Clinical trials
Glioblastoma clinical trials
Below are recruiting glioblastoma clinical trials, each written for real people, not researchers. We’re tracking 317 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07616986Recruiting
Laser heat treatment for early-returning brain cancer
This trial tests a minimally invasive laser procedure (LITT) to treat glioblastoma that comes back very soon after initial treatment. The goal is to see if laser heat can destroy the tumor before standard radiation and chemotherapy begin, potentially improving outcomes.
BernAges 18 years+ - NCT07627334Recruiting
Personalized drug testing for newly diagnosed brain tumors
This trial tests whether customized drug screening on your tumor cells can help doctors choose the best treatment for you. Your tumor cells will be grown in the lab and tested against different drugs to find what works best, combined with short-course radiation therapy.
Vienna, State of ViennaAges Any age - NCT07670026RecruitingPhase 2
Stronger treatment after surgery for high-risk glioblastoma
This trial tests a more intense chemotherapy plan for people with glioblastoma who had only partial removal of their tumor or whose tumor grew back quickly. The goal is to see if this approach can improve outcomes.
Hangzhou, ZhejiangAges 18 years+ - NCT07634575Enrolling by invitation
Smart imaging for newly diagnosed brain cancer
This study tests whether imaging scans can be timed based on your symptoms and progress, rather than on a fixed schedule. The goal is to make monitoring easier while keeping you safe during standard brain cancer treatment.
LondonAges 18 years+ - NCT07417774Enrolling by invitation
Blood test monitoring for glioblastoma treated with chemoradiation and oxygen therapy
This substudy looks at a blood test (liquid biopsy) to track glioblastoma during standard chemoradiation and an experimental oxygen-boosting drug. It aims to see if the test can help monitor the tumor more easily than scans alone.
Tucson, ArizonaAges 18 years+ - NCT07130149Enrolling by invitationPhase 2
Sonodynamic therapy plus chemoradiation for glioblastoma
This trial combines a new therapy (sonodynamic therapy) with standard radiation and chemotherapy for glioblastoma. It aims to see if this approach is safe and how well it works for people who have just been diagnosed and had surgery.
Zhengzhou, HenanAges Up to 75 years - NCT05908669Enrolling by invitation
MRI tracking of radiotherapy changes in newly diagnosed brain cancer
This study uses special MRI imaging with deuterium to see how radiotherapy affects newly diagnosed glioblastoma (GBM) with an IDH-wildtype tumor. It may help doctors better understand treatment response and timing, potentially improving how radiotherapy is planned.
AarhusAges 18 years+ - NCT05116137Enrolling by invitation
Exercise therapy to build muscle after glioblastoma
This trial studies whether a resistance (strength-building) exercise program can help survivors of glioblastoma keep or increase their muscle mass. If you are able to safely exercise, it may support recovery and overall strength after treatment.
Halifax, Nova ScotiaAges 18 years+ - NCT03170141Enrolling by invitationPhase 1
T-cell therapy for recurrent brain tumor
This Phase 1 study tests modified immune T-cells to treat recurrent glioblastoma (a fast-growing brain tumor) that can be seen on scans. Because it’s early-stage, the goal is mainly safety, but you may be helping researchers understand if the treatment can shrink tumors.
Shenzhen, GuangdongAges 6–70 - NCT04047264Recruiting
Monitoring brain chemistry during brain surgery
This study tests whether a tiny probe can safely measure brain chemistry during and after brain surgery. It may help doctors better understand and treat brain conditions like tumors or epilepsy.
Rochester, MinnesotaAges 18 years+ - NCT06319027RecruitingPhase 2
Can brain scans help predict glioblastoma progression?
This trial is testing whether certain details on brain scans can help doctors better predict how brain cancer (glioblastoma) will progress. You may be eligible if you are newly diagnosed with this type of cancer and plan to receive standard treatment.
Birmingham, AlabamaAges 18 years+ - NCT06492486RecruitingPhase 2
Brain tumor radiation study using AI planning
This trial tests a new way to plan radiation therapy for brain tumors (gliomas) using artificial intelligence. It aims to make treatment more precise and personalized for people with either aggressive (GBM) or slower-growing (IDH-mutant) gliomas.
Mumbai, MaharatshtraAges 18–70 - NCT06161519RecruitingPhase 1/Phase 2
PLX038 for brain tumors with MYC or MYCN changes
This study tests a new drug called PLX038 for people with brain or spinal cord tumors that have certain genetic changes (MYC or MYCN) or have come back after treatment. The drug is given as an infusion and targets tumor cells. The study aims to see if the drug is safe and effective for different types of these tumors.
Bethesda, MarylandAges 18–120 - NCT07544992RecruitingPhase 1
CAR T Cells for Recurrent High-Grade Brain Tumors
This trial tests genetically engineered immune cells (CAR T cells) injected directly into the brain to treat recurring or worsening high-grade gliomas. The cells are designed to recognize and attack tumor cells that have specific markers (EGFR and IL13Rα2).
Duarte, CaliforniaAges 18 years+ - NCT07074756Recruiting
Home-based treatment support for people with glioma
This study tests a digital platform that helps you manage your glioma treatment at home. It aims to make it easier to follow your treatment plan and stay connected with your care team.
Jacksonville, FloridaAges 18 years+ - NCT07195591RecruitingPhase 3
Starting radiation during brain cancer surgery vs. standard treatment
This trial tests putting radiation directly into the brain right after surgery for glioblastoma, instead of waiting for standard radiation later. It aims to see if this approach works better and is safe for you.
Scottsdale, ArizonaAges 18 years+ - NCT05086497Recruiting
Personal TTFields device guided by imaging for brain tumor
This trial tests whether using a personalized TTFields device—placed based on imaging—can help treat adults with glioblastoma (GBM) after surgery and radiation. It’s designed for specific GBM genetic types and may help deliver therapy more precisely.
Philadelphia, PennsylvaniaAges 22 years+ - NCT04115761RecruitingPhase 2
ADCv01 added to standard care for newly diagnosed glioblastoma
This Phase 2 study tests ADCV01, given “on top of” other standard treatment, for newly diagnosed glioblastoma (grade 4 brain tumor). The goal is to see whether it helps patients live longer and safely manage tumor growth.
Taichung, Non-USAges 20–75 - NCT07655869RecruitingEarly Phase 1
Lu177-DOTA-EB-RGD2 therapy for returning high-grade glioma
This trial tests a radioactive drug that targets a protein on tumor blood vessels to treat glioblastoma that has come back after standard treatment. It may help shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06883747RecruitingEarly Phase 1
Study of BMS-986504 for recurrent brain tumor
This trial tests an experimental drug, BMS-986504, for people with recurrent glioblastoma (a type of brain cancer). The drug targets a specific genetic change in the tumor. It aims to see if the drug can help shrink or slow the tumor.
Phoenix, ArizonaAges 18 years+ - NCT03643549RecruitingPhase 1/Phase 2
Combination treatment for recurring brain cancer
This trial tests a combination of two drugs, bortezomib and temozolomide, for people whose brain tumor (glioblastoma) has returned after initial treatment. It's designed for tumors that don't respond well to standard treatments, and the goal is to see if this combination can help control the cancer.
BergenAges 18 years+ - NCT07731555Recruiting
Studying the brain barrier in glioblastoma
This study looks at how the brain's protective barrier works in people with glioblastoma. Researchers will study tumor tissue and use special scans to learn more, which might help improve future treatments.
BeaumontAges 18 years+ - NCT06814496RecruitingPhase 1/Phase 2
Radiation and immunotherapy combo for DLL3-positive cancers
This trial combines radiation with an immunotherapy drug called tarlatamab to treat cancers that make a protein called DLL3. The goal is to see if this combination works better than either treatment alone for people with certain types of lung cancer and other tumors that have not responded to prior therapy.
Tucson, ArizonaAges 18–99 - NCT04479696Recruiting
Video coaching to ease anxiety during brain tumor radiation
This study tests a personalized video meant to reduce stress and anxiety for people getting radiation for brain tumors, and for their caregivers. You and your caregiver would complete short questionnaires before and after using the video support.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for glioblastoma?
- Yes. Clin2 currently lists 317 recruiting glioblastoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioblastoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioblastoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.