Clinical trials
Frail clinical trials
Below are recruiting frail clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05808686RecruitingPhase 2
Exercise-based training for circulation in older, frail adults
This study tests a special exercise training approach to help small blood vessels work better and improve resilience in frail older adults. If you join, you’ll do training that may involve temporary blood-flow restriction, so safety rules are important.
Wauwatosa, WisconsinAges 65–85 - NCT05830942Recruiting
Training walks plus brain stimulation for thinking skills in older adults
This study tests whether a structured walking exercise, combined with brain stimulation and brain scans, can improve or slow decline in thinking skills. It’s aimed at older adults who notice memory or confusion getting worse.
Gainesville, FloridaAges 65 years+ - NCT05935618Recruiting
Occupational therapy rehab for frail older adults with swallowing trouble
This trial tests an occupational therapy–based rehabilitation program to help frail older adults with swallowing problems work more safely and comfortably. You may be considered if your swallowing screen results fall in a specific range and you can participate in the therapy and consent process.
HvidovreAges 65 years+ - NCT05952024RecruitingPhase 2
Acalabrutinib plus rituximab for older untreated DLBCL
This trial studies the combination of acalabrutinib and rituximab in older or frail people with newly diagnosed DLBCL (a type of lymphoma). It aims to see how well this treatment works and how safe it is for people who may not be able to tolerate standard chemotherapy.
Berkeley, CaliforniaAges 65–99 - NCT05963113Recruiting
Exercise and extra protein for swallowing and aging strength
This study tests whether a swallowing exercise program plus a higher-protein intake can improve function in older adults at risk for swallowing problems. It may help by strengthening muscles used for swallowing and supporting overall physical health.
New York, New YorkAges 65 years+ - NCT05993754Recruiting
Preventing confusion after surgery in frail older adults
This study tests whether a special nursing care plan can help prevent confusion after surgery in older adults who are frail. If you are 65 or older, having planned surgery, and generally healthy enough, this trial may be an option.
Santiago, Santiago MetropolitanAges 65 years+ - NCT06040801Recruiting
Geriatric care for older adults with advanced stomach, bile duct, or pancreatic cancer
This study tests a special geriatric (older-adult) care program for people over 65 with advanced stomach, bile duct, or pancreatic cancer who are receiving palliative chemotherapy. The goal is to see if extra support from a geriatric team can help improve quality of life and treatment outcomes.
Taoyuan, TaiwanAges 65 years+ - NCT06190288Recruiting
Transitional care for frail older adults leaving the hospital
This study tests a program where a team of healthcare workers helps frail older adults transition from the hospital back home. It aims to prevent health problems and support you in managing your health after discharge.
BaselAges 65 years+ - NCT06202118Recruiting
Alpha radiation therapy for breast cancer in older or frail patients
This trial tests a new type of radiation therapy (DaRT) that uses tiny, implantable seeds to deliver targeted alpha radiation to breast tumors. It is designed for older patients (65+) or those who are too frail for surgery, offering a less invasive option for controlling the cancer.
JerusalemAges 65–120 - NCT06208527RecruitingPhase 2
Nicotinamide Riboside for Frailty in Older Adults
This trial tests whether a daily supplement called nicotinamide riboside can help older adults who feel weak or frail to get stronger and more energetic. It lasts for several months and involves simple tests like a walking test and memory checks.
Bergen, VestlandAges 75 years+ - NCT06441136Recruiting
Study on age-related voice changes and social life
This trial studies how age-related voice changes (presbyphonia) affect social interactions and daily life. You may be eligible if you have thinning of the vocal cords and can complete voice assessments and questionnaires.
Iowa City, IowaAges 65 years+ - NCT06444321Recruiting
Integrated care for frail patients with heart failure
This trial tests a special care program for people with both frailty (being weak or vulnerable) and heart failure (when the heart doesn't pump well). The program brings together different types of support to help you manage your health better after a hospital stay.
Drammen, AkershusAges 18 years+ - NCT06469437Recruiting
Geriatric check for older adults with type 2 diabetes
This study looks at how a full health check for older adults with type 2 diabetes can help doctors choose the best treatment plan. It aims to improve care for people 60 and older.
Porto Alegre, Rio Grande do SulAges 60 years+ - NCT05441163Recruiting
Nutrition and exercise program for frail advanced digestive cancer patients
This study tests whether a personalized plan for food (nutrition) and safe, adapted exercise can improve care in frail people with advanced digestive cancers. You may be more likely to feel stronger and better supported during first-line cancer treatment.
Tours, Institut CurieAges 18 years+ - NCT06517017RecruitingPhase 2
Gentle combination therapy for frail myeloma patients
This study tests a combination of three drugs (isatuximab, dexamethasone, and lenalidomide) given at a slow, gentle pace for people with multiple myeloma who are considered very frail. The goal is to see if this gentler approach works well and is safe for those who may not tolerate stronger treatments.
Salt Lake City, UtahAges 18 years+ - NCT06530511RecruitingPhase 2
PRO trial for elderly, frail patients with a type of lymphoma
This trial tests a combination of three drugs (Polatuzumab, Rituximab, and Orelabrutinib) for elderly patients who are frail or over 80 with a specific type of untreated diffuse large B-cell lymphoma (non-GCB DLBCL). The goal is to see if this drug combo is safe and effective for those who may not tolerate standard chemotherapy.
Nantong, JiangsuAges 60 years+ - NCT06547593Recruiting
Nutrition study for frailty in older adults
This study tests a special nutrition program to help older adults who are frail become stronger and healthier. If you are between 65 and 85 and have signs of frailty, this program might help you feel better and be more active.
Beijing, Beijing MunicipalityAges 65–85 - NCT06552234RecruitingPhase 2
Study of repotrectinib for older or frail patients with ROS1-positive lung cancer
This trial tests an oral targeted therapy called repotrectinib in people with advanced non-small cell lung cancer (NSCLC) that has a change in the ROS1 gene. It is designed for patients who are either 70 or older, or have a lower performance status (ECOG 2 or higher), meaning they may be more frail or have more symptoms. The goal is to see if repotrectinib can help shrink or control the cancer.
Aix-en-Provence, Bouches Du RhôneAges 18 years+ - NCT06671353Recruiting
Video decision support for advance care planning in frail older adults
This trial tests if watching a video helps older adults with frailty make informed decisions about future medical care. You may be able to join if you are 65 or older, have been diagnosed with frailty, and can watch a video and sign a consent form.
TaipeiAges 65 years+ - NCT06732193Recruiting
Fissios App for recovery after lung cancer surgery
This trial tests whether using a smartphone app (Fissios) after lung cancer surgery helps you recover with fewer complications. If you are scheduled for lung surgery for non-small cell lung cancer and have a smartphone, you may be eligible.
Madrid, MadridAges 18 years+ - NCT06775028Recruiting
Integrated care for older adults with atrial fibrillation
This trial is testing a new approach to care for older adults with atrial fibrillation (an irregular heartbeat) who also have other health conditions. It aims to see if a more integrated, team-based care plan helps improve their overall health and quality of life.
HaskovoAges 65 years+ - NCT06785740Recruiting
Statins for older stroke patients with frailty
This study looks at how well statins work in older stroke or TIA patients who are already taking them and also have some frailty. The goal is to understand if continuing statins is safe and helpful for this group.
Almere StadAges 70–120 - NCT06836167Recruiting
Integrated care for frail older adults
This study tests a program called +AGIL Barcelona that provides integrated care for older adults living at home who show signs of frailty. It aims to help them stay independent and healthy.
BarcelonaAges 65 years+ - NCT06857981Recruiting
Prepare for Your Surgery: A Program for Frail Patients
This trial is for people who are frail and planning to have elective surgery in at least 4 weeks. It focuses on a program to help you prepare for your surgery, so you may have a better recovery.
Santiago, Santiago MetropolitanAges 18 years+
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Common questions
- Are there clinical trials for frail?
- Yes. Clin2 currently lists 95 recruiting frail studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frail trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frail trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.