Clinical trials
Head and Neck Cancer clinical trials
Below are recruiting head and neck cancer clinical trials, each written for real people, not researchers. We’re tracking 618 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04673981Recruiting
Follow-up study for oral and throat cancer pain
This study looks at nerve-related symptoms and pain in the mouth and throat in people who have been treated for oral or oropharynx cancer. You may be able to take part if you’re within 1 to 5 years after treatment and can follow study steps.
Clermont-FerrandAges 18 years+ - NCT06545331RecruitingPhase 1
A study of XB010 for advanced solid tumors
This trial tests an investigational drug called XB010 for people with solid tumors that have spread or cannot be removed by surgery. It aims to see if XB010 is safe and effective for several cancer types, including lung, breast, head and neck, and esophageal cancers.
Irvine, CaliforniaAges 18 years+ - NCT06532279RecruitingPhase 2
Testing BMX-001 with chemoradiation for head and neck cancer
This trial tests whether adding BMX-001 (a drug that may protect healthy tissues) to standard chemoradiation can reduce side effects and improve outcomes for people with head and neck cancer. It's a randomized study, so you would have a 50/50 chance of getting BMX-001 or a placebo.
Gilbert, ArizonaAges 18 years+ - NCT06479811RecruitingPhase 1
Radioactive drug for advanced neuroendocrine and other cancers
This early-stage trial tests a new radioactive drug (called [212Pb]VMT-Alpha-NET) that targets a marker on certain cancer cells. It may help shrink or slow the growth of tumors that have spread or can't be removed, and it's being studied for several cancer types, including neuroendocrine tumors, small cell lung cancer, kidney cancer, and some head and neck cancers.
Bethesda, MarylandAges 18–120 - NCT05107674RecruitingPhase 1
Early drug study for advanced cancers that have limited options
This Phase 1 study tests NX-1607 in adults with advanced cancers that are hard to treat with standard care. It focuses on safety and early signs of how well the drug may work in specific cancer types.
Duarte, CaliforniaAges 18 years+ - NCT06477692RecruitingPhase 2
Comparing Neck Radiation Options for Head and Neck Cancer
This trial is testing whether radiation to just the lymph nodes near the tumor is as effective as treating a larger area of the neck. It is for people with certain head and neck cancers (not unknown primary or glottic) and aims to lower side effects.
Dallas, TexasAges 18–99 - NCT04805528Recruiting
Electrical stimulation to reduce dry mouth after head-neck radiation
This trial tests a non-invasive, acupuncture-like electrical stimulation treatment (ALTENS) to help reduce dry mouth after radiation for head and neck cancers. You may qualify if you have bothersome dry mouth and had significant head-neck radiation, with no signs of active cancer and if you can come for treatments over 12 weeks.
Rochester, New YorkAges 18 years+ - NCT06444815RecruitingPhase 1
Study of VET3-TGI for advanced solid tumors
This trial tests an experimental treatment called VET3-TGI, which is injected directly into tumors. It is for people with advanced solid tumors who have already tried other treatments and are looking for new options.
Los Angeles, CaliforniaAges 18 years+ - NCT05757817Recruiting
New flap surgery for mouth or throat cancer reconstruction
This trial studies whether a new surgical reconstruction method can improve outcomes for people with oral cavity or oropharyngeal squamous cell carcinoma (a type of head and neck cancer). The goal is to rebuild the area using a tissue flap while reducing problems where the tissue is taken from.
MontpellierAges 18 years+ - NCT03958240Recruiting
Study how cancers trigger the immune system
This study looks at what makes some cancers more “noticeable” to the immune system. It may help researchers design better future immunotherapy by collecting information (often including blood samples) from people with different cancers.
ToulouseAges 18 years+ - NCT05838729RecruitingPhase 1/Phase 2
RiMO-301 plus radiation with PD-1 therapy for head-neck cancer
This trial studies RiMO-301 injection combined with palliative radiation and a PD-1 immune therapy (pembrolizumab or nivolumab) for head and neck cancer that cannot be fully removed. It aims to see whether this approach can shrink tumors and improve outcomes safely.
Chicago, IllinoisAges 18 years+ - NCT06385080RecruitingPhase 1/Phase 2
Study of amivantamab for head and neck cancer
This trial tests a drug called amivantamab, either alone or with other treatments, for people with head and neck cancer that has spread or come back. The goal is to see if the drug can help shrink tumors or control the cancer.
La Jolla, CaliforniaAges 18 years+ - NCT06385132Recruiting
Studying mental health in brain and head/neck cancer
This study looks at the emotional and mental health of people with glioblastoma (a type of brain tumor) or head and neck cancer who are getting a long course of radiation therapy. The goal is to understand how they are feeling so doctors can provide better support.
RomaAges 18–75 - NCT00900419Recruiting
Check biomarkers during bronchoscopy in breathing and throat pre-cancer
This study looks at “biomarkers” (measurable signals in samples) taken during bronchoscopy or related procedures in people with severe airway pre-cancer or certain lung/throat cancers, and in healthy volunteers. The goal is to better understand what these biomarkers mean and how they might help with diagnosis, staging, or monitoring.
Aurora, ColoradoAges 21–90 - NCT06344208Recruiting
Predicting side effects in older adults with head and neck cancer
This trial studies how to predict side effects (toxicity) in older adults (70+) with advanced head and neck cancer. It tests standard treatments like radiation, chemoradiation, or radiation with cetuximab and aims to help doctors tailor care to reduce harm.
Milan, MilanAges 70–99 - NCT06297902Recruiting
PET-guided Radiation for Head and Neck Cancer
This trial tests a new way to give radiation therapy for head and neck cancer. By using a special PET scan to guide where higher radiation doses are given, doctors hope to improve treatment while reducing side effects. It is for people whose cancer is not early-stage and who will receive standard radiation therapy.
BergenAges 18 years+ - NCT06239220RecruitingPhase 2
Combination immunotherapy for advanced head and neck cancer
This trial tests a combination of three immunotherapy drugs (PD-L1 t-haNK, NAI IL-15sa, and cetuximab) for people with head and neck squamous cell carcinoma that has spread or cannot be cured. The goal is to see if this treatment can shrink tumors or slow the disease.
Boston, MassachusettsAges 18 years+ - NCT06208826RecruitingPhase 2
Immunotherapy maintenance after surgery for head and neck cancer
This trial looks at whether continuing immunotherapy can help keep cancer from coming back in people with head and neck cancer who had a good response to chemo-immunotherapy before surgery. You would have already had surgery, and now the study tests a maintenance treatment to strengthen your immune system's fight against any remaining cancer cells.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06211335RecruitingPhase 1
Losartan, pembrolizumab and radiation for advanced head & neck cancer
This trial tests a combination of three treatments—a blood pressure drug (losartan), an immunotherapy (pembrolizumab), and targeted radiation—for people with head and neck cancer that has come back, spread to a few spots, or is not responding to other treatments. The goal is to see if this mix can shrink tumors and help patients who have few options left.
Sacramento, CaliforniaAges 18 years+ - NCT05945875RecruitingPhase 1
Dual scans to find head and neck cancer spread
This early-stage study tests two different imaging (scanning) methods to better detect head and neck cancer. Your results from the scans may help doctors see where disease is before standard surgery to remove lymph nodes in the neck.
Nashville, TennesseeAges 19 years+ - NCT06192771Recruiting
Swallowing and speech therapy after tongue cancer surgery
This trial tests whether starting speech and swallowing therapy early after surgery helps people with tongue cancer recover their ability to eat and talk. It is for patients having part of their tongue removed and rebuilt with a tissue flap.
Toronto, OntarioAges 18 years+ - NCT06184880Recruiting
Physical activity program for sedentary cancer patients
This trial tests whether a remote physical activity program can help reduce time spent sitting for people with new upper aerodigestive tract cancer. If you qualify, you may be able to take part in exercise sessions from home.
ValenceAges 18 years+ - NCT06161545RecruitingPhase 2
Immunotherapy before surgery for head and neck cancer
This trial tests a combination of two immunotherapy drugs (pembrolizumab and N-803) with or without special immune cells (PD-L1 t-haNK cells) before surgery for head and neck cancer. The goal is to see if this treatment can shrink the cancer or improve the outcome after surgery.
Bethesda, MarylandAges 18–120 - NCT06172478RecruitingPhase 2
HER3-DXd for advanced solid tumors after prior treatment
This trial tests a new targeted drug called HER3-DXd for people with several types of advanced solid tumors that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver chemotherapy directly to cancer cells that have a protein called HER3 on their surface.
Duarte, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for head and neck cancer?
- Yes. Clin2 currently lists 618 recruiting head and neck cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.