Clinical trials
Gastroesophageal Reflux clinical trials
Below are recruiting gastroesophageal reflux clinical trials, each written for real people, not researchers. We’re tracking 61 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05678491Enrolling by invitation
Endoscopic treatment for reflux after gastric sleeve surgery
This trial studies an endoscopic procedure to treat gastroesophageal reflux disease (GERD) in people who had gastric sleeve surgery. It may help if reflux symptoms are not controlled on once-daily acid medicine (PPI) or if you cannot tolerate it and want an alternative.
TrondheimAges 18–70 - NCT05066594Recruiting
Registry for a procedure to treat long-term reflux
This is an observational study (no experimental treatment) that follows people who choose a specific procedure called transoral incisionless fundoplication (TIF) with the EsophyX device for long-term acid reflux. It aims to track outcomes for up to 5 years at San Raffaele Hospital.
MilanAges 18–80 - NCT03853772Enrolling by invitation
Heartburn registry for long-term symptom and care follow-up
This registry enrolls people with GERD (chronic heartburn/reflux) to track symptoms and treatments over time for up to 5 years. It may help researchers understand what works best in everyday care, and you’ll be asked to complete check-in surveys.
Orange, CaliforniaAges 18 years+ - NCT05216133Enrolling by invitation
Study WTC lung and reflux markers using noninvasive tests
This study looks at blood “biomarkers” and breathing/acid-reflux measurements in FDNY workers exposed to the 9/11 site to understand airway disease, Barrett’s esophagus, and reflux. It may help identify which people have hidden (underdiagnosed) reflux or lung involvement after 9/11.
New York, New YorkAges 37–90 - NCT06641375Recruiting
Heat treatment for chronic acid reflux (AREA study)
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
Hyderabad, TelanganaAges 18–70 - NCT05330910Recruiting
Repair of a stomach valve during sleeve weight-loss surgery
This trial tests whether doing a specific repair near the stomach valve (the gastroesophageal junction) during laparoscopic sleeve gastrectomy can help people with a loose valve. It is aimed at adults who have a particular endoscopy finding (Hill grade III) and choose this weight-loss surgery.
SingaporeAges 21–65 - NCT07482969Recruiting
GERD symptoms in Czech children study
This study asks children ages 8-9 and 12-13 about symptoms of gastroesophageal reflux disease (GERD), a condition where stomach acid flows back into the throat. It aims to understand how common these symptoms are.
PragueAges 8–13 - NCT05870163Recruiting
Registry study of RefluxStop for GERD patients
This registry study follows people with long-term acid reflux (GERD) who get the RefluxStop treatment. It mainly collects real-world safety and performance information to see how well the device helps over time.
FriedrichshafenAges 18 years+ - NCT04065516Enrolling by invitation
Test for reflux treatment after POEM for achalasia
This study looks at a specific treatment (“ARAT”) to help people who develop acid reflux after a procedure called POEM for achalasia. It may help reduce reflux symptoms and abnormal acid levels in the stomach/esophagus after the original procedure.
Mexico City, Mexico CityAges 18 years+ - NCT07814027Recruiting
Trial comparing two surgeries for achalasia
This trial compares two surgeries to treat achalasia, a condition where the esophagus fails to push food into the stomach. Both procedures aim to relax the muscle at the bottom of the esophagus, and the study will see which one works better for improving your symptoms.
Minya, Minya GovernorateAges 18–75 - NCT07809620Recruiting
Acid reflux surgery: Who is likely to feel better?
This study looks at patients who are planning to have surgery for severe acid reflux (called fundoplication). It aims to find out which patients are most likely to see their symptoms improve after the operation, so doctors can better choose who will benefit.
Minya, Minya GovernorateAges 18 years+ - NCT07718828Recruiting
Comparing two types of hernia surgery for hiatal hernia
This study compares two laparoscopic surgery methods (Nissen vs Toupet) for fixing a hiatal hernia. Both aim to stop stomach acid from flowing back into the esophagus and help relieve heartburn or reflux symptoms.
Sofia, Sofia-GradAges 18–90 - NCT07708220Recruiting
Laparoscopic treatment for acid reflux in children
This trial tests a minimally invasive surgery to treat gastroesophageal reflux disease (GERD) in children. It aims to reduce symptoms and improve quality of life for kids who have not had prior reflux surgery.
TantaAges 2–18 - NCT07678177Recruiting
Study of tegoprazan for patients with GERD
This study looks at how well and how safely the drug tegoprazan works for people with gastroesophageal reflux disease (GERD). It may help if you have symptoms like heartburn or acid reflux.
SeoulAges 19 years+ - NCT07667894Recruiting
Online mindfulness for emotional distress in GERD
This study tests an online mindfulness program called MIED to see if it can help reduce emotional distress for people with GERD (chronic acid reflux). It involves weekly online sessions and questionnaires over several weeks.
Beijing, Beijing MunicipalityAges 18–65 - NCT00590239Recruiting
Study for early changes in Barrett’s esophagus
This study focuses on people with Barrett’s esophagus who are coming in for an endoscopy check or for treatment of early surface changes. The goal is to better understand these early warning areas and how to manage them safely.
Kansas City, MissouriAges 18 years+ - NCT07556289RecruitingPhase 2
Minimally invasive reflux surgery for Asian patients with severe heartburn
This trial tests a newer, less invasive surgical procedure called TIF (Transoral Incisional Fundoplication) for patients with severe acid reflux and regurgitation that hasn't improved with high-dose medications. The procedure is done through the mouth rather than the abdomen, and researchers will follow patients for 5 years to see if it works and is safe in Asian populations.
Hong KongAges 18–80 - NCT06031025Recruiting
Study of tummy problems in at-risk infants
This study looks at how common stomach and gut issues are in babies who were born early or had problems at birth, and how these issues change over time.
RomaAges 3 months–2 years - NCT07291700Recruiting
Talcid for acid rebound after stopping long-term PPI therapy
This study tests whether Talcid chewable tablets can relieve the acid reflux symptoms that often happen when you stop taking a long-term daily acid-reducing medicine (like omeprazole). It is for people whose doctor says they no longer need that medicine.
LeverkusenAges 18 years+ - NCT07268820RecruitingPhase 4
Nighttime heartburn treatment for erosive GERD
This trial tests a treatment for nighttime heartburn caused by GERD, a condition where stomach acid damages the esophagus. It is for adults who have had nighttime heartburn for more than 3 months and have been diagnosed with erosive GERD.
AnsanAges 19 years+ - NCT06926374Recruiting
Robotic surgery for gastrointestinal and urologic conditions
This trial tests a new robotic surgery system for common operations on the colon, rectum, prostate, kidney, bladder, stomach, esophagus, gallbladder, and hiatal hernia. It may offer a less invasive option for patients who need surgery for these conditions.
Hong KongAges 18–80 - NCT07148583Recruiting
BioAmicus Complete for tummy troubles in babies
This study tests if a probiotic supplement called BioAmicus Complete can help babies with common digestive issues like colic, reflux, constipation, or loose stools. It might be a good option if your baby has these symptoms and you haven't used other probiotics or antibiotics recently.
Haiphong, Hai PhongAges birth–2 years - NCT07121803Recruiting
Special ice cream for esophagus health in diabetes
This study tests whether a special ice cream can help the esophagus (the tube that carries food to your stomach) work better in people with type 2 diabetes. Researchers want to see if the ice cream can improve how food moves down the esophagus.
MoscowAges 18–80 - NCT07063576RecruitingPhase 2/Phase 3
Baclofen for persistent heartburn or regurgitation
This trial tests whether the drug baclofen can help patients who still have acid reflux symptoms (heartburn or regurgitation) despite taking standard treatments like PPIs for 8 weeks. If you've tried PPIs and still have symptoms, this may be an option.
DhakaAges 18 years+
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Common questions
- Are there clinical trials for gastroesophageal reflux?
- Yes. Clin2 currently lists 61 recruiting gastroesophageal reflux studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastroesophageal reflux trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastroesophageal reflux trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.