Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06077838Recruiting
RELAXaHEAD app test for migraine relief
This study tests a smartphone app called RELAXaHEAD that teaches relaxation techniques to help people with migraine. If you have 4–29 headache days per month and haven't tried relaxation therapy for headaches recently, this app might help reduce your symptoms.
New York, New YorkAges 16–80 - NCT06225817Recruiting
Can a placebo help with chronic jaw pain and sleep?
This study is testing whether a placebo (a pill with no medication) can help improve sleep and reduce pain for people with long-term jaw or face pain. Researchers want to see if just expecting relief can change how your body handles pain.
Baltimore, MarylandAges 18–88 - NCT06229834Recruiting
Chiropractic care for episodic migraine
This study tests whether chiropractic adjustments (spinal manipulation) can help reduce the number of migraine days you have each month. You will be randomly assigned to one of two groups: one group gets chiropractic care plus usual care, the other gets a sham (fake) treatment plus usual care, so researchers can see if the real adjustments work better.
Boston, MassachusettsAges 18–65 - NCT06260072RecruitingPhase 2
Magnesium and Riboflavin for Post-Concussion Headaches
This trial tests if taking magnesium and riboflavin (vitamin B2) can help reduce headaches after a concussion. It is for University of Virginia students who have had a concussion within the past 3 days and can swallow pills.
Charlottesville, VirginiaAges 18–40 - NCT06470958Recruiting
Brain scans in women with period-related migraine
This study uses brain scans (MRI) to compare the brain activity of women who have migraine attacks linked to their period with women who don't have migraine. It aims to find brain features that make some women more prone to menstrually-related migraine.
Glostrup MunicipalityAges 18–40 - NCT06471426Recruiting
Osteopathic treatment for neck pain and headaches
This study tests whether a type of hands-on treatment called osteopathic manipulation can help relieve neck pain and headaches. It's for people who have had these symptoms for more than a month.
Auburn, AlabamaAges 19–65 - NCT06471790Recruiting
Wearable sensor study for walking after epidural
This study tests a small, wearable sensor to track how well you walk after receiving a low-dose epidural during labor. The goal is to see if the sensor can help doctors monitor your recovery and safety.
LyonAges 18–40 - NCT06473597RecruitingPhase 4
Comparing Nurtec and Maxalt for migraine in the ER
This trial tests two fast-dissolving migraine medicines, Nurtec ODT and Maxalt MLT-ODT, in adults coming to the emergency room with a migraine. The goal is to see which one works better and faster for pain relief.
Brooklyn, New YorkAges 18–65 - NCT06584409Recruiting
Laser Acupuncture vs Standard for Migraine – Blood Test Study
This trial tests whether laser acupuncture can help migraines by checking two substances in your blood (MMP2 and CGRP). You may be able to join if you have migraines and are not pregnant.
Taichung, TaichangAges 18 years+ - NCT06617832Recruiting
Evaluating migraine treatment designs
This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.
Aarhus CAges 18–65 - NCT06670053Recruiting
Testosterone and brain development in teens
This study looks at how starting testosterone therapy affects brain development in transgender and gender-diverse youth. It may help you and your doctor understand the changes to expect.
Aurora, ColoradoAges 12–20 - NCT06684249Recruiting
Comparing nerve block and Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (injection near the nerves in the head) and Botox injections. It aims to see which one works better to reduce headache days and improve quality of life.
Zagazig, Sharqia ProvinceAges 18–65 - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT06711731Recruiting
Registry for spinal CSF leak and post-dural headache
This registry collects information from people with suspected spinal CSF leak (a condition where fluid leaks from around your spine) or headaches after a spinal procedure. By joining, you help researchers learn more about these conditions and improve future care.
Freiburg im BreisgauAges Any age - NCT06788977Recruiting
Migraine treatment in pregnancy with a nerve stimulation device
This trial tests if a device that gently stimulates a nerve on your forehead can safely treat migraines during pregnancy. You'll use the device at home and track your headaches via text or email.
Darien, ConnecticutAges 18–44 - NCT06848166RecruitingEarly Phase 1
Middle meningeal artery embolization for resistant chronic migraine
This study tests a procedure called 'middle meningeal artery embolization' using a special glue-like material (SQUID) to treat chronic migraine that hasn't responded to other treatments. The goal is to see if blocking blood flow to the membrane around the brain can reduce migraine attacks.
Bishkek, BishkekAges 35–59 - NCT06959004Recruiting
Does substance P trigger migraine attacks without aura?
This study tests whether a substance called substance P can cause migraine attacks in people who have migraine without aura. Results may help understand new ways to prevent or treat migraine.
Glostrup MunicipalityAges 18–65 - NCT06996600Recruiting
Study of a device to check CSF shunt flow and headaches
This trial is testing a wearable thermal device that checks if your CSF shunt is working properly. It may help understand if your headaches are linked to shunt problems. The study involves using the device at home for 30 days and going to a few follow-up visits.
Chicago, IllinoisAges 6–80 - NCT07015411Recruiting
Neuro supplements for migraine prevention
This trial tests whether a combination of vitamins and supplements can help prevent migraines. It's for adults who have migraines often (at least 6 days per month) and want to try a non-drug option.
MechelenAges 18–75 - NCT07021859Recruiting
Migraine with aura study using CGRP to trigger attacks
This study tests whether a substance called CGRP (a protein linked to migraines) can safely trigger a migraine with aura in people who already have this condition. You'll receive an infusion and be monitored to see how your body responds.
Glostrup MunicipalityAges 18–65 - NCT07040813RecruitingPhase 3
Two migraine medicines together for chronic migraine
This trial tests whether using both a CGRP antibody and Botox together works better than the CGRP antibody alone for chronic migraine. It may help if you have not tried these treatments before.
GrålumAges 18–70 - NCT07058636Recruiting
Nerve block plus trigger point shots for neck pain relief
This study tests if adding a nerve block to standard trigger point injections provides better relief for people with chronic neck pain caused by myofascial pain syndrome.
AnkaraAges 18–65 - NCT07097792Recruiting
Concussion recovery support program for headaches
This study tests a support program for young people who have had a concussion and are still having headaches. It aims to help them recover and feel better.
Seattle, WashingtonAges 18–29 - NCT07103694Recruiting
Migraine drug database study
This study is building a database to learn more about migraine drugs. It may help researchers find better treatments for people with episodic or chronic migraine.
Milan, ItalyAges 18 years+
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 165 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.