Clinical trials
Gastrointestinal Cancer clinical trials
Below are recruiting gastrointestinal cancer clinical trials, each written for real people, not researchers. We’re tracking 161 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06202131Recruiting
Blood test for tumor DNA in gastrointestinal cancers
This trial uses a blood test (ctDNA) to look for genetic material from tumors in patients with gastrointestinal cancers. It may help doctors understand and track your cancer better.
Rome, LazioAges 18–85 - NCT06509022Enrolling by invitation
Reflux study after esophageal cancer surgery
This study is for people who have had surgery for esophageal cancer. It uses a special test called PEPTEST to track acid reflux after surgery and find out what affects it.
BeijingAges Any age - NCT06885034RecruitingPhase 1/Phase 2
Testing a New Drug for Advanced Colon, Rectal, or Pancreatic Cancer
This study tests an experimental drug, alone or combined with other treatments, for advanced colon, rectal, or pancreatic cancer that hasn't responded to standard options or cannot be removed by surgery. The goal is to see if it is safe and if it helps shrink or slow the cancer.
Los Alamitos, CaliforniaAges 18 years+ - NCT07712107Recruiting
Gastrointestinal Cancer Screening Study Using Combined Detection
This study tests a new way to screen for stomach and digestive cancers using a combination of tests. It compares different screening plans to see which works best for people in their middle years.
Zhaoqing, GuangdongAges 45–74 - NCT06028737RecruitingPhase 2/Phase 3
Chemotherapy before surgery for advanced stomach cancer
This trial tests a combination of chemotherapy drugs given before surgery for locally advanced stomach or gastroesophageal junction cancer. It aims to see if this approach helps shrink the tumor and improve outcomes.
VilniusAges 18–80 - NCT06101277Recruiting
Local therapy for limited new cancer growth in digestive cancers
This trial tests a cancer treatment that uses local therapies (like radiation or targeted heat) to destroy a small number of growing spots. It is for people with certain gastrointestinal cancers whose main treatment is working well except for a few new spots, so they can avoid switching to a different drug right away.
Sacramento, CaliforniaAges 18 years+ - NCT07412379Recruiting
Predicting recovery after cancer surgery for older adults
This study looks at how older adults (65+) with digestive tract cancers respond to surgery aimed at a cure. Researchers want to see what factors affect recovery and quality of life after the operation.
BogotáAges 65 years+ - NCT04221893Recruiting
Radiation for tumors that keep growing despite immunotherapy
This study tests whether targeted radiation can help people with metastatic gastrointestinal cancers whose cancer is still getting worse on immunotherapy. It focuses on treating a small number of spots that are progressing while keeping other spots that are safer to leave alone.
San Francisco, CaliforniaAges 18 years+ - NCT07224750Recruiting
A blood test to find early signs of gastrointestinal cancer
This study is testing a blood-based test to detect unique molecules (called miRNAs) that may signal the presence of several types of gut or digestive system cancers. The goal is to develop a simple screening tool that could catch these cancers earlier.
Duarte, CaliforniaAges 18 years+ - NCT04629677Recruiting
Portal vein stent for narrowed portal blood vessels
This trial looks at whether placing a small metal stent in the portal vein and nearby veins can improve problems caused by major narrowing (or clotting) of these vessels in people with gastrointestinal cancers. If you have significant vessel narrowing, the study may offer a targeted way to relieve pressure and symptoms that are not caused by the tumor directly.
Houston, TexasAges 18 years+ - NCT06118437Recruiting
Gastrointestinal cancer screening prediction study
This study aims to build a model to predict your risk of gastrointestinal cancer based on personal risk factors. It involves having both an upper endoscopy (gastroscopy) and a colonoscopy at the same time.
Xi'an, ShaanxiAges 18–80 - NCT03800693RecruitingPhase 2
Shorter vs longer oxaliplatin infusions for gut cancer
This Phase 2 study compares giving oxaliplatin by IV for 2 hours versus 6 hours, along with the standard FOLFOX6 chemotherapy. It aims to see if the shorter infusion works as well and is manageable for people with gastrointestinal cancers.
Atlanta, GeorgiaAges 18 years+ - NCT03866525RecruitingPhase 1/Phase 2
Test an oncolytic virus treatment for solid tumors
This early-stage study tests a virus therapy designed to attack solid tumors that cannot be removed by surgery or have returned/spread. It may help shrink tumors and control cancer in people whose standard treatments are no longer working.
Beijing, Beijing MunicipalityAges 18–75 - NCT04534543Recruiting
Imaging scans to personalize chemotherapy for liver spread of bowel cancer
This trial tests whether special liver imaging can help doctors choose or guide the best chemotherapy for people with liver metastases from gastrointestinal cancer. The study focuses on comparing imaging-based information with outcomes during common chemo treatments like CAPOX or FOLFOX.
AmsterdamAges 18 years+ - NCT04782557Recruiting
Ultrasound-guided blood sampling to track cancer DNA
This study uses an ultrasound-guided procedure to collect blood and check for cancer DNA (small bits of tumor material in the bloodstream). It aims to see whether this method can better track how gastric, pancreatic, or colorectal cancer responds to treatment.
Hong KongAges Any age - NCT05547919Recruiting
PSMA scan study for newly diagnosed gut cancer
This study looks at a specific body scan target (PSMA) in newly diagnosed gut cancers to better understand the tumor and guide future care. You may be asked to provide tumor tissue and get a PSMA PET/CT scan, and the results could help identify who may benefit from PSMA-based treatments.
Würzburg, BavariaAges 18 years+ - NCT06015971Recruiting
Omega-3 and nutrition support for gastrointestinal cancer
This trial tests whether adding omega-3 fatty acids and extra nutrition support can help people with gastrointestinal cancer who have lost weight. It aims to improve strength and well-being during treatment.
Córdoba, CordobaAges 18 years+ - NCT06104241RecruitingEarly Phase 1
Cell therapy for advanced digestive cancers
This trial tests a new cell therapy called BGT007 for people with advanced cancers of the digestive system (esophagus, stomach, pancreas, or colon) that have not responded to standard treatments. The therapy uses your own immune cells, modified to target a protein on your cancer cells.
Xuzhou, JangSuAges 18–70 - NCT06569693Recruiting
Sleep study for people with GI cancer and their partners
This study tests whether couples (one with a GI cancer and their sleep partner) can improve their sleep together. It involves a sleep program to help both partners build healthier sleep habits.
Coral Gables, FloridaAges 18 years+ - NCT07281248Recruiting
Prehabilitation before gastrointestinal cancer surgery
This trial tests a program of exercise, nutrition, and mindfulness before surgery for gastrointestinal cancer. It aims to help you recover better after your operation.
Madrid, MadridAges 18 years+ - NCT07456852RecruitingPhase 1/Phase 2
Can vasodilators help with chemo side effects in GI cancer?
This trial tests two drugs (isosorbide mononitrate and diltiazem) to see if they can prevent blood vessel damage caused by chemotherapy drugs like 5-FU or capecitabine in people with gastrointestinal cancers.
Rochester, MinnesotaAges 18 years+ - NCT07406633RecruitingPhase 2
KQB198 plus imatinib for advanced GIST
This trial tests a new drug called KQB198 combined with imatinib for people with advanced or metastatic gastrointestinal stromal tumor (GIST) that has a specific KIT or PDGFRA mutation. The goal is to see if this combination works better than imatinib alone as a first treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT07501663Recruiting
Managing nerve damage from chemo in GI cancer survivors
This study tests different integrative approaches (like acupuncture or supplements) to help GI cancer survivors manage nerve damage from chemotherapy. You may be able to join if you have ongoing numbness and tingling from chemo.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03848962Recruiting
Share leftover or collected samples for research
This study helps collect and share human samples (like blood or other specimens) so researchers can do new studies. It’s mainly about providing samples for research use, not testing a treatment on you.
Huntsville, AlabamaAges 1 month–89 years
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Common questions
- Are there clinical trials for gastrointestinal cancer?
- Yes. Clin2 currently lists 161 recruiting gastrointestinal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastrointestinal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastrointestinal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Gastrointestinal Cancer Metastatic
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Cancer of Gastrointestinal Tract
- Upper Gastrointestinal Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.