Clinical trials · California
Health clinical trials in California
We’re tracking 344 recruiting health studies with a site in California — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT04970056Recruiting
Pancreatic cancer risk and early-detection registry study
This study builds a database of people at higher risk for pancreatic cancer (or certain early warning findings) to help find better ways to detect the disease early. You may be asked to complete health questionnaires and possibly donate a blood/saliva/swab sample.
Burbank, CaliforniaAges 18–90 - NCT05002751Recruiting
Measuring how radiation affects vaginal narrowing in cervical cancer
This study measures how radiation therapy changes the vagina’s flexibility and shape in people with newly diagnosed, advanced cervical cancer that has spread to nearby lymph nodes. The goal is to better understand what happens over time, which may help guide prevention and treatment of vaginal narrowing.
La Jolla, CaliforniaAges 18–99 - NCT05006482RecruitingPhase 3
Geriatric education and care support for older cancer survivors
This study tests whether a structured health education and “older adult care” approach—done with your oncology team—can improve support for people after cancer. It includes older cancer survivors and a chosen caregiver, using in-person or video visits for follow-up.
Fremont, CaliforniaAges 18 years+ - NCT05059444Recruiting
Blood test study to watch for cancer coming back
This study looks at whether blood tests can detect signs that cancer may return after curative-intent treatment. You would have blood drawn around your usual follow-up visits for up to 5 years, and your de-identified health data would be shared with study investigators.
Redwood City, CaliforniaAges 18 years+ - NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT05213676RecruitingPhase 4
Testing stopping inhaled nitric oxide in newborns with CDH
This trial studies whether stopping inhaled nitric oxide (a breathing medicine) can be safely used in newborns with congenital diaphragmatic hernia (CDH). It may help the team decide the best way to use this medicine during early newborn care.
Irvine, CaliforniaAges birth–1 month - NCT05218044Recruiting
Cryoablation for small DCIS instead of breast surgery
This trial studies whether cryoablation (freezing abnormal breast tissue) can treat DCIS, a non-invasive early breast cancer, without surgical lumpectomy. It aims to see if a less invasive approach could help people with small, limited-area DCIS while avoiding some effects of surgery.
Glendale, CaliforniaAges 18 years+ - NCT05229341Recruiting
Testing DNA “methylation” to evaluate thyroid nodule samples
This study looks at patient tissue from needle biopsies to see if DNA “methylation” patterns can help diagnose and guide treatment for thyroid nodules. You might benefit by helping improve how these nodules are evaluated, using information from your biopsy sample and medical data.
Duarte, CaliforniaAges 18 years+ - NCT05245695Recruiting
Endometriosis test using deep computer learning during surgery
This trial studies whether a computer (deep neural network) can better identify endometriosis in people with long-lasting pelvic pain using information from surgery. It may help doctors sort who has endometriosis more accurately when surgery is already planned.
Burbank, CaliforniaAges 14–50 - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT05362292RecruitingPhase 4
Treating bladder leakage to support mind and body health
This study tests medicines to reduce “urgency” urine leakage (when you suddenly feel you must go) and to see whether improving bladder control also helps overall mental and physical health. You may be eligible if you have had these symptoms for at least 3 months and can follow the study plan.
Palo Alto, CaliforniaAges 60 years+ - NCT05380401Recruiting
DHA and ARA milk fats for very early preterm babies
This study looks at how adding two specific milk fats (DHA and ARA) through enteral feeding affects metabolism in very early preterm infants. It may help researchers understand what these nutrients do in babies born around 25–30 weeks gestation.
Los Angeles, CaliforniaAges Up to 8 months - NCT05399537RecruitingPhase 3
Testing citrate fluid safety during kidney filtration (CRRT)
This Phase 3 study checks whether Prismocitrate 18 is safe for adults who need a kidney filtration treatment called CRRT. It is mainly for people who cannot safely use heparin (a common blood thinner) due to bleeding risk.
Los Angeles, CaliforniaAges 18 years+ - NCT05410977Recruiting
Testing blood and stool for colon cancer in Lynch syndrome
This study collects blood and stool samples to see how well they can detect colorectal cancer or advanced growths in people with Lynch syndrome (an inherited colon cancer risk) or suspected Lynch syndrome. It may help find cancer or precancer earlier, which can improve next-step decisions.
San Francisco, CaliforniaAges 18 years+ - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Los Angeles, CaliforniaAges 18 years+ - NCT05428007RecruitingPhase 2
Sarilumab with three immunotherapy drugs for advanced melanoma
This Phase 2 trial tests whether adding sarilumab (an immune-blocking medicine) to three immunotherapy medicines can shrink unresectable, advanced melanoma that cannot be removed with surgery. It aims to improve how well the immune system controls the cancer, especially in Stage III or Stage IV disease.
Los Angeles, CaliforniaAges 18–100 - NCT05440851Recruiting
Testing different treatments for severe breathing failure in ICU
This platform trial studies which treatment works best for adults with sudden, severe breathing failure needing oxygen or a breathing machine in the ICU. It may help patients by matching them to the most appropriate treatment strategy and tracking outcomes to improve care.
San Diego, CaliforniaAges 18 years+ - NCT05452031Recruiting
Sleep program for people with dementia and their caregiver
This study tests a “dyadic” sleep health approach, meaning it works with both you and your caregiver together. It aims to improve sleep when dementia is causing frequent sleep problems, and to see whether a caregiver-involved plan helps both of you.
Los Angeles, CaliforniaAges 18 years+ - NCT05468437Recruiting
Online nutrition coaching for people with spinal cord injury
This study tests whether telenutrition (nutrition coaching by phone/tablet) can help people with spinal cord injury manage their weight and health. It may be a good fit if you’re mainly using a wheelchair, can use an iPad, and live in California.
San Jose, CaliforniaAges 20 years+ - NCT05470023Recruiting
Imaging study of gum health and mouth biofilm
This study uses imaging to look at how healthy your gums are and how much “plaque/biofilm” is in your mouth. It may help researchers better understand gum health and how oral hygiene affects it.
Irvine, CaliforniaAges 18 years+ - NCT05471232Recruiting
Genomic testing for youth mental health crises with IDD
This study looks at genetic (DNA) information to understand mental health crises in youth with intellectual and developmental disabilities. It may help doctors learn why these crises happen and improve how future families are supported.
San Diego, CaliforniaAges 7–17 - NCT05475262Recruiting
Inpatient sleep study using white noise
This study looks at whether playing white noise helps people sleep better while they are in the hospital. If you’re an adult admitted for several days, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT05483855Recruiting
Telehealth coaching to improve care for rheumatoid arthritis
This trial studies a health program delivered by phone or video (telehealth) to help improve care for people with rheumatoid arthritis. It may be helpful if you prefer getting support at home and want to see if this approach improves your care.
Beverly Hills, CaliforniaAges 19 years+ - NCT05516277Recruiting
Insomnia care study for older adults with PTSD
This study tests a treatment plan for insomnia (trouble sleeping) in older adults who also have post-traumatic stress disorder (PTSD). The goal is to see whether improving sleep also supports heart and metabolic health (such as blood sugar and heart-related measures).
North Hills, CaliforniaAges 50 years+
Where these studies are running in California
Institutions with a site for the recruiting health studies listed above.
- University of California, Los Angeles (UCLA) · 5 studies
- University of California, San Francisco · 4 studies
- University of California San Diego Health · 3 studies
- Cedars-Sinai Medical Center · 2 studies
- City of Hope Comprehensive Cancer Center · 2 studies
- Hoag Memorial Hospital Presbyterian · 2 studies
- Rady Children's Hospital San Diego · 2 studies
- University of California, Irvine · 2 studies
What taking part in a health study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Common questions
- Are there health clinical trials in California?
- Yes. We're currently tracking 344 recruiting health studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a health study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a health trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New health studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.