Clinical trials
Gastroesophageal Reflux clinical trials
Below are recruiting gastroesophageal reflux clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06984484Recruiting
Afluxin for GERD: safety and performance study
This trial tests a new treatment called Afluxin for people with gastroesophageal reflux disease (GERD), which causes heartburn and regurgitation. It aims to see if Afluxin is safe and works better than a placebo (inactive control) to relieve symptoms.
GenovaAges 18–75 - NCT06339801Recruiting
Mucosal impedance test for GERD diagnosis
This study tests a new way to measure how your esophagus lining reacts to acid (called mucosal impedance) to help diagnose GERD. It's for people who still have symptoms even after taking standard medication for 8 weeks.
Buenos AiresAges 18–65 - NCT06564246RecruitingPhase 4
Comparing Vonoprazan vs. Pantoprazole for GERD
This trial tests a newer medication called vonoprazan against the standard treatment pantoprazole for patients with gastroesophageal reflux disease (GERD). The goal is to see which one works better for controlling symptoms like heartburn and acid reflux over 8 weeks.
GizaAges 17–60 - NCT04255693Recruiting
Real-life reflux study of diet and behavior changes
This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.
MoscowAges 18–80 - NCT04411823Recruiting
Predicting reflux after stomach sleeve surgery
This trial looks at how to predict who will develop acid reflux after a “stomach sleeve” operation. It may help doctors choose the safest plan before surgery and better prevent reflux afterward.
Orlando, FloridaAges 18 years+ - NCT04960566Enrolling by invitation
Behavior therapy for reflux symptoms tied to stress responses
This study tests a behavioral approach for people with GERD whose reflux symptoms keep coming back even after they tried an acid-blocking medicine (a PPI). It aims to help by targeting stress-related body responses that may worsen symptoms.
Chicago, IllinoisAges 18–80 - NCT06255886RecruitingPhase 4
Treatment for acid reflux in babies under 1 year
This trial tests a treatment for babies under 1 year old who have frequent and troublesome reflux (GERD). It aims to find a safe and effective way to reduce symptoms like crying, feeding problems, and breathing pauses.
Aabenraa, Region SyddanmarkAges 1 month–1 year - NCT06613438Recruiting
New wearable device for GERD symptoms
This study tests a new wearable device (eGERD) that aims to reduce symptoms of GERD (heartburn and regurgitation). The trial will check if the device is safe and works well without needing medication.
Chicago, IllinoisAges 22–75 - NCT07252115Recruiting
Comparing two surgeries for hiatal hernia and stubborn GERD
This trial compares two surgical approaches (a 'partial wrap' and a 'full wrap' of the stomach around the esophagus) to fix a hiatal hernia and treat severe, hard-to-control reflux (GERD). It may be a good option if your reflux hasn't improved with medication and you have a hiatal hernia.
BeijingAges 18–85 - NCT07624383Recruiting
New topical treatment for nonerosive acid reflux disease
This study tests a new topical treatment for people with chronic heartburn and acid regurgitation who don't have erosions (damage) in their esophagus. The treatment is applied directly to the affected area and may help relieve symptoms without taking daily pills.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07749989Recruiting
Review of patients with gastroesophageal reflux disease
This study looks at patients who came to Beijing Friendship Hospital with stomach acid issues (GERD). Researchers want to understand how treatments like medications or anti-reflux surgery work over time. By joining, you help them improve care for others with the same condition.
Beijing, Beijing MunicipalityAges 18–90 - NCT03692455Enrolling by invitation
Compare two weight-loss surgeries for reflux over 8 years
This study follows people for up to 8 years to see how two different weight-loss surgeries affect ongoing heartburn and acid reflux. You would join only if you were already enrolled in an earlier related study and can complete required follow-up visits and tests.
Passo Fundo, Rio Grande do SulAges 18–78 - NCT06991348RecruitingPhase 4
Comparing two heartburn medicines: tegoprazan vs pantoprazole
This study tests whether a newer medicine, tegoprazan, works better than an older one, pantoprazole, for treating heartburn and acid reflux. Both are stomach acid reducers. You may be able to join if you have been diagnosed with GERD and your symptoms have lasted for at least three months.
Mexico City, Mexico CityAges 18 years+ - NCT07700342Recruiting
Could an evening gel improve sleep for nighttime reflux?
This trial tests a topical therapy you apply at night to see if it can improve sleep for people with non-erosive GERD who still have nighttime symptoms even while taking a morning acid reducer.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07125521Recruiting
Smartphone app study for GERD medication adherence
This study tests whether using a smartphone app called GERDCare helps people with GERD take their medications as prescribed. It may be a good fit if you have typical GERD symptoms like heartburn or regurgitation and are comfortable using a smartphone app.
HanoiAges 18 years+ - NCT06757296Recruiting
Endoscopic revision of sleeve gastrectomy for reflux or poor weight loss
This study tests a new, less invasive way to convert a sleeve gastrectomy into a different type of weight-loss surgery (SASI) in people who have ongoing gastroesophageal reflux or haven't lost enough weight. The goal is to see if this endoscopic procedure can improve reflux and help with weight loss without the need for a traditional surgery.
SingaporeAges 21–65 - NCT00574327Recruiting
Barrett’s and reflux registry at the Kansas City VA
This study follows people with confirmed Barrett’s esophagus (with or without concerning cell changes) and people who have reflux symptoms, to better understand how these conditions progress. It may help by building a Barrett’s registry so doctors can learn which factors predict worsening over time.
Kansas City, MissouriAges 18 years+ - NCT07754721Recruiting
Diet and lifestyle program for chronic acid reflux
This study tests a comprehensive program that combines diet and lifestyle changes to help people with chronic acid reflux (heartburn, acid regurgitation, or chest pain) feel better. It looks at how these changes can improve your overall health and reduce symptoms.
Hualien City, TaiwanAges 18–79 - NCT05132816Recruiting
Test manometry after partial anti-reflux surgery
This study checks how well a swallowing test called high-resolution manometry works after partial anti-reflux surgery. It focuses on adults with certain abnormal esophagus muscle patterns to help doctors understand what to expect after the operation.
Schlieren, Canton of ZurichAges 18 years+ - NCT06348420Recruiting
New procedure vs. acid-reducing pills for GERD
This study compares a new procedure called anti-reflux mucosal valvuloplasty (ARMV) to acid-reducing medicines (PPIs) for treating GERD. It may help people who have had reflux for a long time and need daily PPIs.
Jinan, ShandongAges 18–60 - NCT06564558Recruiting
Posture correction for GERD symptoms
This study tests whether teaching people with GERD to improve their posture can reduce their symptoms. It is for people with a rounded upper back (kyphosis) and a GERD diagnosis.
BeirutAges 18–60 - NCT06495606Recruiting
How stomach acid affects your voice
This study looks at how stomach acid backing up into the throat can change the voice. It may help find typical voice differences in people with acid reflux.
BernAges 18 years+ - NCT05704348Recruiting
Test to reduce reflux after sleeve stomach surgery
This study looks at whether a treatment plan called “Sleeve-pex” can reduce heartburn and reflux after sleeve gastrectomy. If you’re planning this surgery and can complete symptom questionnaires, you may be able to join and help compare outcomes between groups.
FørdeAges 18 years+ - NCT07131397Recruiting
Breathing muscle training for GERD
This trial tests whether strengthening your breathing muscles can help reduce GERD symptoms. You may be eligible if you have GERD and are in generally good health without other major conditions.
Athens, AtticaAges 18–70
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Gastroesophageal Reflux trials by city
Studies with a site in or near these metro areas.
Gastroesophageal Reflux trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for gastroesophageal reflux?
- Yes. Clin2 currently lists 62 recruiting gastroesophageal reflux studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastroesophageal reflux trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastroesophageal reflux trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.