Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,831 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03793348Recruiting
Micro-coring device to improve moderate to severe facial wrinkles
This study tests a device that removes tiny skin cores (“micro-coring”) to improve moderate to severe wrinkles on the face, especially the cheeks. It mainly checks safety and whether skin texture looks better after treatment.
Sacramento, CaliforniaAges 40–70 - NCT03813407RecruitingPhase 3
Study of a medicine to treat high potassium in children
This trial tests how safe and effective SZC is for children with high potassium levels (hyperkalaemia) over the short term, and possibly long term. It aims to help lower potassium safely and see whether it works well in different pediatric age groups.
Birmingham, AlabamaAges birth–18 years - NCT03817502RecruitingPhase 3
Cariprazine test for teens with schizophrenia
This trial tests whether cariprazine works and is safe for teens aged 13 to 17 with schizophrenia. It may help if your symptoms are still moderate to severe despite current care.
Culver City, CaliforniaAges 13–17 - NCT03862859RecruitingPhase 4
Warfarin safety for people with atrial fibrillation on dialysis
This trial studies whether the blood thinner warfarin is safe and effective for preventing stroke and blood clots in people who have atrial fibrillation and need long-term dialysis. It may help your care team better balance clot prevention against bleeding risk.
Herlev, HerlevAges 18 years+ - NCT03925194RecruitingPhase 2
Test Anakinra injections under the skin for cystic fibrosis
This Phase 2 study tests whether a medicine called anakinra, given as under-the-skin injections, is safe and may improve lung outcomes in adults with cystic fibrosis. You may be able to join if you meet specific breathing and lab criteria and can follow the study schedule.
Heidelberg, Baden-WurttembergAges 12 years+ - NCT03936153RecruitingPhase 2
Oral abexinostat for relapsed lymphoma after two prior treatments
This Phase 2 study tests how well and how safely an oral medicine called abexinostat works for people with diffuse large B-cell lymphoma that has come back or did not respond to the last treatment. It may help by shrinking lymphoma and controlling the disease using a medication taken by mouth.
BeijingAges 18 years+ - NCT03987308Recruiting
Test shot medicine versus insulin pump for new type 2 diabetes
This study compares a continuous “under the skin” diabetes medicine (called beinaglutide) with an insulin pump (CSII) in people who were recently diagnosed with type 2 diabetes. It aims to see which approach works better and is safer for controlling blood sugar.
Beijing, Beijing MunicipalityAges 18–70 - NCT03994471RecruitingPhase 3
Testing a new peritoneal dialysis fluid for kidney failure
This Phase 3 trial studies how well a new peritoneal dialysis solution works and whether it is safe. It’s meant for adults with kidney failure who already do a specific type of at-home dialysis.
AalborgAges 18 years+ - NCT03993262RecruitingPhase 2
Bortezomib for severe autoimmune encephalitis after rituximab
This Phase 2 study tests whether bortezomib can improve outcomes and safety in adults with severe autoimmune encephalitis. It focuses on people whose condition is confirmed by brain-related autoantibodies and who have already received rituximab.
München, BavariaAges 18 years+ - NCT04005469RecruitingPhase 1/Phase 2
Treprostinil to protect kidneys during transplant injury
This early-phase study tests whether treprostinil (Remodulin®) can reduce injury to a transplanted kidney right after surgery. If it works and is safe, it may help improve outcomes for people receiving a deceased-donor kidney transplant.
Providence, Rhode IslandAges 18–75 - NCT06902896RecruitingPhase 1/Phase 2
FAP iCDC therapy for advanced heart failure from dilated cardiomyopathy
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
Hangzhou, ZhejiangAges 18–75 - NCT07703488Recruiting
Dydrogesterone for abnormal uterine bleeding in teens
This trial tests if dydrogesterone, a hormone pill, can safely help teenagers with heavy or irregular periods. If you or your child have had unusual bleeding that isn't caused by pregnancy or other medical issues, this study may provide treatment options.
Guangzhou, GuangongAges 10–19 - NCT06969807RecruitingPhase 2
Stem cells for diabetic kidney disease
This trial tests whether a type of stem cell called mesenchymal stromal cells (Amimestrocel) can help people with diabetic kidney disease. It aims to see if the treatment is safe and can improve kidney function.
Beijing, Beijing MunicipalityAges 18–80 - NCT06954740RecruitingPhase 2
Stem cell treatment for acute kidney injury
This study tests a special type of stem cell treatment called mesenchymal stromal cells (Amimestrocel) for patients with acute kidney injury. The goal is to see if this treatment can help kidneys recover better than standard care.
Beijing, Beijing MunicipalityAges 18–75 - NCT04014413Recruiting
Fecal transplant for gut and immune-related conditions
This trial studies whether fecal microbiota transplantation (FMT)—a medical procedure using stool from a screened donor to restore gut bacteria—can improve safety and outcomes for people with certain bowel, immune, and metabolic conditions. It may help if your symptoms are thought to be related to an unhealthy gut microbiome, though eligibility is broad and depends on specific safety factors.
Hong Kong, ShatinAges Any age - NCT04042857Recruiting
Gel treatment for toenail fungus
This trial tests how well and how safely an antifungal gel works for toenail fungus in adults. You may be able to join if your toenail fungus is confirmed with lab tests and you can follow the study rules during the study.
South Miami, FloridaAges 18 years+ - NCT04043897RecruitingPhase 2
Oral rifaximin for active microscopic colitis flare
This trial tests whether an oral antibiotic called rifaximin can improve symptoms during a microscopic colitis flare. It aims to see if it is safe and effective for people whose colitis was confirmed by colon biopsy.
Evanston, IllinoisAges 18 years+ - NCT04055220Recruiting
Regorafenib to keep bone cancer from coming back
This trial studies whether regorafenib given after first treatment helps patients with bone sarcoma stay in remission longer. It focuses on safety and whether the medicine can prevent the cancer from growing or returning.
BesançonAges 12 years+ - NCT04161053RecruitingPhase 3
Nitazoxanide to prevent repeat liver brain episodes
This Phase 3 trial tests whether nitazoxanide can help stop hepatic encephalopathy (a “liver-to-brain” confusion problem) from coming back. It’s for adults with cirrhosis who have had at least one past episode, aiming to improve safety and prevent recurrence.
TantaAges 20–65 - NCT04165070RecruitingPhase 1/Phase 2
Stage IV lung cancer trial using pembrolizumab with or without chemotherapy
This Phase 1/2 study tests pembrolizumab (an immune-based cancer treatment) either alone or with chemotherapy in people newly diagnosed with stage IV non-small cell lung cancer (NSCLC). It looks at how well the treatments work and whether they are safe, especially in people who haven’t had treatment yet for metastatic disease.
Gilbert, ArizonaAges 18 years+ - NCT04191681RecruitingPhase 4
Testing ARNI in people with implanted LVAD devices
This trial studies whether a heart medicine called ARNI (sacubitril-valsartan) is safe and works well for people who have a durable LVAD and moderate-to-severe heart pumping weakness. It may help improve symptoms and outcomes, while carefully checking side effects in this higher-risk group.
Cleveland, OhioAges 18 years+ - NCT04230616Recruiting
Testing a knee device to ease osteoarthritis pain
This study tests how well and how safely a knee treatment works for adults with painful knee osteoarthritis seen on X-ray. You might join if you need meaningful pain relief and help with daily function, and can complete required scans and study instructions.
Sint-Truiden, LimburgAges 18 years+ - NCT04319848RecruitingPhase 1
Tissue-engineered cornea transplant for specific eye swelling conditions
This Phase 1 trial tests a new, lab-made tissue transplant to improve corneal clarity in people with certain types of corneal endothelium failure (eye swelling) caused by specific conditions. The main goal is to check safety and see if vision and corneal health improve.
SingaporeAges 21–80 - NCT04342910RecruitingPhase 3
Test camrelizumab plus apatinib for advanced stomach cancer
This trial studies whether combining camrelizumab (an immunotherapy) and apatinib (a targeted pill) can control advanced, unresectable stomach or gastroesophageal junction cancer that has grown after first treatment. It also looks at how safe the combination is.
BeijingAges 18 years+
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,831 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.