Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07159750Recruiting
Study on new migraine drugs in real life
This study tracks how well new migraine medications (like Aimovig, Emgality, Ajovy, Vyepti, Qulipta, and Nurtec) work in everyday use. It may help you and your doctor understand if these treatments are a good option for your migraines.
Miami, FloridaAges 18 years+ - NCT07166536Recruiting
Study on mental imagery and symptom worsening after concussion
This trial tests whether mental imagery tasks can trigger or worsen headaches and dizziness in people with long-lasting symptoms after a mild traumatic brain injury or concussion. If you still have headaches or dizziness more than 3 months after your injury, this study may help understand how your brain reacts to mental exercises.
Tel AvivAges 18–70 - NCT07223008Recruiting
Bilateral artery embolization for chronic migraine
This trial tests a procedure called bilateral middle meningeal artery embolization to see if it reduces chronic migraine symptoms in people who haven't found relief from other treatments. It's for those with frequent, disabling migraines that affect both sides of the head.
Baltimore, MarylandAges 18–80 - NCT06459635Recruiting
Migraine attack prediction study using smartphone tracking
This study uses a smartphone app or device to track your body signals and predict when a migraine attack is about to start. It is designed for people with frequent (10–14 days per month) migraines.
Madrid, MadridAges 18–65 - NCT06459648Recruiting
Can anti-CGRP antibodies prevent chronic migraine?
This study tests a new treatment (anti-CGRP antibodies) to prevent migraine attacks from becoming chronic. It looks at whether we can predict who will respond best, aiming to find better long-term control for people with frequent or chronic migraine.
Zaragoza, AragonAges 18–65 - NCT07294118RecruitingPhase 2
Lidocaine and steroids for pain after brain bleed
This trial tests whether giving a numbing medicine (lidocaine) and steroids into the artery that covers the brain can help reduce pain after a brain bleed. It may be an option for people with a specific type of bleeding who have not had certain brain surgeries or procedures.
Galveston, TexasAges 18–100 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07347067Recruiting
Trigger point injections for chronic migraine
This study tests if injecting medication into specific painful spots in your muscles (called trigger points) can help reduce chronic migraine pain. It may be an option if you've tried other treatments but still have significant pain.
Beijing, Beijing MunicipalityAges 18–65 - NCT07404956Recruiting
Comparing surgical and N95 masks for operating room nurses
This study checks how wearing a surgical mask or an N95 mask affects the air quality during surgery (called surgical smoke). It is for operating room nurses who work with surgical smoke regularly.
Bartın, BartınAges 18 years+ - NCT07419607Recruiting
Group therapy with exercise for teens with migraine
This study tests a group therapy program for teens with migraine. The program combines physical activity, muscle relaxation, and education about migraines. It aims to help teens manage their headaches better.
Innsbruck, TyrolAges 13–17 - NCT07440667Recruiting
Fluid amounts during planned C-section and recovery
This trial compares giving less fluid versus more fluid during planned C-section surgery to see which approach leads to better recovery afterward.
Niğde, MerkezAges 18–45 - NCT07454798Recruiting
Virtual reality neurofeedback for teens with migraine
This study tests whether using virtual reality neurofeedback can help teens with migraine. You would wear a VR headset and learn to control your brain's activity to reduce headache frequency.
Kansas City, MissouriAges 10–16 - NCT07476053Recruiting
How light exposure affects migraine and sleep
This study looks at how office lighting and sleep quality affect migraine. You'll track your headaches and light exposure. The goal is to find ways to improve sleep and reduce migraine attacks.
Tempe, ArizonaAges 18 years+ - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07555873Recruiting
Osteopathic treatment versus physical therapy for neck and head dysfunction
This study compares two hands-on treatment approaches—osteopathic manipulation and physiotherapy—for chronic neck pain, headaches, and dizziness caused by cervical dysfunction. If you qualify, you'll receive one of these treatments and help researchers understand which works better.
Pristina, PejtonAges 18–65 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75 - NCT07629141Recruiting
Muscle Position and Dry Needling for Neck Pain
This study tests whether the position of your neck muscle affects how well dry needling (inserting thin needles into tight muscle knots) relieves chronic neck pain. Dry needling may help reduce pain by relaxing tense muscles.
Alcalá de Henares, MadridAges 18–80 - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Ridgeland, MississippiAges 12 years+ - NCT06999304Enrolling by invitation
Pilot TMS for ongoing mild concussion symptoms
This study tests whether a type of brain stimulation called TMS can help people with ongoing symptoms after a mild concussion. If you have had concussion symptoms for at least a month but less than a year, you may be able to join.
Saint Paul, MinnesotaAges 18–65 - NCT06834022Enrolling by invitation
Comparing acupuncture and brain stimulation for migraine
This study compares two non-drug treatments—acupuncture and a gentle form of brain stimulation (tDCS)—to see which one helps reduce migraine headaches better. It's for people who have at least 4 migraine days per month and have never tried acupuncture before.
Ljubljana, LjubljanaAges 18–65 - NCT06581185Enrolling by invitation
Long-term headache outcomes in childhood pseudotumor cerebri
This trial is studying how headaches from pseudotumor cerebri (a condition of increased pressure around the brain) change over 10 years in people who were diagnosed as children. It might help doctors understand the long-term effects of this condition.
HaifaAges Any age
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 165 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.