Clinical trials
High Grade Squamous Intraepithelial Lesions clinical trials
Below are recruiting high grade squamous intraepithelial lesions clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06626230RecruitingPhase 1
Safety of curcumin for anal precancer
This study tests whether a curcumin (turmeric) suppository can safely treat anal precancerous changes called AIN 2 or AIN 3. It may be an option if you have high-grade cell changes and want to avoid more invasive treatments.
Atlanta, GeorgiaAges 30 years+ - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age - NCT05334004RecruitingPhase 1
Lopinavir/ritonavir for high-grade anal disease in adults
This early-phase study (Phase 1) tests how safe and tolerable the medicine lopinavir/ritonavir is for adults with HIV and biopsy-confirmed high-grade anal dysplasia. It may help find a possible treatment option for people at higher risk, while also checking for side effects and whether the study plan can be followed.
Madison, WisconsinAges 18 years+ - NCT06206564RecruitingPhase 2
Artesunate ointment for anal precancer in HIV-negative adults
This trial tests an artesunate ointment to treat high-grade anal precancer (HSIL) in people who do not have HIV. The goal is to see if the ointment can clear the abnormal cells caused by HPV.
Chicago, IllinoisAges 18 years+ - NCT06356012RecruitingPhase 4
Imiquimod for high-risk HPV cervical lesions
This trial tests if imiquimod cream can help clear high-grade cervical lesions caused by high-risk HPV. It may be an option for people who want to avoid surgery.
BarretosAges 25–45 - NCT07047989RecruitingPhase 1
NWRD09 for HPV-16 related cervical high-grade changes
This trial tests a new drug called NWRD09 for women with high-grade cervical cell changes (CIN 2/3) caused by HPV type 16. The goal is to see if the drug can help clear these abnormal cells without needing surgery.
BeijingAges 18–65 - NCT07175662RecruitingPhase 2
A new treatment for HPV-related high-grade cervical changes
This study tests a new treatment (NWRD08) for women with high-grade cervical changes (CIN 2/3) caused by HPV types 16 or 18. It aims to see if the treatment can help clear the abnormal cells and prevent them from becoming cancer.
Beijing, Beijing MunicipalityAges 18–60 - NCT05282095Recruiting
Study how HPV changes affect outcomes in CIN2
This study follows women with an early abnormal cervix cell change (CIN2/CIN2-3) to see how HPV DNA “integration” relates to whether the condition improves or worsens. It may help doctors better predict prognosis and guide safer monitoring, especially if you want to become pregnant.
Fuzhou, FujianAges Up to 45 years - NCT05405270Recruiting
Testing how well imiquimod works for abnormal cervix cell changes
This study looks for ways to predict who will respond to imiquimod cream for precancerous cervical cell changes (CIN2 or CIN3). Results may help doctors choose the best treatment approach and better plan follow-up.
BredaAges 18 years+ - NCT06075264RecruitingPhase 2
Artesunate ointment for high-grade vulvar lesions
This trial tests an artesunate ointment for women with high-grade vulvar lesions caused by HPV. It aims to see if the ointment can help the lesions heal or disappear without needing surgery.
Fort Myers, FloridaAges 18 years+ - NCT06052033Recruiting
Light therapy vs. laser for persistent cervical changes with HPV
This study compares two treatments—photodynamic therapy using a special light-activated cream and a CO2 laser—to see which works better for clearing low-grade cervical changes caused by a long-lasting high-risk HPV infection. The goal is to find a safe, effective option for women who have had this condition for over a year.
Wenzhou, ZhejiangAges 18–65 - NCT07029152Recruiting
Anal cancer screening for gay and bisexual men on PrEP
This study is screening gay and bisexual men for anal cancer by taking a swab sample. It aims to find early signs of cancer so it can be treated early.
BrugesAges 35 years+ - NCT07480902Recruiting
Comparing two tests for cervical cancer detection
This trial compares a liquid-based cytology test with a molecular screening test to find early changes in the cervix that could lead to cancer. It may help you understand which test is better at detecting these changes before they become serious.
Mexico City, Mexico CityAges 18–85 - NCT07572396RecruitingPhase 2
HPV treatment with vaginal suppositories for mild cervical changes
This study tests a new vaginal medication (Dysplasix) to treat mild cervical cell changes caused by high-risk HPV. The goal is to see if this treatment can help your body clear the virus and prevent these changes from getting worse.
Shatin, New TerritoriesAges 18–65 - NCT04131413RecruitingPhase 1
HPV vaccine given through the skin for HPV16 cervical disease
This early-phase study tests a vaccine designed to help your immune system fight HPV16, a type of human papillomavirus linked to abnormal cells in the cervix. You may or may not be living with HIV, and the team will check safety and immune response after giving the vaccine in a specific way.
Birmingham, AlabamaAges 19 years+ - NCT07454915RecruitingPhase 2
PVX4 vaccine for HPV16-related cervical dysplasia
This trial tests a new vaccine called PVX4 for women with HPV16-related cervical dysplasia. It aims to see if the vaccine can help clear the high-risk HPV infection and the abnormal cells on the cervix.
The Bronx, New YorkAges 18–60 - NCT06982976Recruiting
Light therapy for abnormal cervical or vaginal cells
This trial tests a light-based treatment (photodynamic therapy) for high-grade or persistent low-grade abnormal cells in the cervix or vagina. It aims to destroy these cells without surgery, which may be an option for patients who want to avoid more invasive procedures.
Beijing, Beijing MunicipalityAges 18–65 - NCT06797986RecruitingPhase 1/Phase 2
Vaccine for HPV-positive head and neck cancer
This trial tests an investigational vaccine called BVAC-E6E7 for head and neck cancer caused by HPV types 16 or 18 that has come back or spread. It is for people who have already tried standard treatments like platinum chemo or immunotherapy, or can't take them.
SeoulAges 19 years+
Hear when a new High Grade Squamous Intraepithelial Lesions trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for high grade squamous intraepithelial lesions?
- Yes. Clin2 currently lists 18 recruiting high grade squamous intraepithelial lesions studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade squamous intraepithelial lesions trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade squamous intraepithelial lesions trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.