Clinical trials
Head Cancer clinical trials
Below are recruiting head cancer clinical trials, each written for real people, not researchers. We’re tracking 523 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05988060Recruiting
Exercise support during radiation for head and neck cancer
This study tests whether a structured exercise program during radiation therapy helps people with head and neck cancer feel better and stay stronger. You will do supervised exercises while you receive your usual cancer treatment.
Tilburg, North BrabantAges 18 years+ - NCT06344208Recruiting
Predicting side effects in older adults with head and neck cancer
This trial studies how to predict side effects (toxicity) in older adults (70+) with advanced head and neck cancer. It tests standard treatments like radiation, chemoradiation, or radiation with cetuximab and aims to help doctors tailor care to reduce harm.
Milan, MilanAges 70–99 - NCT06706973Recruiting
Epigenetic study for new head and neck cancer treatments
This trial studies the role of epigenetic marks in head and neck cancer to improve diagnosis and treatment. If you have been newly diagnosed with head and neck squamous cell carcinoma and have not yet received treatment, you may be eligible to participate.
Milan, MIAges 18 years+ - NCT06876844RecruitingPhase 2
Surufatinib plus Envolizumab for advanced head and neck cancer
This study tests a new combination of two drugs (Surufatinib and Envolizumab) as a second treatment option for people with head and neck cancer that has returned or spread. It's for patients whose first treatment (usually chemo or immunotherapy) stopped working within 6 months.
ShanghaiAges 18–75 - NCT06952868RecruitingPhase 2
BNCT for recurrent head and neck cancer
This trial tests a special type of radiation therapy called BNCT (boron neutron capture therapy) for head and neck cancers that have come back and cannot be removed by surgery. It may be an option for patients who have already had radiation and cannot receive standard chemotherapy.
TaichungAges 18–80 - NCT07065630RecruitingPhase 2
New immunotherapy for HPV-negative head and neck cancer
This trial tests a new immunotherapy drug called volrustomig for people with advanced head and neck cancer that is not caused by HPV. The goal is to see if giving this treatment based on how the cancer responds can help shrink tumors or stop them from growing.
Chicago, IllinoisAges 18 years+ - NCT00230308Recruiting
Study of new genes in head and neck cancer surgery tissue
This study looks at tissue from people having surgery for head and neck cancer at Stanford University. Researchers want to identify new proteins and genes that may help explain the cancer and guide future treatments.
Stanford, CaliforniaAges 18 years+ - NCT07675421Recruiting
HMB supplement for head and neck cancer surgery
This trial tests whether taking HMB (a supplement that may help reduce inflammation) can improve recovery and outcomes in people with head and neck cancer who are scheduled for surgery to remove their tumor.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT07622914Recruiting
Dietary fiber and muscle health in head and neck cancer
This study tests whether eating more fiber can help prevent muscle loss in people newly diagnosed with head and neck cancer. Researchers will track your nutrition and muscle strength over time to see if dietary fiber makes a difference.
Oklahoma City, OklahomaAges 18 years+ - NCT06572423Recruiting
Personalized focused radiation for head and neck cancer
This trial tests a personalized, very precise radiation treatment (called PULS-Pal) for head and neck cancer that cannot be cured with standard therapies. It aims to shrink tumors and help with symptoms while limiting side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT05811936Recruiting
SNAP support tool for head and neck cancer survivors and caregivers
This trial tests a “SNAP” support tool designed for people who have head and neck cancer and the caregiver who helps them. It aims to improve support and coping during and after cancer treatment by involving both the survivor and their main support person.
Charleston, South CarolinaAges 18 years+ - NCT06544720RecruitingPhase 1
SCG142 TCR-T cell therapy for HPV-related cancers
This trial tests a new treatment called SCG142 TCR-T cells for cancers caused by HPV. The therapy uses your own immune cells to fight the tumor. It may help if other treatments haven't worked or are not available.
Qingdao, ShandongAges 18 years+ - NCT04172753Recruiting
Online MRI-guided radiation therapy on a 1.5T machine
This trial checks whether it’s practical and safe to deliver radiation treatment using real-time MRI guidance, with the process supported online. It may help patients whose doctors recommend radiation by testing a modern way to plan and deliver treatment more precisely.
Tübingen, Baden-WurttembergAges 18 years+ - NCT04354064Recruiting
Blood DNA test to see early treatment response in solid tumors
This study looks at circulating tumor DNA, which is tiny bits of DNA found in blood, to help assess how solid tumors are responding early. It uses blood samples from healthy adults who are willing to donate.
St Louis, MissouriAges 18 years+ - NCT06778863RecruitingPhase 1
A study of CLSP-1025 for adults with certain solid tumors
This trial tests a new drug called CLSP-1025 for people with advanced solid tumors that have a specific change in the p53 gene (R175H). The drug targets this change to help fight the cancer.
Scottsdale, ArizonaAges 18 years+ - NCT06869473RecruitingPhase 2
Cetuximab, chemo, and avelumab for head and neck cancer
This trial tests a combination of targeted therapy (cetuximab) and immunotherapy (avelumab) plus chemotherapy as a first treatment for people with head and neck cancer that has come back or spread. The goal is to see if adding these medicines helps control the cancer longer.
Cagliari, CAGLIARIAges 18 years+ - NCT06681233Recruiting
Cone-beam CT for guiding radiation therapy in cancer patients
This study tests whether a special X-ray called cone-beam CT (CBCT) can help guide radiation therapy more precisely for different types of cancer. If you are already scheduled for radiation and use CBCT as part of your care, you may be able to join.
Columbus, OhioAges 18 years+ - NCT06641791RecruitingPhase 3
Comparing two radiation approaches for advanced head and neck cancer
This trial compares two types of radiation therapy to relieve symptoms from advanced head and neck cancer that cannot be cured. One is a shorter, more precise treatment (SBRT), and the other is standard radiation. The goal is to see which better improves quality of life and reduces side effects.
Calgary, AlbertaAges 18 years+ - NCT07510321Recruiting
A study of FL-261 imaging for cancer diagnosis
This trial tests a new imaging agent called FL-261 to help doctors see and stage cancers more clearly. If you have a known or suspected cancer like lung, colon, or head and neck cancer, this study may improve how your cancer is evaluated.
Wuhan, HubeiAges 18 years+ - NCT07726407Recruiting
Surface-guided radiation for head and neck cancer
This trial tests a special camera system (SGRT) to help you stay still during head and neck radiation. It may make treatment more accurate and comfortable by using your own breathing to guide positioning.
Guangzhou, GuangdongAges 18–75 - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT03394417Recruiting
StrataXRT skin gel to prevent rash during head and neck radiation
This trial tests whether a medicated skin gel (StrataXRT) can better prevent painful skin rash (“acute dermatitis”) in people with head and neck cancer who receive chemotherapy and radiation at the same time. If you’re eligible, you may get the study skin product and help doctors find a safer, more comfortable way to protect the skin during treatment.
SingaporeAges 21–80 - NCT03481647Recruiting
Oral care program for people getting head and neck radiation
This trial tests an oral (mouth) care program for people with head and neck cancer who are about to start full-dose, curative radiation. It may help protect your mouth and salivary glands during treatment.
GothenburgAges 18–80 - NCT06148077Recruiting
Manual therapy for head and neck cancer survivors with jaw or shoulder issues
This study tests whether manual therapy (hands-on treatment) can improve mouth opening, swallowing, and movement in people who had head and neck cancer surgery or radiation. It may help if you have jaw stiffness, pain, or shoulder problems after treatment.
Temuco, CautinAges 18 years+
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Common questions
- Are there clinical trials for head cancer?
- Yes. Clin2 currently lists 523 recruiting head cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Head and Neck Cancer
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Head and Neck Squamous Cell Cancer
- Head and Neck Cancer (H&N)
- Head and Neck Cancer Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Gastric Cancer, Gastroesophageal Junction Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.