Clinical trials
Head and Neck clinical trials
Below are recruiting head and neck clinical trials, each written for real people, not researchers. We’re tracking 691 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06607406Recruiting
Timing of radiation after surgery for head and neck cancer
This study tests whether starting radiation therapy more than 6 weeks (but within 16 weeks) after surgery is safe and effective for people with certain high-risk head and neck cancers. It could help those who had to delay radiation for recovery or other reasons.
Charlotte, North CarolinaAges 18 years+ - NCT05758389RecruitingPhase 2
Immunotherapy plus chemo for locally advanced head and neck cancer
This Phase 2 study tests whether tislelizumab (an immunotherapy) combined with chemotherapy works better for locally advanced head and neck squamous cell cancer. It aims to improve cancer control when the tumor is large and has not spread to distant organs.
Nanjing, JiangsuAges 18–75 - NCT06356272Recruiting
Oropharynx cancer biomarker study
This study looks at certain markers (called p16 and HPV) in tumor samples to better understand oropharynx cancer. It may help doctors learn more about the disease and guide future treatments.
Rochester, MinnesotaAges 18 years+ - NCT06344208Recruiting
Predicting side effects in older adults with head and neck cancer
This trial studies how to predict side effects (toxicity) in older adults (70+) with advanced head and neck cancer. It tests standard treatments like radiation, chemoradiation, or radiation with cetuximab and aims to help doctors tailor care to reduce harm.
Milan, MilanAges 70–99 - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05671458Recruiting
Imaging guidance during head and neck tumor surgery plus radiation
This trial tests whether advanced imaging used during surgery can better guide where surgeons remove head-and-neck tumors. It also studies how this approach works alongside planned postoperative radiation therapy, which may be needed for more advanced tumors.
HeidelbergAges 18 years+ - NCT05432297Recruiting
Exercise program for people getting treatment for head and neck cancer
This trial tests whether a preventive, structured physical activity program can help people during and around curative treatment for head and neck cancers. It aims to see if exercise is safe and beneficial for strength, function, and well-being during radio(±chemo) therapy.
GothenburgAges 18 years+ - NCT00230308Recruiting
Study of new genes in head and neck cancer surgery tissue
This study looks at tissue from people having surgery for head and neck cancer at Stanford University. Researchers want to identify new proteins and genes that may help explain the cancer and guide future treatments.
Stanford, CaliforniaAges 18 years+ - NCT03483337Recruiting
MRI scan tests new markers for head and neck cancers
This trial tests special MRI scans to find warning signs of cancer that has returned or spread in the head and neck area. It may help doctors see these changes more clearly, which could improve treatment planning.
New York, New YorkAges 18 years+ - NCT00200486Recruiting
Molecular testing of head and neck tumors
This study looks at head and neck tumors using molecular and genetic tests. It may help doctors learn more about what drives different tumors and how they might respond to treatment, using biopsy or stored tumor tissue.
The Bronx, New YorkAges Any age - NCT07766226Recruiting
Online support group for head and neck cancer patients
This study tests whether an online support group can help people with head and neck cancer feel better during and after their radiation treatment. You would participate in a shared online community and complete questionnaires about your well-being.
Chengdu, SichuanAges 18–75 - NCT07622381Recruiting
Specialist Nurse Care for Head and Neck Cancer Surgery
This trial tests whether extra support from specially trained nurses helps patients recover better after head and neck cancer surgery. The study focuses on improving care, managing side effects, and supporting your overall recovery.
TianjinAges 18–70 - NCT06642324Recruiting
HPV and genetics in head and neck cancer study
This study looks at how HPV infection and genetic changes relate to head and neck squamous cell carcinoma. If you have this type of cancer, joining could help doctors learn more about the disease and improve future treatments.
Dhaka, Dhaka DivisionAges 18 years+ - NCT05172245RecruitingPhase 1
Testing a new drug added to chemoradiation for head and neck cancer
This study tests whether adding a new targeted drug called ipatasertib to standard chemoradiation can improve treatment for people with locally advanced head and neck cancer. Ipatasertib may help block a protein that helps cancer grow, possibly making the standard therapy more effective.
Tampa, FloridaAges 18 years+ - NCT05707078Recruiting
PET/CT follow-up for head and neck cancer
This study uses a PET/CT scan (a special scan that can look for signs of cancer activity) after curative treatment for head and neck squamous cell cancer. It aims to help check how well prior treatment is working and whether cancer may come back.
Copenhagen, CopenhagenAges 18 years+ - NCT06636734RecruitingPhase 2
Lovastatin plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding lovastatin (a cholesterol-lowering drug) to pembrolizumab (an immunotherapy) works better than pembrolizumab alone for head and neck cancer that has come back or spread. It's for people who haven't had immunotherapy before and aren't already on a statin.
Atlanta, GeorgiaAges 18 years+ - NCT04429542RecruitingPhase 1
Test of an EGFR-targeting drug for advanced solid cancers
This Phase 1 study tests the safety of BCA101 (an EGFR-targeting treatment) alone or combined with pembrolizumab. It may help people with certain EGFR-driven advanced cancers, depending on the tumor type, prior treatments, and required biopsy testing.
La Jolla, CaliforniaAges 18 years+ - NCT02435576Recruiting
Standard follow-up program for head and neck cancer patients
This trial sets up a standard schedule for follow-up visits for people receiving curative (aimed at cure) or after-surgery radiotherapy for head and neck cancer. It may help you stay on track with regular check-ins and early management of side effects or signs of recurrence.
GroningenAges 18 years+ - NCT03914378Recruiting
Study how radiation and cisplatin affect hearing in head and neck cancer
This study looks at how radiotherapy, and possibly cisplatin chemotherapy, affect hearing in people treated for head and neck cancer. It may help doctors better predict hearing side effects and plan hearing monitoring or prevention.
ManchesterAges 18 years+ - NCT06472570Recruiting
Targeted radiation for head and neck tumors
This trial tests a precise type of radiation called stereotactic radiosurgery for people with head or neck tumors. It may be an option for those who need radiation or chemoradiation as their main treatment or after surgery.
Gliwice, GliwicwAges 18–80 - NCT07801235Recruiting
Radiation therapy with or without chemotherapy for head and neck cancer
This trial compares two treatments for certain head and neck cancers: radiation therapy alone given more often (hyperfractionated) versus radiation combined with chemotherapy. The goal is to see if one approach is better at controlling the cancer while limiting side effects.
AmmanAges 18–75 - NCT07795294Recruiting
Swallowing exercises for head and neck cancer patients
This trial tests a swallowing exercise program for people getting chemoradiotherapy for head and neck cancer. The goal is to help you swallow better and reduce side effects from treatment.
CairoAges 20–60 - NCT06248996RecruitingPhase 3
Testing a stronger radiation schedule for large head and neck cancers
This trial tests whether giving a slightly different schedule of radiation (more frequent, smaller doses) can improve treatment for people with large head and neck cancers. It is for patients who are getting radiation as their main treatment, sometimes with chemotherapy as well.
GävleAges 18–100
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Common questions
- Are there clinical trials for head and neck?
- Yes. Clin2 currently lists 691 recruiting head and neck studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.