Clinical trials
Frail clinical trials
Below are recruiting frail clinical trials, each written for real people, not researchers. We’re tracking 90 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07321808Recruiting
Shingles vaccine study for frail patients
This study tests how well the shingles vaccine works in people with weakened immune systems due to conditions like rheumatoid arthritis, cancer, or multiple sclerosis. It aims to see if the vaccine is safe and effective for these patients.
Pavia, PaviaAges Any age - NCT05935618Recruiting
Occupational therapy rehab for frail older adults with swallowing trouble
This trial tests an occupational therapy–based rehabilitation program to help frail older adults with swallowing problems work more safely and comfortably. You may be considered if your swallowing screen results fall in a specific range and you can participate in the therapy and consent process.
HvidovreAges 65 years+ - NCT07303166Recruiting
Osteoporosis care decisions for frail elderly patients
This study learns from doctors in Alsace who treat osteoporosis in frail older patients. It aims to understand what helps or hinders their use of a practical guide. If you are a doctor who has used this guide, your insights could improve future care.
StrasbourgAges 18 years+ - NCT07275216RecruitingPhase 2
A study of pembrolizumab plus chemo for frail Hodgkin lymphoma patients
This trial tests a combination of the immunotherapy drug pembrolizumab with chemotherapy for people with newly diagnosed Hodgkin lymphoma who are too frail for standard treatment. The goal is to find a safer, effective option for patients who are older or have other health issues.
Duarte, CaliforniaAges 18 years+ - NCT07259499Recruiting
Predictors of emergency visits in frail older adults
This study looks at why frail older adults go to the emergency room. Researchers want to see if blood tests and brain scans can help predict who needs emergency care. Participation involves one interview and having had a recent brain scan and blood work.
Pisa, PisaAges 65 years+ - NCT07258043Recruiting
Lower-dose chemotherapy for frail adults with leukemia
This trial tests whether a personalized, lower-dose chemotherapy plan can help adults with acute lymphoblastic leukemia (ALL) who are frail or have other health problems. It aims to improve survival by adjusting the dose to what each person can handle.
Mexico City, Mexico CityAges 18 years+ - NCT07257523RecruitingPhase 2
Carbon ion radiation for frail patients with pancreatic cancer
This trial tests a precise type of radiation called carbon ion radiotherapy for people with pancreatic cancer who are too frail for surgery or standard chemotherapy. It aims to see if this treatment can help control the cancer with fewer side effects.
SeoulAges 20 years+ - NCT07254403Recruiting
Beef vs. plant protein for muscle health in older adults
This study compares how well beef protein and plant protein help build muscle in older adults who may be starting to feel weak or lose muscle. You'll eat test meals and have your muscle response measured using a safe, stable isotope technique.
College Station, TexasAges 65–95 - NCT05710809Recruiting
Exercise and health check study for older colorectal cancer patients
This trial looks at sarcopenia (loss of muscle strength/size) and vertigo (feeling dizzy or off-balance) in older adults with colorectal cancer. It tests whether a structured, exercise-based approach can help these issues alongside cancer care.
CopenhagenAges 65 years+ - NCT04012840Recruiting
Prevention program study for frailty risk in older adults
This study looks at what makes older adults become frail and checks whether a prevention-focused geriatric assessment and regular follow-up can help. If you’re at risk for frailty, you may be asked to join assessments and answer follow-up calls for three years.
Paris, Île-de-France RegionAges 70 years+ - NCT07175376Recruiting
Building resilience for older adults starting cancer treatment
This study tests a program designed to help older adults with cancer who are starting a new chemotherapy or immune therapy. The program uses an electronic frailty score to provide extra support and resources to improve your overall well-being during treatment.
Charlotte, North CarolinaAges 65 years+ - NCT07176455Enrolling by invitation
Dietary habits after stomach cancer surgery
This trial studies how older stomach cancer survivors' eating habits change after surgery and tests ways to help them eat healthier. It focuses on people who just had their stomach cancer removed.
NanjingAges 60 years+ - NCT07165236Recruiting
Bladder tumor surgery and memory changes study
This study looks at how bladder tumor surgery might affect thinking and memory. It checks blood markers to see if they are linked to any mental changes after the operation.
Osijek, CroatiaAges 18–80 - NCT07107529RecruitingPhase 2
Study of daratumumab with teclistamab or talquetamab for frail patients with newly diagnosed multiple myeloma
This trial tests a combination of drugs—daratumumab plus either teclistamab or talquetamab—for people who have just been diagnosed with multiple myeloma and are considered frail. The goal is to see if this treatment is safe and effective for those who may not be strong enough for standard therapies.
Ascoli PicenoAges 18 years+ - NCT07086716Recruiting
Frailty study for hip or knee replacement patients
This study looks at frailty in people who have had a planned hip or knee replacement. It aims to understand how frailty affects recovery.
Rovato, BSAges 18 years+ - NCT07074639Recruiting
Brain and body training with video games for frail older adults
This trial tests a fun home-based video game program that combines thinking exercises with physical movements to help older adults who are frail. The goal is to see if this training can improve physical and mental function.
ZurichAges 50 years+ - NCT07015112Recruiting
Medication check for older adults with multiple conditions
This trial tests a team-based approach to review and improve medication use for older adults (65+) who have three or more chronic conditions and are staying in an intermediate care hospital. The goal is to make sure your medicines are as safe and effective as possible.
Barcelona, BarcelonaAges 65 years+ - NCT07020065RecruitingPhase 2
Reduced chemo plus immunotherapy vs immunotherapy alone for older lung cancer patients
This trial tests whether a reduced dose of chemotherapy plus an immunotherapy drug (Cemiplimab) works better than Cemiplimab alone for older or frail patients with advanced lung cancer whose PD-L1 level is below 50%. It aims to find a gentler but effective treatment option.
Fribourg, Villars-sur-GlâneAges 70 years+ - NCT05993754Recruiting
Preventing confusion after surgery in frail older adults
This study tests whether a special nursing care plan can help prevent confusion after surgery in older adults who are frail. If you are 65 or older, having planned surgery, and generally healthy enough, this trial may be an option.
Santiago, Santiago MetropolitanAges 65 years+ - NCT06857981Recruiting
Prepare for Your Surgery: A Program for Frail Patients
This trial is for people who are frail and planning to have elective surgery in at least 4 weeks. It focuses on a program to help you prepare for your surgery, so you may have a better recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT06870149Recruiting
Dance program to improve mobility in older adults at risk
This study tests whether a structured dance program (called GERAS DANCE) can help older adults who are frail or at risk of losing mobility. You would attend dance sessions at the YMCA twice a week, and researchers will see if it improves your walking and daily function.
Hamilton, OntarioAges 65–100 - NCT06874413Enrolling by invitation
Exercise program for frail older adults before hernia surgery
This study tests whether a supervised exercise program before hernia repair surgery helps frail older adults recover better. The program includes physical exercises and breathing muscle training.
Greenville, South CarolinaAges 65 years+ - NCT06835530RecruitingPhase 2
Rituximab and CC-99282 for older frail patients with large b-cell lymphoma
This trial tests a combination of two drugs, rituximab and CC-99282, as a first treatment for older adults with diffuse large b-cell lymphoma who are too frail for standard chemotherapy. The goal is to see if this gentler approach can effectively control the disease while being easier to tolerate.
Alessandria, AlessandriaAges 80 years+ - NCT06441136Recruiting
Study on age-related voice changes and social life
This trial studies how age-related voice changes (presbyphonia) affect social interactions and daily life. You may be eligible if you have thinning of the vocal cords and can complete voice assessments and questionnaires.
Iowa City, IowaAges 65 years+
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Common questions
- Are there clinical trials for frail?
- Yes. Clin2 currently lists 90 recruiting frail studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frail trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frail trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.