Clinical trials
Head Cancer clinical trials
Below are recruiting head cancer clinical trials, each written for real people, not researchers. We’re tracking 527 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03394417Recruiting
StrataXRT skin gel to prevent rash during head and neck radiation
This trial tests whether a medicated skin gel (StrataXRT) can better prevent painful skin rash (“acute dermatitis”) in people with head and neck cancer who receive chemotherapy and radiation at the same time. If you’re eligible, you may get the study skin product and help doctors find a safer, more comfortable way to protect the skin during treatment.
SingaporeAges 21–80 - NCT07318220Recruiting
Exercise and nutrition program before head and neck cancer treatment
This study tests a program that helps patients prepare for radiation or chemoradiation treatment for head and neck cancer. The program includes exercise and diet guidance to improve health before treatment starts.
Miami, FloridaAges 18–80 - NCT03481647Recruiting
Oral care program for people getting head and neck radiation
This trial tests an oral (mouth) care program for people with head and neck cancer who are about to start full-dose, curative radiation. It may help protect your mouth and salivary glands during treatment.
GothenburgAges 18–80 - NCT06465628Recruiting
Acupressure for dry mouth after head and neck cancer treatment
This trial tests if acupressure can help with dry mouth caused by radiation therapy for head and neck cancer. If you have dry mouth after treatment and can speak Cantonese or Mandarin, you may be able to join.
Hong Kong, Hong KongAges 18 years+ - NCT06148077Recruiting
Manual therapy for head and neck cancer survivors with jaw or shoulder issues
This study tests whether manual therapy (hands-on treatment) can improve mouth opening, swallowing, and movement in people who had head and neck cancer surgery or radiation. It may help if you have jaw stiffness, pain, or shoulder problems after treatment.
Temuco, CautinAges 18 years+ - NCT06593639Recruiting
Prehabilitation for head and neck cancer patients
This study tests a prehabilitation program (exercise and nutrition support) to see if it helps patients with head and neck cancer who are about to start curative treatment. It aims to improve your strength and recovery before and during cancer therapy.
Naples, ItalyAges 18 years+ - NCT06385132Recruiting
Studying mental health in brain and head/neck cancer
This study looks at the emotional and mental health of people with glioblastoma (a type of brain tumor) or head and neck cancer who are getting a long course of radiation therapy. The goal is to understand how they are feeling so doctors can provide better support.
RomaAges 18–75 - NCT06297902Recruiting
PET-guided Radiation for Head and Neck Cancer
This trial tests a new way to give radiation therapy for head and neck cancer. By using a special PET scan to guide where higher radiation doses are given, doctors hope to improve treatment while reducing side effects. It is for people whose cancer is not early-stage and who will receive standard radiation therapy.
BergenAges 18 years+ - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT07108517Recruiting
Post-traumatic growth program for cancer survivors in Greece
This trial tests a guided program to help people with breast, colorectal, or head and neck cancer find personal growth after finishing chemotherapy. It is for those who have completed their planned treatment within the last 5 years and are not currently in other psychological care.
ThessalonikiAges 18–80 - NCT05542706Recruiting
Extra support for caregivers after head and neck cancer surgery
This trial tests whether adding “paramedical” support (extra practical health help) for caregivers improves care after a patient has curative surgery for certain head and neck cancers. It’s designed for patient–caregiver pairs and may help families during the stressful period around surgery and follow-up treatment.
RouenAges 18–85 - NCT07348887Recruiting
Daily adaptive radiotherapy for head and neck cancer to spare salivary glands
This trial tests a new daily adaptive radiotherapy technique that aims to spare the submandibular salivary glands during head and neck cancer treatment. It may help reduce dry mouth after radiation.
Toronto, OntarioAges 18 years+ - NCT05946577Recruiting
Links tinnitus and hearing changes after head and neck cancer treatment
This study looks at how tinnitus (ringing in the ears) and hearing problems may develop after radiotherapy alone or with certain chemotherapy for high-risk head and neck cancer. The goal is to better understand who is more likely to experience these side effects.
ParisAges 18 years+ - NCT04273061RecruitingPhase 2
Atezolizumab for tumors that look sensitive on DNA/RNA testing
This Phase 2 study tests atezolizumab, an immunotherapy drug, in people with advanced, incurable solid tumors whose tumor DNA/RNA suggests they may respond. The goal is to see if the treatment works better for patients selected by these lab results.
Vancouver, British ColumbiaAges 18 years+ - NCT07101432RecruitingPhase 1
Radiation plus engineered NK cells for advanced head and neck cancer
This early-phase trial tests a new type of immune cell therapy combined with radiation for advanced head and neck cancer. The cells are engineered to target the TROP2 marker on cancer cells and are given after a short course of radiation to help them work better.
Houston, TexasAges 18 years+ - NCT05874492Recruiting
Spa therapy for radiation-related skin fibrosis after cancer
This trial tests whether a spa therapy program can improve “fibrosis,” or stiffened/scarred tissue and related skin problems, after radiotherapy for breast cancer or upper head/neck cancers. It aims to see if treatment can improve quality of life for people who still have moderate-to-worse symptoms months after radiation.
BordeauxAges 18 years+ - NCT05983432RecruitingPhase 1
Study of BL-B01D1 for advanced lung and other solid tumors
This trial tests an experimental drug called BL-B01D1 for people with several types of advanced solid tumors, especially non-small cell lung cancer and breast cancer. It's designed for those whose cancer has continued to grow after standard treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT03958240Recruiting
Study how cancers trigger the immune system
This study looks at what makes some cancers more “noticeable” to the immune system. It may help researchers design better future immunotherapy by collecting information (often including blood samples) from people with different cancers.
ToulouseAges 18 years+ - NCT06041555Recruiting
MRI-guided radiotherapy study for five cancer types
This study collects MRI scans and treatment data from patients getting MRI-guided radiotherapy for certain cancers. It aims to improve radiation treatment planning using imaging and biological information.
LyonAges 18 years+ - NCT07218003Enrolling by invitationPhase 1
Study of RNDO-564 alone or with pembrolizumab for bladder cancer
This trial tests an experimental drug, RNDO-564, either by itself or combined with another drug (pembrolizumab), for people with advanced bladder cancer or other solid tumors that have stopped responding to standard treatments. The goal is to see if it can shrink tumors or slow cancer growth.
San Francisco, CaliforniaAges 18 years+ - NCT07179315RecruitingPhase 2
Immunotherapy Study for HPV-Positive Head and Neck Cancer
This trial compares two different immunotherapy approaches for people with HPV-positive oropharyngeal cancer who have completed initial treatment like surgery, radiation, or chemotherapy. The goal is to see which option works better to keep the cancer from coming back, and eligibility is determined by a special blood test that detects HPV DNA.
Chicago, IllinoisAges 18 years+ - NCT04915183RecruitingPhase 2
Atorvastatin to help prevent cisplatin-related hearing loss
This Phase 2 trial tests whether a cholesterol medicine called atorvastatin can protect hearing in people with head and neck cancer receiving cisplatin plus radiation. If it works, it may reduce the chance or severity of treatment-related hearing damage.
Atlanta, GeorgiaAges 18–100 - NCT06444776Recruiting
Taste and saliva changes during radiotherapy for head & neck cancer
This study looks at how radiation therapy for head and neck cancer changes your sense of taste and saliva. It aims to better understand and manage these side effects.
Aarau, Canton of AargauAges 18 years+ - NCT01985984Recruiting
Predicting outcomes after head and neck radiotherapy
This study looks at how outcomes may be predicted for people with head and neck cancer who receive radiotherapy. It may help doctors better estimate results and tailor follow-up care.
MaastrichtAges 18 years+
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Common questions
- Are there clinical trials for head cancer?
- Yes. Clin2 currently lists 527 recruiting head cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Head and Neck Cancer
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Head and Neck Squamous Cell Cancer
- Head and Neck Cancer (H&N)
- Head and Neck Cancer Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Gastric Cancer, Gastroesophageal Junction Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.