Clinical trials
Immune Deficiency clinical trials
Below are recruiting immune deficiency clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04232085RecruitingPhase 2
Stem cell transplant to rebuild immunity in genetic immune disorders
This Phase 2 trial tests a stem cell (bone marrow) transplant approach to restore bone marrow function and immune function in people with certain inherited immune problems. If you have one of these conditions and a suitable donor, the study may offer a path to rebuild blood and immune systems.
Baltimore, MarylandAges 4 months–50 years - NCT01852370Enrolling by invitationPhase 1/Phase 2
Lung and bone marrow transplant plan for immune system disorders
This early-phase study tests a step-by-step transplant approach: first replacing the lungs, then doing a bone marrow (stem cell) transplant to treat certain immune deficiency diseases. It may help people whose immune problem has led to severe, end-stage lung disease.
Pittsburgh, PennsylvaniaAges 5–45 - NCT07648264RecruitingPhase 3
Immune Boost Treatment After CAR-T or TCE Therapy
This study tests a new immunoglobulin (antibody) treatment called IgPro20 in adults whose immune systems became weakened after receiving CAR-T cell or TCE therapies for blood cancers. The goal is to help strengthen your immune system and reduce infection risk.
Orange, CaliforniaAges 18 years+ - NCT05584488Recruiting
Study of immune and allergy patterns over time
This study follows people with suspected or known inherited immune/allergy problems by collecting health information and blood. It may help researchers understand how immune systems and allergies behave over time and support future studies.
New York, New YorkAges Up to 99 years - NCT02735824Recruiting
Genetic study of immune problems in children
This study looks for new genetic causes of immune system conditions that can run in families. If you join, researchers will collect health information (and usually samples) from children with immune concerns and from close relatives for comparison.
Zurich, Canton of ZurichAges Any age - NCT07284641RecruitingPhase 2
Stem cell transplant for immune disorders
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
Pittsburgh, PennsylvaniaAges 5–40 - NCT00128973Recruiting
Study immune system problems in people with unusual infections
This study looks at how the immune system works in people who have abnormal immune function, often shown by unusual or repeated infections or long-lasting inflammation. It may involve tests using blood samples and storage of blood for future research.
Bethesda, MarylandAges Any age - NCT05306925Recruiting
Arginine supplement study for newborns after major gut surgery
This study looks at whether giving an amino-acid supplement called arginine to newborns after major bowel surgery can improve the baby’s immune response. It may help doctors understand how to support recovery after conditions like necrotizing enterocolitis or certain birth defects.
Liverpool, MerseysideAges 5 months–10 months - NCT07195006Recruiting
Malnutrition in pregnancy and child growth study
This study looks at how nutrition during pregnancy affects the health of mothers and babies, including gut health and growth. It compares women with low nutrition to those with healthy nutrition.
HarareAges 18 years+ - NCT05421325RecruitingPhase 2
Vaccine-like immune treatment to prevent lung infections in seniors
This Phase 2 study tests a site-specific immune “booster” in people age 65 and older to help improve natural immunity and reduce respiratory (lung/airway) infections. You may be eligible if you can consent, are in an eligible living situation, and are not currently using certain immune-suppressing medicines.
Burnaby, British ColumbiaAges 65 years+ - NCT04448951Recruiting
Study of immune response in early sepsis or septic shock
This trial looks at how the immune system behaves in the first day after septic shock begins. It may help researchers find better ways to support the body’s immune balance during sepsis, but you must be enrolled very quickly.
Pilsen, Česká RepublikaAges 18 years+ - NCT06475469Recruiting
Immune system in untreated CLL and infection risk
This study looks at how the immune system works in people with untreated CLL and tries to find ways to predict who might get infections. It aims to help doctors better protect patients from infections in the future.
ReimsAges 18 years+ - NCT07552038Recruiting
Dental Care Management for People Living With HIV
This study looks at how dentists can best care for people with HIV. Researchers will review dental and health records at hospitals in the Pays de la Loire region to understand what works best for keeping teeth and gums healthy when you have HIV.
Nantes, NantesAges 18 years+ - NCT07339189Recruiting
AI Suicide Prevention for Older Adults With HIV
This trial tests a smartphone-based AI program designed to help people with HIV who have had suicidal thoughts. It aims to reduce suicide risk by teaching coping skills through text-based conversations.
Newark, New JerseyAges 50 years+ - NCT07251179Recruiting
Understanding immune cells in autoimmune diseases and immune deficiencies
This study looks at immune cells in people with certain autoimmune diseases or immune deficiencies. The goal is to understand how these cells work, which may help improve future treatments.
StrasbourgAges 18–70 - NCT06278337Recruiting
Moesin-associated immunodeficiency study
This study looks at a rare immune system condition caused by changes in the MOESIN gene. It aims to better understand the condition and may help develop future treatments.
Bethesda, MarylandAges 4–80 - NCT06999954Recruiting
Global survey for Shwachman-Diamond syndrome and related conditions
This trial is a global survey and registry for people with Shwachman-Diamond Syndrome and related inherited blood disorders. It aims to connect patients, families, and researchers to better understand these conditions and improve care.
Woburn, MassachusettsAges Any age - NCT06926894RecruitingPhase 1
A cell therapy for viral infections in children and young adults
This trial tests a special immune cell treatment (R-MVST cells) for children and young adults who have had a stem cell or organ transplant and are fighting stubborn viral infections like EBV, CMV, ADV, or BK virus. The goal is to see if these cells can help control the viruses when standard medicines haven't worked well enough.
New York, New YorkAges 3 months–26 years - NCT03266653RecruitingPhase 2
T-cell therapy for stubborn Epstein-Barr virus after transplants
This trial tests an immune therapy made from EBV-targeted T-cells to treat EBV infections that do not improve with standard anti-viral medicines. It may help by strengthening the body’s ability to fight EBV after certain transplants or immune problems.
Los Angeles, CaliforniaAges 1 month–79 years - NCT03266640RecruitingPhase 2
CMV cell therapy for difficult-to-treat viral infection
This trial tests an immune cell treatment (CMV-specific cytotoxic T cells) for people with a CMV infection that is not improving despite standard antivirals, or who cannot tolerate them. If eligible, the treatment aims to help the body control the virus after transplant-related immune problems.
Los Angeles, CaliforniaAges 1 month–79 years - NCT03266627RecruitingPhase 2
Adenovirus T-cell therapy for hard-to-treat virus after transplants
This trial tests a special immune-cell treatment made to fight adenovirus in people whose adenovirus infection keeps coming back or won’t improve after transplant. It may help control infection when standard antiviral medicines are not working or can’t be tolerated.
Los Angeles, CaliforniaAges 1 month–79 years - NCT06689800Recruiting
Family communication tool for kids getting transplant or cell therapy
This study looks at a family communication tool for children and teens getting stem cell transplants or cellular therapy. It helps families talk about treatment together.
St Louis, MissouriAges 8 years+ - NCT06519734Recruiting
Immune Deficiency, IUDs and Menstrual Products Study
This study looks at how well women with primary immune deficiencies can use intrauterine devices (IUDs) and other menstrual products. It aims to help doctors and patients make better choices for safe and effective period care.
ParisAges 18 years+ - NCT03016806Recruiting
Umbilical cord blood transplant from unrelated donors
This trial studies transplanting healthy blood-forming cells from an umbilical cord blood donor who is not related to you. It may help people with certain blood cancers, immune disorders, or other serious diseases when a standard transplant plan is needed.
Rochester, New YorkAges 2 months–75 years
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Common questions
- Are there clinical trials for immune deficiency?
- Yes. Clin2 currently lists 39 recruiting immune deficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a immune deficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a immune deficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.