Clinical trials
Frail clinical trials
Below are recruiting frail clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06870149Recruiting
Dance program to improve mobility in older adults at risk
This study tests whether a structured dance program (called GERAS DANCE) can help older adults who are frail or at risk of losing mobility. You would attend dance sessions at the YMCA twice a week, and researchers will see if it improves your walking and daily function.
Hamilton, OntarioAges 65–100 - NCT07015112Recruiting
Medication check for older adults with multiple conditions
This trial tests a team-based approach to review and improve medication use for older adults (65+) who have three or more chronic conditions and are staying in an intermediate care hospital. The goal is to make sure your medicines are as safe and effective as possible.
Barcelona, BarcelonaAges 65 years+ - NCT07020065RecruitingPhase 2
Reduced chemo plus immunotherapy vs immunotherapy alone for older lung cancer patients
This trial tests whether a reduced dose of chemotherapy plus an immunotherapy drug (Cemiplimab) works better than Cemiplimab alone for older or frail patients with advanced lung cancer whose PD-L1 level is below 50%. It aims to find a gentler but effective treatment option.
Fribourg, Villars-sur-GlâneAges 70 years+ - NCT07074639Recruiting
Brain and body training with video games for frail older adults
This trial tests a fun home-based video game program that combines thinking exercises with physical movements to help older adults who are frail. The goal is to see if this training can improve physical and mental function.
ZurichAges 50 years+ - NCT07107529RecruitingPhase 2
Study of daratumumab with teclistamab or talquetamab for frail patients with newly diagnosed multiple myeloma
This trial tests a combination of drugs—daratumumab plus either teclistamab or talquetamab—for people who have just been diagnosed with multiple myeloma and are considered frail. The goal is to see if this treatment is safe and effective for those who may not be strong enough for standard therapies.
Ascoli PicenoAges 18 years+ - NCT07165236Recruiting
Bladder tumor surgery and memory changes study
This study looks at how bladder tumor surgery might affect thinking and memory. It checks blood markers to see if they are linked to any mental changes after the operation.
Osijek, CroatiaAges 18–80 - NCT07175376Recruiting
Building resilience for older adults starting cancer treatment
This study tests a program designed to help older adults with cancer who are starting a new chemotherapy or immune therapy. The program uses an electronic frailty score to provide extra support and resources to improve your overall well-being during treatment.
Charlotte, North CarolinaAges 65 years+ - NCT07257523RecruitingPhase 2
Carbon ion radiation for frail patients with pancreatic cancer
This trial tests a precise type of radiation called carbon ion radiotherapy for people with pancreatic cancer who are too frail for surgery or standard chemotherapy. It aims to see if this treatment can help control the cancer with fewer side effects.
SeoulAges 20 years+ - NCT07258043Recruiting
Lower-dose chemotherapy for frail adults with leukemia
This trial tests whether a personalized, lower-dose chemotherapy plan can help adults with acute lymphoblastic leukemia (ALL) who are frail or have other health problems. It aims to improve survival by adjusting the dose to what each person can handle.
Mexico City, Mexico CityAges 18 years+ - NCT07259499Recruiting
Predictors of emergency visits in frail older adults
This study looks at why frail older adults go to the emergency room. Researchers want to see if blood tests and brain scans can help predict who needs emergency care. Participation involves one interview and having had a recent brain scan and blood work.
Pisa, PisaAges 65 years+ - NCT07303166Recruiting
Osteoporosis care decisions for frail elderly patients
This study learns from doctors in Alsace who treat osteoporosis in frail older patients. It aims to understand what helps or hinders their use of a practical guide. If you are a doctor who has used this guide, your insights could improve future care.
StrasbourgAges 18 years+ - NCT07392515Recruiting
Digital rehab for hip fracture recovery in older adults
This trial tests whether a digital rehabilitation program can help older adults recover their thinking and movement skills after hip fracture surgery. It uses sensors and digital tools to guide therapy, making it easier to do from a rehabilitation ward.
Messina, ItalyAges 65–89 - NCT07433153Recruiting
Phone vs. class for fall prevention in older adults
This trial compares two ways to do fall-prevention exercises: using a smartphone app or joining a community class. It may help older adults who are at risk of falling improve their balance and strength.
Binghamton, New YorkAges 55 years+ - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07442773Recruiting
Support for partners and family caregivers of frail RA patients
This trial tests a support program for people who care for a loved one with rheumatoid arthritis. The program aims to reduce the burden on caregivers and help them feel more supported.
Glostrup Municipality, Capital RegionAges 18 years+ - NCT07454616Recruiting
Supplement and exercise study for pre-frail adults
This study tests whether a special nutrient supplement combined with a simple exercise routine can improve health markers linked to living longer. It is designed for adults who are starting to feel less strong or energetic but are not yet frail.
SingaporeAges 50–80 - NCT07463352Recruiting
Pre-surgery nutrition for frail seniors with hip fractures
This study tests if giving a special protein drink before surgery helps frail older adults with a broken hip recover better. It might reduce complications after surgery.
DüzceAges 65 years+ - NCT07492745Recruiting
Staying active during your hospital stay
This trial tests whether a simple reminder can encourage you to stay active while you are in the hospital. It aims to help older patients maintain their strength and independence during recovery.
BrusselsAges 50 years+ - NCT07497334Recruiting
Combined therapy for older adults with mild thinking and mobility issues
This study tests a program that combines mental exercises, physical training, and brain stimulation to help older adults with mild thinking and mobility problems stay independent. It aims to improve walking, memory, and daily function.
Hong KongAges 60–90 - NCT07513701Recruiting
Building Strength and Balance in Older Adults
This study tests whether a home-based exercise program can help older adults who are experiencing physical weakness improve their strength, balance, and overall resilience. You'll do exercises online at home over several months to see if this approach helps you stay independent and active.
Hong Kong, Hong KongAges 60–90 - NCT07597850RecruitingPhase 2
TCM formula versus HMB supplement for muscle strength in older adults
This study compares a traditional Chinese medicine formula with HMB (a muscle-building supplement) to see which helps preserve muscle strength and bone health in adults aged 65 and older who are starting to show signs of frailty. Both treatments aim to help you stay stronger and more active as you age.
TaipeiAges 65 years+ - NCT07176455Enrolling by invitation
Dietary habits after stomach cancer surgery
This trial studies how older stomach cancer survivors' eating habits change after surgery and tests ways to help them eat healthier. It focuses on people who just had their stomach cancer removed.
NanjingAges 60 years+ - NCT03675724Enrolling by invitationPhase 2
Fisetin for frailty and inflammation in older adults
This trial studies whether fisetin, a supplement-like drug, can reduce frailty and inflammation in people age 70 and older. It may help improve health measures related to aging, but you must meet several safety and medication rules to join.
Rochester, MinnesotaAges 70 years+
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Common questions
- Are there clinical trials for frail?
- Yes. Clin2 currently lists 95 recruiting frail studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frail trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frail trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.