Clinical trials
Glioma Glioblastoma Multiforme clinical trials
Below are recruiting glioma glioblastoma multiforme clinical trials, each written for real people, not researchers. We’re tracking 48 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06810544RecruitingPhase 1/Phase 2
Study of TNG456 for tumors with MTAP loss
This trial tests a new drug called TNG456, alone or with another drug (abemaciclib), for people whose tumors have lost the MTAP gene. It aims to see if the combination can shrink tumors or slow their growth.
Scottsdale, ArizonaAges 18 years+ - NCT07179328RecruitingPhase 1
Focused ultrasound for glioblastoma during standard chemo
This trial tests whether focused ultrasound can safely open the blood-brain barrier to help your chemotherapy work better. It is for people with glioblastoma who have already completed standard surgery and chemo-radiation and are now on maintenance chemo.
Toronto, OntarioAges 18–85 - NCT07464925RecruitingPhase 1
Testing GLIX1 for adults with returning high-grade glioma
This trial tests a new drug called GLIX1 to find a safe dose for people whose high-grade glioma (a fast-growing brain tumor) has come back or is getting worse after earlier treatments. It may be an option if you've had no more than two prior treatments.
Tampa, FloridaAges 18 years+ - NCT07567196Recruiting
PET imaging to guide surgery for aggressive brain tumors
This trial tests whether using a special PET scan (a type of imaging that shows tumor activity) during brain tumor surgery helps doctors remove more of the tumor safely. You would have a high-grade glioma (an aggressive brain cancer) and be scheduled for surgery.
Torino, TurinAges 18 years+ - NCT07608003Recruiting
MRI AI model study for midline brain tumors
This study uses artificial intelligence to analyze MRI scans of midline brain tumors (gliomas) to help predict how the disease may progress and improve treatment planning. Researchers are collecting data from multiple hospitals to teach an AI system to better understand these tumors.
Changsha, HunanAges Any age - NCT06418113RecruitingPhase 1
Radiation and chemo before surgery for glioblastoma
This trial tests giving radiation and chemotherapy before surgery for glioblastoma. It aims to see if this approach is safe and may help improve outcomes for patients whose tumor can be completely removed.
MadridAges 18–75 - NCT06011109RecruitingPhase 1/Phase 2
APG-157 plus Avastin for recurrent high-grade glioma
This trial tests a combination of two drugs—APG-157 (an oral plant-based medicine) and bevacizumab (Avastin)—for people with recurrent high-grade brain tumors that have already been treated with standard therapies. The goal is to see if adding APG-157 can help control the tumor better.
Rochester, MinnesotaAges 19 years+ - NCT05500612Recruiting
MRI oxygen scan study for glioblastoma during radiation treatment
This study uses special MRI scans to measure oxygen levels in and around glioblastoma before and during radiation treatment. It may help researchers understand how oxygen affects treatment response and timing.
St Leonards, New South WalesAges 18 years+ - NCT05086497Recruiting
Personal TTFields device guided by imaging for brain tumor
This trial tests whether using a personalized TTFields device—placed based on imaging—can help treat adults with glioblastoma (GBM) after surgery and radiation. It’s designed for specific GBM genetic types and may help deliver therapy more precisely.
Philadelphia, PennsylvaniaAges 22 years+ - NCT05353530RecruitingPhase 1
CAR T cell treatment for CD70-positive newly diagnosed glioblastoma
This trial tests a customized immune-cell treatment (CAR T cells) for adults with newly diagnosed glioblastoma (GBM) whose tumors have enough CD70 protein. If you qualify, the goal is to see whether this treatment can better control the cancer by targeting it in the brain.
Gainesville, FloridaAges 18–80 - NCT07391215RecruitingPhase 1/Phase 2
Paxalisib for newly diagnosed glioblastoma after standard treatment
This trial tests a drug called paxalisib in people with a newly diagnosed aggressive brain tumor (glioblastoma) who have just finished standard radiation and chemotherapy. The goal is to see if adding paxalisib can help prevent the tumor from coming back by targeting a specific pathway in the cancer cells.
SuttonAges 16 years+ - NCT06273176Recruiting
Surgery with or without brain mapping for recurrent glioblastoma
This study is testing whether using a special brain-mapping technique during surgery helps people with recurrent glioblastoma. It compares standard surgery to surgery with mapping to see if it leads to better outcomes for tumors near important brain areas.
San Francisco, CaliforniaAges Up to 90 years - NCT05450744RecruitingPhase 1
Radioactive imaging drug trial after surgery for glioblastoma
This Phase 1 trial tests a radioactive medicine (131I-TLX-101) in people with newly diagnosed glioblastoma after tumor surgery. The goal is to see how the drug works and whether it’s safe, especially for identifying or targeting the tumor area to help with treatment planning.
Sydney, New South WalesAges 18 years+ - NCT05756985Recruiting
Providing fresh brain tissue to better understand glioblastoma
This study aims to improve understanding of glioblastoma (and gliosarcoma) by preserving live, usable brain-tissue samples during brain surgery. If you’re having repeat tumor surgery or your scans suggest these cancers, the study may ask to collect tissue for research.
Miami, FloridaAges 18 years+ - NCT05956821RecruitingPhase 1/Phase 2
Study drug for young people with recurring brain glioma
This Phase 1/2 trial tests a study treatment for children and young adults under 22 whose brain glioma has come back or isn’t responding to prior treatment. It’s designed to see whether the treatment is safe and effective for shrinking tumors in this situation.
Miami, FloridaAges 1–21 - NCT04188535Recruiting
MRI scans during radiation treatment
This study does repeated MRI (detailed brain/body imaging) while you receive radiation therapy. It aims to see how these serial scans relate to treatment and outcomes, which could help improve care planning for different cancers.
Boston, MassachusettsAges 18 years+ - NCT04115761RecruitingPhase 2
ADCv01 added to standard care for newly diagnosed glioblastoma
This Phase 2 study tests ADCV01, given “on top of” other standard treatment, for newly diagnosed glioblastoma (grade 4 brain tumor). The goal is to see whether it helps patients live longer and safely manage tumor growth.
Taichung, Non-USAges 20–75 - NCT04765514RecruitingPhase 2
Chemo with radiation versus chemo alone for older brain tumor patients
This trial compares two standard treatments for newly diagnosed glioblastoma (a serious brain cancer) in older and frail patients: chemo plus radiation versus chemo alone. It may help determine which approach works best and is safest for people in your age and health group.
Calgary, AlbertaAges 65 years+ - NCT04780009Recruiting
Imaging tool during brain tumor surgery
This trial tests a special camera system used during surgery to help doctors see brain tumor tissue using fluorescent light. It may help the surgeon remove more tumor while protecting healthy brain areas.
Lexington, KentuckyAges 18–90 - NCT05084430RecruitingPhase 1/Phase 2
Pembrolizumab plus M032 for recurrent brain tumors
This early-phase study tests the safety and early signs of benefit of combining pembrolizumab with M032 in people with certain aggressive brain tumors. You may be considered if you have a glioma tumor that can potentially be removed by surgery.
Birmingham, AlabamaAges 18 years+ - NCT05366179RecruitingPhase 1
Personalized CAR-T therapy for recurring brain tumor
This Phase 1 study tests a personalized immune-cell treatment (CAR-T) made from your own cells to attack a marker called B7-H3 on recurring glioblastoma. It may help shrink or control the tumor, but the main goal is to check safety and how the treatment works.
Chapel Hill, North CarolinaAges 18 years+ - NCT05474378RecruitingPhase 1
CAR T cell therapy for recurrent glioblastoma
This early-phase study tests a type of immune-cell treatment (CAR T cells) aimed at a target called B7-H3 in people with glioblastoma or related grade 4 brain tumors that have come back. It’s meant to see if the treatment can shrink the tumor or control the disease and to learn how safe it is.
Palo Alto, CaliforniaAges 18 years+ - NCT06926075RecruitingPhase 1/Phase 2
Early trial of KESONOTIDE™ for solid tumors
This trial tests a new tablet called KESONOTIDE™ for people with solid tumors that have spread. The goal is to see if it can help when other treatments have stopped working or are not an option.
Kogarah, New South WalesAges 18 years+ - NCT02800486RecruitingPhase 2
Targeted antibody plus repeat radiation for recurrent brain tumors
This trial studies giving cetuximab (a targeted antibody) directly into an artery along with repeat radiation to treat certain recurring or treatment-resistant brain tumors. It may help by delivering the drug more directly to tumor areas and testing whether this approach can control the disease after it comes back.
New York, New YorkAges 18 years+
Hear when a new Glioma Glioblastoma Multiforme trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for glioma glioblastoma multiforme?
- Yes. Clin2 currently lists 48 recruiting glioma glioblastoma multiforme studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioma glioblastoma multiforme trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioma glioblastoma multiforme trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.