Clinical trials
HIV clinical trials
Below are recruiting hiv clinical trials, each written for real people, not researchers. We’re tracking 583 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05804461Recruiting
PrEP support study for Latino gay and bisexual men in Puerto Rico
This study tests ways to help Latino men who have sex with men use PrEP, a medicine that helps prevent HIV. You may be invited if you are HIV-negative (or your status is unknown), are not currently on PrEP, and can read and write Spanish.
San JuanAges 21–99 - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT05753683Recruiting
Online group talks to build social support for young women
This study tests whether online discussion groups can increase social support for young Black/African American women who have had recent substance use. It also specifically focuses on women who are HIV negative and not using PrEP, to support healthier choices and community connection.
Durham, North CarolinaAges 18–30 - NCT05769023Enrolling by invitation
Pilot test targeting HIV prevention for people who inject drugs
This pilot program studies where HIV risk is highest and uses that information to decide how prevention efforts should be delivered. If you’ve used opioids recently and you inject drugs, you may be invited to participate to help reduce HIV risk.
Baltimore, MarylandAges 18 years+ - NCT05729256Recruiting
Study on alcohol and impulsive sexual choices in gay men
This study looks at how heavy drinking may affect “heat of the moment” sexual decisions and related thinking. You may be able to take part if you meet specific recent sex and drinking criteria.
Boston, MassachusettsAges 18 years+ - NCT05723653Recruiting
Cell phone social support for people not in HIV care
This study tests a social support intervention delivered through a “support person” (a confidant) to help people stay engaged in HIV care and improve viral suppression. It may help by strengthening support outside of clinic visits and making care easier to follow.
Birmingham, AlabamaAges 18–49 - NCT05700474Recruiting
Wellness support program for people with HIV or prevention needs
This trial tests an education and support program to improve overall wellness for adults who have HIV or are seeking HIV prevention services. It also looks at people who have had alcohol or substance use recently.
Charlotte, North CarolinaAges 18 years+ - NCT05694637Enrolling by invitationPhase 4
Support to help daily smokers with HIV stay abstinent
This Phase 4 study tests a smoking-quit support approach (reinforcement and coaching) to help people with HIV stop smoking and stay smoke-free. It may help improve smoking abstinence while you continue HIV care.
Francistown, Central DistrictAges 18 years+ - NCT05663502Recruiting
Donate blood and tissue samples for HIV-related cancer research
This study collects blood and tissue samples to help researchers learn more about cancers related to HIV/AIDS. You may be able to join if you’re 18+ and have HIV and a cancer diagnosis, or (if HIV-negative) a certain cancer that is closely linked to AIDS-related cancers.
La Jolla, CaliforniaAges 18 years+ - NCT05654883Enrolling by invitation
Study of mpox immunity in people who were vaccinated or infected
This observational study looks at how your body’s defenses work against mpox (monkeypox), based on blood and health information. You may be eligible if you recently got an mpox vaccine or have had mpox infection and are now out of isolation.
New York, New YorkAges 18–100 - NCT05630638RecruitingPhase 4
Doravirine dose testing during pregnancy for breastfeeding mothers
This study tests how to best dose doravirine for pregnant people with HIV who plan to breastfeed after delivery. The goal is to keep the HIV treatment working safely for both pregnancy and breastfeeding.
Cape TownAges 18 years+ - NCT05633056Recruiting
Testing TB medicines for people with drug-resistant TB and HIV
This trial studies a treatment plan for people who have both drug-resistant tuberculosis (TB) and HIV. It focuses on starting a specific TB medication (bedaquiline) and, if needed, HIV treatment soon after enrollment to see what approach works best.
Durban, KwaZulu-NatalAges 18 years+ - NCT05580458RecruitingPhase 1/Phase 2
Shingles vaccine study for adults with well-controlled HIV
This Phase 1/2 study tests how safe and how well a shingles (varicella zoster) vaccine works in adults living with HIV whose immune status is measured by CD4 count, plus a healthy comparison group. It may help researchers understand whether the vaccine can safely boost protection in people with HIV.
Bethesda, MarylandAges 18 years+ - NCT05553236Recruiting
Using gene testing to guide treatment for drug-resistant tuberculosis
This study uses next-generation gene testing to help manage active drug-resistant tuberculosis. It may help doctors choose the most appropriate treatment by better identifying the TB’s drug resistance.
Cape TownAges Any age - NCT05529342Enrolling by invitation
Long-term follow-up for a prior gene-cell treatment
This study follows people long-term after receiving a specific gene-cell treatment called AGT103-T. It helps researchers check long-term safety and outcomes, which can guide future care for others.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05528237Enrolling by invitation
HPV self-test to help cervical cancer screening access
This trial studies whether letting people collect their own HPV test sample (a private, at-home option) makes cervical cancer screening easier for people with HIV and/or those who are often underserved. If you’ve declined a Pap test or it’s been 6+ months since your last screening, this may offer a more convenient way to check for HPV and cervical cancer risk.
Seattle, WashingtonAges 25 years+ - NCT05537935RecruitingPhase 4
Low-dose naltrexone for nerve pain in people with HIV
This trial studies whether a low dose of naltrexone can reduce long-lasting nerve-related pain in adults living with HIV. It may help if your pain has been ongoing and you have stable HIV control.
Atlanta, GeorgiaAges 18–75 - NCT05470491RecruitingPhase 1/Phase 2
Haploidentical bone marrow transplant with GVHD prevention drugs
This trial tests a reduced-intensity bone marrow transplant from a related donor (haploidentical), using medicines to help prevent a serious complication called GVHD. It is for people with certain blood cancers and aims to improve outcomes by balancing transplant benefit with lower treatment intensity.
Bethesda, MarylandAges 12–120 - NCT05495906RecruitingPhase 4
Lower-dose HPV vaccine study for women with HIV
This trial tests whether giving a lower dose of the HPV vaccine can still be effective and safe for women living with HIV. It may be helpful if you need HPV protection and the study’s dose schedule could reduce vaccine burden.
Surrey, British ColumbiaAges 18–45 - NCT05463692Enrolling by invitation
Study of STI prevention and sexual health in Alabama women
This study follows women in Alabama to better understand sexual health and STI prevention over time. You may be able to join if you recently had an STI report and you’re currently negative for HIV, gonorrhea, and syphilis.
Birmingham, AlabamaAges 18–89 - NCT05418868RecruitingPhase 1
Long-acting cabotegravir injection safety in healthy adults
This Phase 1 study tests how the body handles a long-acting (slow-release) cabotegravir injection combined with a drug called hyaluronidase. It also checks safety and side effects in healthy adults to help future HIV-prevention or treatment plans.
Orlando, FloridaAges 18–55 - NCT05452564RecruitingPhase 2
Baricitinib to help reduce HIV in the brain
This Phase 2 study tests baricitinib to see if it can lower HIV activity in the brain (CNS) for people already on stable HIV treatment. If you have well-controlled HIV in your blood, this trial looks for additional benefit inside the nervous system.
Atlanta, GeorgiaAges 18–65 - NCT05389423RecruitingPhase 1
Pomalidomide plus chemotherapy for HIV-related lymphoma
This Phase 1 study tests whether a combination of pomalidomide and a dose-adjusted chemotherapy plan (EPOCH), with or without rituximab, can treat certain aggressive B-cell lymphomas in people living with HIV. It aims to find a safe dosing approach and see how well the treatment works for specific lymphoma types or high risk of spread to the brain.
Bethesda, MarylandAges 18–120 - NCT05413122RecruitingPhase 2/Phase 3
Smoking quit support for adults living with HIV in South Africa
This trial tests smoking-cessation interventions to help people living with HIV quit smoking or smoke less. You may be eligible if you smoke, are actively engaged in HIV treatment, and can follow the study for about a year.
Soweto, GautengAges 18 years+
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Common questions
- Are there clinical trials for hiv?
- Yes. Clin2 currently lists 583 recruiting hiv studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hiv trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hiv trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.