Clinical trials
Recurrent Glioblastoma clinical trials
Below are recruiting recurrent glioblastoma clinical trials, each written for real people, not researchers. We’re tracking 109 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07318818RecruitingPhase 1/Phase 2
Revised cell therapy for recurrent brain cancer
This trial tests a new cell therapy (P134 cells) for people whose glioblastoma has come back after standard treatments like radiation or chemotherapy. The therapy uses a patient's own immune cells (PBMCs) to target cancer cells that have specific markers (CD44 or CD133). It also requires a small procedure to place a reservoir under the scalp for drug delivery.
BeijingAges 18–70 - NCT07416188RecruitingPhase 1/Phase 2
LMP744 drug for returning glioblastoma
This trial tests an experimental drug called LMP744 for people whose glioblastoma has come back. It aims to see if the drug can slow or stop tumor growth by targeting specific proteins in cancer cells.
Bethesda, MarylandAges 18–99 - NCT07089641RecruitingPhase 1
Testing a new pill for EGFR-mutated glioblastoma
This trial tests a new pill called ERAS-801 for people with a type of brain tumor (glioblastoma) that has a specific change in the EGFR gene. The study is for patients whose tumor has come back after treatment, or for those 70 or older who are newly diagnosed.
Los Angeles, CaliforniaAges 18 years+ - NCT04559230RecruitingPhase 2
Treating recurrent glioblastoma with sacituzumab govitecan
This Phase 2 study tests sacituzumab govitecan in adults whose glioblastoma has come back after standard treatment (radiation plus temozolomide). It may help shrink the tumor in people whose tumor has a specific target (Trop-2).
Cleveland, OhioAges 18 years+ - NCT04590664RecruitingPhase 1/Phase 2
Verteporfin for recurrent EGFR-mutant glioblastoma
This trial tests verteporfin (Visudyne), given through a vein, for recurrent glioblastoma that has an EGFR mutation or increased EGFR. It aims to shrink or slow the tumor after standard treatment has already been tried.
Atlanta, GeorgiaAges 18 years+ - NCT05284643Recruiting
MRI-guided radiation and Avastin for recurrent brain glioblastoma
This trial tests whether using special MRI information to plan proton radiation, plus a drug called Avastin (bevacizumab), can help control recurrent glioblastoma (a fast-growing brain tumor) and improve outcomes. It mainly aims to treat tumor that has come back after prior standard radiation, using careful timing and imaging to target it safely.
Miami, FloridaAges 18 years+ - NCT05303467RecruitingPhase 1
Safety study of a glioblastoma device for recurring tumors
This early study tests whether a device called TheraSphere is safe when delivered into the brain to treat recurrent glioblastoma. It may help patients by trying a targeted treatment approach, while doctors carefully monitor side effects and safety.
Birmingham, AlabamaAges 18 years+ - NCT05432518RecruitingEarly Phase 1
Pilot study for surgery and new medicine in recurrent glioblastoma
This early study looks at a treatment plan (including resection/surgery and an added medicine) for glioblastoma that has come back after standard therapy. The goal is to see how well it controls tumor growth and whether it is tolerable.
Calgary, AlbertaAges 18 years+ - NCT05577091RecruitingPhase 1
CAR-T cell therapy for recurrent glioblastoma
This early-phase trial studies a personalized immune-cell treatment (CAR-T) for glioblastoma that has come back. It aims to shrink or control the regrowing brain tumor by using your own immune cells after processing them in a lab.
Beijing, Beijing MunicipalityAges 18–70 - NCT05660369RecruitingPhase 1
CAR T-cell treatment for EGFR-mutant glioblastoma
This Phase 1 trial tests a new immune treatment made from your own immune cells to attack glioblastoma (a brain tumor), especially tumors with a specific EGFR change called EGFRvIII. It mainly focuses on safety and early signs of effectiveness, and some participants will also need surgery/biopsy and an implanted port for the treatment.
Boston, MassachusettsAges 18 years+ - NCT05789394RecruitingPhase 1
Stem cell treatment for recurrent brain tumor surgery
This Phase 1 study tests an “allogenic” stem cell product made from donated fat tissue to treat recurrent glioblastoma or certain recurrent astrocytoma. It gives the treatment around the time of a repeat brain surgery, and focuses on safety while also studying why it might help.
Jacksonville, FloridaAges 18 years+ - NCT06097975RecruitingPhase 1
Combined immunotherapy for recurrent glioblastoma
This trial combines two immunotherapy drugs (ipilimumab and nivolumab) given through a vein and directly into the brain for people with recurrent glioblastoma. The goal is to see if this approach can help control the tumor.
BrusselsAges 18 years+ - NCT06160206RecruitingPhase 2
Study of retifanlimab, bevacizumab, and radiation for recurrent glioblastoma
This trial tests a combination of immunotherapy (retifanlimab), a targeted drug (bevacizumab), and low-dose radiation for people whose glioblastoma has come back. The goal is to see if this treatment can help shrink or slow the tumor.
Scottsdale, ArizonaAges 18 years+ - NCT06220552RecruitingPhase 2
Low-dose radiation plus immunotherapy for recurrent glioblastoma
This trial tests a combination of low-dose radiation, an immunotherapy drug (sintilimab), and chemotherapy (temozolomide) for people with glioblastoma that has come back. The goal is to see if this approach can help control the tumor and improve survival.
Zhuhai, GuangdongAges 18 years+ - NCT06273176Recruiting
Surgery with or without brain mapping for recurrent glioblastoma
This study is testing whether using a special brain-mapping technique during surgery helps people with recurrent glioblastoma. It compares standard surgery to surgery with mapping to see if it leads to better outcomes for tumors near important brain areas.
San Francisco, CaliforniaAges Up to 90 years - NCT06283927Recruiting
Surgery vs. medical care for recurrent glioblastoma
This trial compares surgery to the best non-surgical treatment for people whose glioblastoma has come back. The goal is to see which approach helps people live longer with a better quality of life.
San Francisco, CaliforniaAges 18–90 - NCT06410248RecruitingPhase 1
Triapine and temozolomide for recurrent glioblastoma
This trial tests a combination of two drugs, triapine and temozolomide, for people whose glioblastoma has come back after initial treatment. The goal is to see if this combination can help control the tumor.
Chicago, IllinoisAges 18 years+ - NCT06552260RecruitingEarly Phase 1
Troriluzole before surgery for recurrent glioblastoma
This trial tests whether an investigational drug called troriluzole can help people with recurrent glioblastoma (a type of brain tumor). You would take the drug for a short time before your planned surgery, so researchers can study how the drug affects your tumor tissue. The goal is to see if it might slow tumor growth.
Boston, MassachusettsAges 18 years+ - NCT06598787RecruitingPhase 2
Study of a new drug for recurrent glioblastoma
This trial tests a new drug called BL-B01D1 for people whose glioblastoma has come back after standard treatment. The goal is to see if the drug can help control the tumor.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06613841RecruitingEarly Phase 1
Brain tumor imaging study for glioblastoma patients
This study uses special PET scans (fluciclovine and FDG) and advanced MRI to create a detailed metabolic profile of glioblastoma. It may help doctors better understand your tumor before surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06910306Recruiting
DaRT alpha radiation for recurrent glioblastoma
This trial tests a device called DaRT that delivers alpha radiation directly to a recurrent glioblastoma tumor. It may help patients who cannot have surgery and have a single, small tumor regrowth.
Scottsdale, ArizonaAges 18–85 - NCT06917885RecruitingPhase 1
CUE-102 for Recurrent Glioblastoma: A Safety Study
This study tests an experimental drug, CUE-102, for people with recurrent glioblastoma. It aims to see if the drug is safe and how well it works. You may be eligible if your tumor has come back once, you have a specific genetic marker (HLA-A*0201), and you are not on other treatments.
Boston, MassachusettsAges 18 years+ - NCT07076472RecruitingEarly Phase 1
Sound and drug therapy for recurrent glioblastoma
This trial tests a new approach that combines a drug (SONALA-001 or 5-ALA) with focused ultrasound to treat glioblastoma that has come back or is growing despite standard treatments. The drug makes tumor cells sensitive to sound waves, and the ultrasound waves are directed at the tumor using MRI guidance. This may help damage cancer cells while sparing healthy brain tissue.
Rochester, MinnesotaAges 18 years+ - NCT07297212RecruitingPhase 2
Testing the drug pumitamig for recurrent glioblastoma
This trial tests an investigational drug called pumitamig (also known as BNT327) in people whose glioblastoma has come back after standard treatment with radiation and temozolomide. The goal is to see if the drug is safe and whether it can help slow or stop tumor growth.
BeijingAges 18–75
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Recurrent Glioblastoma trials by city
Studies with a site in or near these metro areas.
Recurrent Glioblastoma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for recurrent glioblastoma?
- Yes. Clin2 currently lists 109 recruiting recurrent glioblastoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a recurrent glioblastoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a recurrent glioblastoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.