Clinical trials
Fatigue clinical trials
Below are recruiting fatigue clinical trials, each written for real people, not researchers. We’re tracking 293 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06475339Recruiting
Heat and exercise study for healthy active adults
This study looks at how healthy, active people respond to repeated exercise in hot conditions. It will help researchers understand how your body handles heat and fatigue during demanding physical tasks.
Buffalo, New YorkAges 18–39 - NCT06434571RecruitingPhase 2
Comparing two sleep treatments for people with MS
This trial tests if talking with a sleep coach by video is better than a web-based program for improving sleep, reducing fatigue, and protecting the brain in people with multiple sclerosis (MS). Both treatments focus on changing thoughts and habits around sleep.
Kansas City, KansasAges 18–65 - NCT06395441RecruitingPhase 3
Wisconsin ginseng for cancer-related fatigue
This trial tests whether Wisconsin ginseng can help reduce fatigue in people who have had or are getting treatment for a solid tumor cancer. It aims to improve energy levels and quality of life.
Albert Lea, MinnesotaAges 18 years+ - NCT05094297Recruiting
Study of muscle contraction training for veteran tiredness and pain
This study tests whether a guided exercise approach using focused muscle contractions can improve pain, fatigue, or low energy in U.S. Veterans. If you’re having trouble doing everyday activities, this program may help you feel better and function more easily.
Chicago, IllinoisAges 18 years+ - NCT06336525Enrolling by invitation
Sleep health in rural Appalachia and Mississippi Delta
This study examines how sleep is linked to heart and metabolic health in people living in rural Appalachia and the Mississippi Delta. If you are already part of the RURAL Study, you may be able to join this sleep-focused part of the research.
Boston, MassachusettsAges 25–65 - NCT06321965Recruiting
Study of SMA in Children on SMN-Boosting Therapies
This study is looking for children and teens with spinal muscular atrophy (SMA) who are already on a treatment like Spinraza, Evrysdi, or Zolgensma. The goal is to understand different forms of SMA and how the treatment affects them over time.
Bron, RhoneAges birth–16 years - NCT06308770Recruiting
Online group program for lupus fatigue
This trial tests a new online group program to help people with lupus manage chronic fatigue. Participants are randomly assigned to either the program or standard care, and all complete questionnaires online.
EdinburghAges 18–85 - NCT06292377Recruiting
Understanding Fatigue After First Stroke
This study looks at why people feel very tired after a first-time stroke. It involves questionnaires, thinking and memory tests, and a brain MRI to understand sleep, mood, and fatigue better.
BrusselsAges 18 years+ - NCT06250309Recruiting
Mediterranean diet vs. Western diet for fatigue in AIH
This study tests whether a Mediterranean diet can reduce fatigue in people with autoimmune hepatitis (AIH) compared to a typical Western diet. You will receive frozen meals for a week and track your energy levels.
Indianapolis, IndianaAges 18–80 - NCT06207084Recruiting
Home exercise program for people with physical disabilities
This study tests a home-based exercise program for people with permanent physical disabilities that limit mobility. The goal is to see if coaching and training sessions can help you become more active and improve your health.
Birmingham, AlabamaAges 18–89 - NCT06178952Recruiting
Pulse stimulation therapy for post-COVID syndrome
This trial tests a non-invasive brain stimulation method called Transcranial Pulse Stimulation (TPS) to see if it can help people with lingering post-COVID symptoms like fatigue and brain fog. If you've had COVID-19 and still have symptoms for at least 12 months, this study might be an option for you.
Vienna, State of ViennaAges 20–80 - NCT06134219Recruiting
Course for brain fatigue after Graves' disease
This study tests a course designed to help with brain fatigue (mental tiredness) that can happen after Graves' disease. It is for people whose thyroid levels are stable but who still struggle with fatigue.
GothenburgAges 18–72 - NCT06123988Recruiting
Fasting and exercise for advanced breast cancer
This study looks at whether fasting overnight and/or doing exercise can help improve fatigue and other quality-of-life measures in women with advanced hormone receptor positive breast cancer who are already taking a CDK4/6 inhibitor. Participation may involve following a fasting or exercise plan for a period of time.
Phoenix, ArizonaAges 18 years+ - NCT06047626Recruiting
Living well with lymphoma: a fatigue and nutrition study
This study tests if eating more fruits and vegetables can help reduce persistent fatigue in people with lymphoma. You will receive questionnaires by email to track your fatigue and diet over time.
Ann Arbor, MichiganAges 18 years+ - NCT05367245RecruitingPhase 2
Butyrate supplement for Gulf War illness symptoms
This Phase 2 study tests whether a calcium–magnesium butyrate supplement can reduce symptoms of Gulf War Illness (GWI), especially by targeting gut and immune-related pathways. You may be eligible if you’re a Gulf War–era veteran with moderate-to-severe physical symptoms and no conditions or medicines that could explain them instead.
Long Beach, CaliforniaAges 40–70 - NCT05977179Recruiting
Diet program for long-COVID fatigue and poor diet quality
This study tests whether improving diet quality can reduce fatigue and symptoms in people with long-COVID (post-acute COVID-19 syndrome). It may help if your diet quality is currently low and your fatigue is moderate to severe.
Baltimore, MarylandAges 50–94 - NCT05884073Recruiting
Exercise training for cancer care professionals
This trial is about using low- to moderate-intensity exercise to support people who professionally care for patients with cancer. It aims to see whether building this exercise approach is practical and safe for oncology care teams, starting with care professionals in Halifax.
Halifax, Nova ScotiaAges 18 years+ - NCT05869682RecruitingPhase 2
Bright light therapy for fatigue and depression in prostate cancer
This Phase 2 study tests whether a “bright white light” intervention can reduce cancer-related fatigue and depression in people with advanced prostate cancer receiving hormone-based treatment. If it works, it could improve day-to-day well-being while you’re on standard cancer therapies.
Duarte, CaliforniaAges 60 years+ - NCT05236465Recruiting
3-day course for CFS/ME to help you manage symptoms
This trial tests whether a short, structured 3-day course can help people with CFS/ME (myalgic encephalomyelitis/chronic fatigue syndrome) through education and support for symptom management. It may be most helpful if you can currently step back from work or school and are ready to try changes.
TrondheimAges 18–65 - NCT05684367Recruiting
Exercise program to rebuild stamina and energy after breast cancer
This study tests whether a structured exercise program can help older adults with breast cancer regain stamina and reduce fatigue. It focuses on people who are still dealing with moderate fatigue after finishing certain breast cancer treatments.
Gainesville, FloridaAges 60–105 - NCT05674357Recruiting
Training therapists to help people with cancer distress
This trial trains therapists in evidence-based treatments to reduce distress related to cancer and cancer care. You may be able to join if you’re being treated or followed at MGH Cancer Center and your distress level is high.
Boston, MassachusettsAges 18 years+ - NCT05588700Recruiting
Exercise program to reduce long-term cancer fatigue
This trial studies whether a structured physical activity program can reduce ongoing (long-term) fatigue in men with metastatic testicular cancer. It likely helps by improving fitness and energy during and after first-line chemotherapy.
AngersAges 18 years+ - NCT05519878Recruiting
Light plus job therapy for fatigue in genitourinary cancer
This trial tests whether light therapy and an occupational therapy fatigue program can reduce fatigue in people with certain urinary-system cancers who still have mild fatigue during treatment. It may help you feel more energized and manage day-to-day activity while cancer treatment is ongoing.
Duarte, CaliforniaAges 18 years+ - NCT05417867Recruiting
Tracking gut bacteria changes and nausea during chemo
This study looks at how changes in the gut “microbiome” (your gut bacteria) relate to fatigue and chemotherapy-induced nausea in people with early-stage breast cancer. It may help doctors better understand why nausea and fatigue happen and how to predict or manage them during treatment.
Scottsdale, ArizonaAges 20 years+
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Common questions
- Are there clinical trials for fatigue?
- Yes. Clin2 currently lists 293 recruiting fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.