Clinical trials
Head and Neck clinical trials
Below are recruiting head and neck clinical trials, each written for real people, not researchers. We’re tracking 691 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03394417Recruiting
StrataXRT skin gel to prevent rash during head and neck radiation
This trial tests whether a medicated skin gel (StrataXRT) can better prevent painful skin rash (“acute dermatitis”) in people with head and neck cancer who receive chemotherapy and radiation at the same time. If you’re eligible, you may get the study skin product and help doctors find a safer, more comfortable way to protect the skin during treatment.
SingaporeAges 21–80 - NCT07318220Recruiting
Exercise and nutrition program before head and neck cancer treatment
This study tests a program that helps patients prepare for radiation or chemoradiation treatment for head and neck cancer. The program includes exercise and diet guidance to improve health before treatment starts.
Miami, FloridaAges 18–80 - NCT03481647Recruiting
Oral care program for people getting head and neck radiation
This trial tests an oral (mouth) care program for people with head and neck cancer who are about to start full-dose, curative radiation. It may help protect your mouth and salivary glands during treatment.
GothenburgAges 18–80 - NCT06465628Recruiting
Acupressure for dry mouth after head and neck cancer treatment
This trial tests if acupressure can help with dry mouth caused by radiation therapy for head and neck cancer. If you have dry mouth after treatment and can speak Cantonese or Mandarin, you may be able to join.
Hong Kong, Hong KongAges 18 years+ - NCT06148077Recruiting
Manual therapy for head and neck cancer survivors with jaw or shoulder issues
This study tests whether manual therapy (hands-on treatment) can improve mouth opening, swallowing, and movement in people who had head and neck cancer surgery or radiation. It may help if you have jaw stiffness, pain, or shoulder problems after treatment.
Temuco, CautinAges 18 years+ - NCT06959108RecruitingPhase 2
Comparing two treatments for head and neck cancer before chemoradiation
This trial tests two different drug combos—one using an EGFR-targeted therapy alone, the other adding an immunotherapy—before standard chemoradiation for locally advanced head and neck cancer. The goal is to see which approach works better without prior treatment.
VillejuifAges 18–75 - NCT06856213RecruitingPhase 2
Cetuximab with or without weekly paclitaxel for head and neck cancer
This study tests whether adding the chemotherapy drug paclitaxel (Taxol) to the targeted therapy cetuximab (Erbitux) is more effective than cetuximab alone for head and neck cancer that has progressed after initial immunotherapy and chemotherapy. Researchers want to see if the combination can help shrink tumors or slow the disease.
Santiago de Compostela, A CoruñaAges 18 years+ - NCT05738603Recruiting
Predicting low blood pressure during head and neck flap surgery
This study looks at a way to predict low blood pressure during head and neck free flap surgery (when tissue is moved from one place to another). If successful, it may help the surgical team prevent complications by preparing earlier.
Poznan, PoznańAges 18 years+ - NCT06676592Recruiting
3D technology to guide head and neck surgery
This trial tests whether 3D imaging can help surgeons better plan and perform head and neck operations. If you're scheduled for head and neck surgery and standard scans, this study may improve your surgical precision.
Basking Ridge, New JerseyAges 18 years+ - NCT06641791RecruitingPhase 3
Comparing two radiation approaches for advanced head and neck cancer
This trial compares two types of radiation therapy to relieve symptoms from advanced head and neck cancer that cannot be cured. One is a shorter, more precise treatment (SBRT), and the other is standard radiation. The goal is to see which better improves quality of life and reduces side effects.
Calgary, AlbertaAges 18 years+ - NCT06593639Recruiting
Prehabilitation for head and neck cancer patients
This study tests a prehabilitation program (exercise and nutrition support) to see if it helps patients with head and neck cancer who are about to start curative treatment. It aims to improve your strength and recovery before and during cancer therapy.
Naples, ItalyAges 18 years+ - NCT06385132Recruiting
Studying mental health in brain and head/neck cancer
This study looks at the emotional and mental health of people with glioblastoma (a type of brain tumor) or head and neck cancer who are getting a long course of radiation therapy. The goal is to understand how they are feeling so doctors can provide better support.
RomaAges 18–75 - NCT06297902Recruiting
PET-guided Radiation for Head and Neck Cancer
This trial tests a new way to give radiation therapy for head and neck cancer. By using a special PET scan to guide where higher radiation doses are given, doctors hope to improve treatment while reducing side effects. It is for people whose cancer is not early-stage and who will receive standard radiation therapy.
BergenAges 18 years+ - NCT06124508Recruiting
Lung cancer screening awareness for Hispanic head and neck cancer survivors
This study aims to increase awareness and use of lung cancer screening among Hispanic/Latinx individuals who have survived head and neck cancer. You may be able to join if you are a long-term survivor, have a significant smoking history, and haven't had a lung scan recently.
Miami, FloridaAges 18–80 - NCT05919290Recruiting
Study MRI imaging markers in head and neck cancer
This study uses repeat MRI scans to look for imaging “markers” that may help doctors better understand head and neck squamous cell cancer. It may be most relevant if you are planning curative surgery and/or (chemo)radiotherapy and can safely undergo MRI more than once.
Toronto, OntarioAges 18 years+ - NCT05542706Recruiting
Extra support for caregivers after head and neck cancer surgery
This trial tests whether adding “paramedical” support (extra practical health help) for caregivers improves care after a patient has curative surgery for certain head and neck cancers. It’s designed for patient–caregiver pairs and may help families during the stressful period around surgery and follow-up treatment.
RouenAges 18–85 - NCT05376553Enrolling by invitationPhase 1
Test cemiplimab plus chemo before treatment for head and neck cancer
This Phase 1 trial tests cemiplimab (an immune system medicine) given with “induction” chemotherapy before the main treatment for locally advanced squamous cell head and neck cancer. It’s designed to see how well this treatment is tolerated and to learn about immune responses that may help future patients.
New York, New YorkAges 18 years+ - NCT03908684Recruiting
Ultrasound tests to predict early response to prostate and head/neck radiation
This study uses special ultrasound imaging to look for early signs of how well radiation treatment is working in prostate, rectum, and head/neck cancers. It may help doctors spot response sooner and adjust care earlier if needed.
Toronto, OntarioAges Any age - NCT07417605Recruiting
Using a new PET scan to tell cancer from inflammation after radiation
This study uses a special PET scan to tell the difference between leftover cancer and inflammation caused by radiation in people treated for head and neck cancer. It may help doctors know if more treatment is needed.
BrestAges 18 years+ - NCT06265285RecruitingPhase 2
Nivolumab at home vs. clinic for cancer treatment
This study compares giving the immunotherapy drug nivolumab as a shot under the skin at home versus in the clinic. It is for people with certain cancers who are already taking or starting nivolumab.
Jacksonville, FloridaAges 18 years+ - NCT07405086RecruitingPhase 4
Morning versus afternoon immunotherapy for advanced cancer
This trial tests whether getting your immunotherapy infusion in the morning or in the afternoon makes any difference in how well it works. If you have certain types of advanced cancer and are about to start a standard FDA-approved immunotherapy, this study may help you and others by finding the best time of day for treatment.
Portland, OregonAges 18 years+ - NCT05136196RecruitingPhase 2
Cabozantinib plus nivolumab for advanced melanoma or head-neck cancer
This trial tests whether combining two immunotherapy medicines—cabozantinib and nivolumab—can shrink advanced melanoma or certain head-and-neck squamous cell cancers. It is mainly for people whose cancer has grown after prior PD-1 treatment.
Phoenix, ArizonaAges 18 years+ - NCT07744126RecruitingPhase 2
Combination drug therapy for head and neck cancer that has spread
This trial tests a new combination of two drugs (telisotuzumab adizutecan and pembrolizumab) for people with head and neck cancer that has come back or spread and cannot be cured with local treatments. The goal is to see if this combination can help control the cancer and to find the best dose.
Duarte, CaliforniaAges 18 years+ - NCT06769698RecruitingPhase 2
Testing fianlimab with cemiplimab for head and neck cancer
This study compares a new combination of two drugs (fianlimab and cemiplimab) against cemiplimab alone for people with head and neck cancer that has returned or spread. It aims to see if the combination works better.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for head and neck?
- Yes. Clin2 currently lists 691 recruiting head and neck studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.