Clinical trials
Endodontic Treatment clinical trials
Below are recruiting endodontic treatment clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06955429Recruiting
Testing Biodentine XP for tooth fillings and root treatments
This study tests how well Biodentine XP works over time for fixing cavities or treating tooth roots in children and adults. It aims to see if this material is safe and lasts long in both baby teeth and permanent teeth.
KraainemAges 2 years+ - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+ - NCT06574152Recruiting
Light therapy for pain relief after dental root surgery
This trial tests whether a special light treatment, called photobiomodulation, can help reduce pain and speed up healing after a specific type of dental surgery on the root of a tooth. The surgery involves a small cut in the gum, and the light may help the gum recover faster.
Houston, TexasAges 18 years+ - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT07239505Recruiting
Pre-operative medication for tooth pain relief study
This trial tests a medication called Trinase, given before a root canal, to see if it reduces pain after the procedure compared to a placebo. It may help if you have a painful tooth that needs treatment.
Al Fayyum, Faiyum GovernorateAges 18–50 - NCT07141459Recruiting
Laser disinfection for failed root canal treatment
This trial tests if using a special laser (810 nm diode) to disinfect the tooth after a second root canal treatment can reduce pain and inflammation. It aims to help patients whose previous root canal failed and who have a small infection around the tooth root.
CairoAges 20–40 - NCT07192146Recruiting
Patient experiences after dental emergency treatment
This study looks at how patients feel after receiving emergency dental treatment for tooth pain. It aims to understand what factors affect their recovery and satisfaction.
BangkokAges 18 years+ - NCT06312085Recruiting
Root canal study with new filling material
This study tests a new material for filling root canals after cleaning out an infection. It aims to see if the material helps the tooth heal successfully. You may qualify if you have an infected tooth that has never had a root canal before.
IstanbulAges 18–75 - NCT04528979Recruiting
Tests a bioceramic filling material for root-canal treatment outcomes
This study looks at how well a bioceramic sealing material works for tooth root-canal treatment, including cases where previous treatment did not work. If you have certain types of tooth nerve inflammation or infection, you may be eligible to help compare outcomes and improve care.
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT07343804Recruiting
Dental root canal and heart disease risk study
This trial tests whether treating a tooth infection with a root canal can lower blood markers linked to heart risk in people with stable heart disease.
Rohtak, HaryanaAges 30 years+ - NCT06562816RecruitingPhase 4
Comparing two pain relievers after root canal treatment
This study tests two different pain medicines (trypsin-chymotrypsin and naproxen sodium) to see which one works better for pain after a root canal. It may help you if you need a root canal and are generally healthy.
Karachi, SindhAges 18–45 - NCT07642596Recruiting
Root Canal Treatment Methods and Post-Procedure Pain
This study compares two different techniques for cleaning and shaping root canals (the nerve chambers inside teeth) to see which one causes less pain after treatment. If you have a dead nerve in a back lower tooth, this trial may help us understand the best way to treat it with minimal discomfort.
Eskişehir, OdunpazarıAges 18–65 - NCT06655454RecruitingPhase 2
Numbing medicine after root canal for pain relief
This study tests whether a long-acting numbing medication (bupivacaine) given after a root canal can reduce pain better than a standard short-acting numbing medicine. It is for people who need a root canal for a tooth that is causing sharp, constant pain.
New York, New YorkAges 18 years+ - NCT07019298Recruiting
Comparing dental filling methods for root canals
This trial studies different ways to fill a root canal after treatment to see which works best. It may help if you have a tooth with an infected or dying nerve.
Madrid, SpainAges 18 years+ - NCT07210359Recruiting
New treatment for immature teeth
This trial tests a regenerative treatment for immature permanent teeth (front teeth with developing roots) in children and teens. The goal is to help the tooth's pulp heal and allow the root to continue growing naturally.
Kafr ash Shaykh, Kafr ElsheikhAges 9–15 - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50 - NCT06959602Enrolling by invitation
Comparing two root canal cleaning methods for infected teeth
This trial compares two ways of cleaning infected root canals during a root canal procedure. The goal is to see which method better removes bacteria and improves healing.
AthensAges 18–80 - NCT06948162Recruiting
Testing dental MRI for routine dental care
This study explores whether a dental-dedicated MRI can be used for routine dental imaging. It may help improve dental care by providing detailed images without radiation.
Minneapolis, MinnesotaAges 18 years+ - NCT06671743RecruitingPhase 3
Medication before root canal to reduce pain
This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.
AjmanAges 20–50 - NCT07064083RecruitingEarly Phase 1
Ketorolac for pain after root canal
This trial tests if putting ketorolac (a nonsteroidal anti-inflammatory drug) inside the tooth during a root canal can reduce pain afterward. It is for people who have a dead nerve and long-standing infection in a single-rooted tooth.
GizaAges 18–50 - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT06934317Enrolling by invitation
Bite force after root canal treatment vs. regenerative therapy
This trial compares how strongly you can bite down on a tooth that has had a root canal or a newer regenerative treatment. It is for people with a dead nerve inside a permanent tooth who are otherwise healthy.
IrbidAges 10–60
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Common questions
- Are there clinical trials for endodontic treatment?
- Yes. Clin2 currently lists 24 recruiting endodontic treatment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a endodontic treatment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a endodontic treatment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.