Clinical trials
Fuchs' Endothelial Dystrophy clinical trials
Below are recruiting fuchs' endothelial dystrophy clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05275972RecruitingPhase 3
Compare cornea surgery thickness results for FECD
This Phase 3 trial compares outcomes from two cornea transplant procedures in people with FECD, a disease that makes the cornea swell and affect vision. It may help you and others by identifying which approach best supports clear vision and stable corneal thickness after surgery.
Palo Alto, CaliforniaAges 18 years+ - NCT03249337RecruitingPhase 4
Ripasudil drops before Descemet stripping surgery in Fuchs disease
This trial tests whether Glanatec (ripasudil) eye drops help patients with Fuchs endothelial dystrophy get better results from Descemet stripping surgery. It may help improve vision and reduce symptoms for people whose vision problems come mainly from the Fuchs changes in the cornea.
Glenview, IllinoisAges 18–91 - NCT04258787Recruiting
Eye drop treatment for Fuchs corneal swelling
This trial studies a treatment for people with Fuchs’ dystrophy that affects the clear layer at the back of the cornea. It may help improve how clear your vision is after the cornea can no longer pump fluid out properly.
Portland, OregonAges 18 years+ - NCT04319848RecruitingPhase 1
Tissue-engineered cornea transplant for specific eye swelling conditions
This Phase 1 trial tests a new, lab-made tissue transplant to improve corneal clarity in people with certain types of corneal endothelium failure (eye swelling) caused by specific conditions. The main goal is to check safety and see if vision and corneal health improve.
SingaporeAges 21–80 - NCT04440280RecruitingPhase 2
NAC drops to improve cornea disease during cataract surgery
This Phase 2 study tests whether eye drops containing a medicine called N-acetylcysteine (NAC) can reduce damaging “reactive oxygen” in people with advanced Fuchs’ endothelial corneal dystrophy (FECD). It involves people who need a special cornea transplant (DMEK) at the same time as cataract surgery, aiming to improve cornea healing and vision.
Boston, MassachusettsAges 21 years+ - NCT05436665Recruiting
Cornea transplant surgery for damaged corneal lining in adults
This study looks at a specific type of cornea transplant (called endothelial lamellar transplant) for people with Fuchs disease or other causes of corneal swelling that affect vision. It aims to see whether this surgical approach improves outcomes and quality of life after surgery.
Edegem, AntwerpAges 18 years+ - NCT05636579RecruitingPhase 1
Testing safety of multiple EO2002 eye drops for corneal swelling
This Phase 1 study tests whether EO2002 eye drops are safe and well tolerated in people with painful corneal swelling caused by the cornea’s inner lining not working well. It focuses on safety first, but your eye symptoms and vision may be monitored to see how you respond.
Mexico City, Mexico CityAges 18 years+ - NCT06261346Recruiting
Growth factors in corneal transplant surgery
This study tests whether adding a special growth factor solution to the fluid used during corneal transplant surgery helps the transplant heal better. It is for patients undergoing a specific type of corneal transplant called DSEK or DMEK.
Miami, FloridaAges 18–80 - NCT06425666Recruiting
Cataract surgery with triple-DMEK for Fuchs dystrophy
This trial tests a combined surgery that treats both cataract and Fuchs endothelial corneal dystrophy at the same time. It compares the standard cataract surgery to one that also replaces the damaged cornea layer, aiming to improve vision with fewer steps.
Aarhus N, Central JutlandAges 18 years+ - NCT06652321Recruiting
New laser method for corneal transplant in Fuchs' dystrophy
This trial tests a new way to perform a corneal transplant (DSAEK) using a laser to prepare the donor tissue. It may help people with Fuchs' dystrophy or certain types of corneal swelling, but not those with glaucoma, scarring, or other eye diseases.
GizaAges Any age - NCT06881771Recruiting
Tracking Fuchs' dystrophy progression and genetics in the UK
This study follows people with Fuchs' endothelial corneal dystrophy over time to see how the condition changes and how it relates to their genes. It aims to help doctors better predict and manage the disease.
LondonAges 18 years+ - NCT06966167Recruiting
Laser vs. standard cataract surgery in Fuchs' dystrophy
This study compares two types of cataract surgery in people with Fuchs' dystrophy: one using a laser and the standard method. It looks at which approach gives better results for the cornea and vision.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT07024693RecruitingPhase 2
Study of DT-168 for corneal transplant patients with Fuchs dystrophy
This trial tests an investigational eye drop (DT-168) in people with Fuchs endothelial corneal dystrophy who are already scheduled for a corneal transplant. The goal is to see if DT-168 can improve outcomes or delay the need for surgery.
Indianapolis, IndianaAges 30 years+ - NCT07265388Recruiting
Testing a scoring system for Fuchs dystrophy and cataract surgery
This study tests a scoring system to predict how well people with Fuchs dystrophy do after cataract surgery. It may help doctors plan better treatment for your cornea and lens.
Madrid, MadridAges 40 years+ - NCT07325097RecruitingPhase 1
Corneal implant for swelling of the cornea
This trial tests a new corneal implant to treat corneal swelling caused by Fuchs' dystrophy or after cataract surgery. It aims to improve vision and reduce the need for a full corneal transplant.
YerevanAges 18 years+ - NCT07373821Recruiting
Lying face up after cornea transplant surgery
This study tests if lying face up after DMEK surgery (a cornea transplant for Fuchs dystrophy) helps the surgery work better. It may be an option for people with Fuchs dystrophy or bullous keratopathy who can lie flat on their back.
HeidelbergAges Any age - NCT07539012Recruiting
Corneal Membrane Polishing for Fuchs Eye Disease
This trial tests a surgical technique called Descemet membrane polishing during corneal transplant surgery for Fuchs endothelial corneal dystrophy, a condition that clouds the cornea (the clear front part of your eye). The study aims to see if this polishing step improves healing and vision after surgery.
Saint-Etienne, FranceAges 18 years+ - NCT07217249Enrolling by invitation
Donor diabetes and cornea transplant success at 5 years
This study looks at how a donor's diabetes might affect the long-term success of a specific type of cornea transplant called DMEK. Participants from an earlier study (DEKS) will be followed for up to 5 years to see how well the transplant is doing.
Atlanta, GeorgiaAges 30–93 - NCT06969586Enrolling by invitation
Eye drops study for Fuchs corneal disease and glaucoma
This study tests whether special eye drops (Rho-kinase inhibitors) can improve the health of the cornea in people who have both Fuchs endothelial corneal dystrophy and glaucoma. The drops may help reduce corneal swelling and preserve your vision.
ZagrebAges 40–90 - NCT05742321Recruiting
Study how corneal cell genetics relate to Fuchs’ disease
This study looks at how a person’s corneal cell genetic makeup relates to what happens in Fuchs’ corneal endothelial dystrophy. It may help doctors understand the disease better and guide future care, especially if you need a corneal transplant.
Saint-EtienneAges 18 years+ - NCT05716945RecruitingPhase 4
OPTIMISE Study for patients getting cornea transplant surgery
This trial looks at how to manage medicine around DMEK corneal transplant surgery to improve eye outcomes and safety. It may help people having this specific type of cornea transplant by testing an approach in the time after surgery.
Apeldoorn, GelderlandAges 21 years+ - NCT06048380RecruitingPhase 3
Ripasudil drops for FED patients having cataract surgery
This trial tests if ripasudil eye drops can help people with Fuchs' endothelial dystrophy (FED) during and after cataract surgery. It aims to see if the drops protect the eye's inner layer and improve recovery.
Singapore, SingaporeAges 50–100 - NCT02118922Recruiting
Testing a light-scanning eye exam to diagnose corneal thinning
This study tests whether a special “Brillouin” microscope scan can spot corneal ectasia and related cornea conditions. It may help doctors diagnose problems earlier and better sort out who needs closer eye care.
Boston, MassachusettsAges 20–75 - NCT06859411Recruiting
Posterior corneal transplant study
This study looks at how well people do after a specific type of corneal transplant called posterior lamellar keratoplasty. It aims to understand long-term outcomes for patients who had this surgery.
MetzAges 18 years+
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Common questions
- Are there clinical trials for fuchs' endothelial dystrophy?
- Yes. Clin2 currently lists 25 recruiting fuchs' endothelial dystrophy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fuchs' endothelial dystrophy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fuchs' endothelial dystrophy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.