelintide to help people with overweight or obesity and heart disease lose weight. It may offer a new way to manage weight and improve heart health.
Anniston, AlabamaAges 40 years+ - NCT07843485RecruitingPhase 3
Weight loss medication for adults with type 2 diabetes
This study tests a new medicine called petrelintide to help people with excess weight and type 2 diabetes lose weight and improve blood sugar control. It may be an option if you've struggled with weight loss through diet alone.
Los Angeles, CaliforniaAges 18 years+ - NCT07843498RecruitingPhase 3
Testing a new weight-loss medicine in adults with overweight or obesity
This study tests a new medication called petrelintide to see how well it helps people lose weight and improve their health. It's for adults with overweight or obesity who have struggled to lose weight with diet alone.
Anniston, AlabamaAges 18 years+ - NCT07845071RecruitingPhase 3
Cebranopadol for acute pain after surgery or injury
This study tests an investigational medication called cebranopadol to see if it safely and effectively relieves acute (short-term) pain after surgery or from a muscle or bone injury. It may offer a new option for people who need relief from moderate to severe pain.
Phoenix, ArizonaAges 18–75 - NCT06107400RecruitingEarly Phase 1
RM-004 cell therapy for Hemoglobin H-Constant Spring disease
This early-phase trial tests a new cell therapy called RM-004 for people with Hemoglobin H-Constant Spring disease, a form of alpha thalassemia that requires regular blood transfusions. The goal is to see if the treatment is safe and can reduce or eliminate the need for transfusions.
Nanning, GuangxiAges 12–35 - NCT05655897Recruiting
Clips for leaky mitral valve in high-surgery-risk heart patients
This trial studies whether a device called GeminiOne can safely and effectively repair a leaky mitral valve using a catheter-based “clip” technique. It may help patients who have moderate-to-severe or severe valve leakage but are considered too high-risk for open surgery.
Suzhou, JiangsuAges 18 years+ - NCT06445881RecruitingPhase 2
Herbal medicine for lung cancer before and after surgery
This trial is testing whether adding a traditional Chinese herbal formula (Modified Si Jun Zi Tang) to standard treatment before and after surgery can help people with early-stage non-small cell lung cancer. It aims to see if the herbs improve outcomes and reduce side effects.
Hangzhou, ZhejiangAges 18–75 - NCT06440070Recruiting
Ultrasound-guided needle thread release for carpal tunnel
This trial tests a new, less invasive way to release the tight ligament in the wrist that causes carpal tunnel syndrome. It uses ultrasound to guide a curved needle and thread to cut the ligament, which may lead to less pain and faster recovery.
Guangzhou, GuangdongAges 40–70 - NCT04360694Recruiting
Testing a step-up hemodialysis schedule for new dialysis patients
This trial studies whether starting hemodialysis in a gradual “step-up” way is safe and works well for adults who are newly starting maintenance dialysis for advanced kidney failure. If you qualify, you may be assigned to a specific dialysis start plan and be closely monitored.
BariAges 18 years+ - NCT07835126Enrolling by invitation
A safer way to treat paroxysrial atrial fibrillation
This study tests a new method of catheter ablation for paroxysmal atrial fibrillation, using a special saline solution and higher power for shorter duration to isolate the pulmonary veins. It aims to improve safety and effectiveness while minimizing damage to surrounding tissue.
Ningbo, ZhejiangAges 18 years+ - NCT07836647RecruitingPhase 3
Study of a new drug for post-traumatic stress disorder
This study tests a new medication, TSND-201, to see if it is safe and effective for people living with PTSD. It is for adults who have already tried at least one other treatment and are looking for a new option.
Denver, ColoradoAges 18 years+ - NCT05773729Recruiting
Gene-modified own stem cell treatment for transfusion-dependent thalassemia
This trial tests a one-time treatment that uses your own (autologous) stem cells that have been changed by gene methods, then returned to you to help manage transfusion-dependent beta-thalassemia. It aims to check safety and whether it can reduce the need for frequent blood transfusions or improve blood health.
ShanghaiAges 3–18 - NCT05776173Recruiting
Gene-modified stem cell treatment for transfusion-dependent thalassemia
This trial tests whether giving you your own (autologous) gene-modified blood stem cells can improve transfusion-dependent beta-thalassemia and its safety. It may help people who do not have a fully matched donor and need an alternative approach to care.
ShanghaiAges 6–35
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,733 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.