Clinical trials
Knee Arthroplasty clinical trials
Below are recruiting knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 235 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT07124494Recruiting
Anesthesia type and recovery after knee replacement
This study compares two types of anesthesia for total knee replacement to see which helps with pain, movement, and satisfaction after surgery. If you are scheduled for a knee replacement and are willing to have a spinal or epidural anesthesia, you may be able to join.
Konya, MeramAges 18 years+ - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT07629388Recruiting
Nerve block for pain after knee replacement surgery
This trial tests whether adding a nerve block (a numbing injection near the nerve) to the usual pain plan can better control pain after a total knee replacement. The goal is to help you recover with less pain and fewer side effects.
DijonAges 18 years+ - NCT06787417RecruitingPhase 4
Knee alignment study for total knee replacement
This study compares two different surgical techniques for total knee replacement to see which one leads to better knee movement and function. If you need a knee replacement due to arthritis, this trial may help find the best approach for your surgery.
Hamilton, OntarioAges 18 years+ - NCT07362589Enrolling by invitation
Does pain education before knee or hip replacement help?
This study tests whether a special education session before knee or hip replacement surgery can help reduce anxiety, pain, and the need for pain medicine after surgery. If you are scheduled for joint replacement and can take part in a short learning session, you may be eligible.
Istanbul, KayişdağiAges 18 years+ - NCT03869996Recruiting
Fast-track recovery for knee replacement patients
This trial studies a faster recovery “fast-track” plan for people getting their first total knee replacement for arthritis. It may help by getting you back to movement and normal life sooner, while comparing outcomes against usual care.
BolognaAges 18–78 - NCT05936814Recruiting
Study measures knee alignment in severe varus osteoarthritis
This study focuses on people age 65+ with severe “varus” knee alignment osteoarthritis (wear-and-tear arthritis that affects how the knee lines up). It aims to use your knee measurements and data to better understand the condition and guide care.
AnkaraAges 65 years+ - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT05302934Recruiting
Testing a knee-surgery app and sensor after knee replacement
This trial checks whether a data platform that uses a wearable sensor and a phone app works well for people getting a total knee replacement. It may help make follow-up care more organized and easier by capturing recovery information.
Konstanz, Baden-WurttembergAges 18 years+ - NCT06298721Recruiting
Personalized care to improve knee replacement satisfaction
This study tests a personalized approach to knee replacement surgery designed for people who are at higher risk of being dissatisfied after the procedure. The goal is to see if tailoring care based on patient-reported outcomes can improve satisfaction.
Cleveland, OhioAges 18–80 - NCT06701474Recruiting
Knee replacement recovery: comparing body composition groups
This study looks at how well people recover after total knee replacement, comparing those with different body composition levels. The goal is to see if a measure called 'phase angle' affects recovery of strength and function.
Yongin-si, Gyeonggi-doAges 55 years+ - NCT07767097Recruiting
Low-dose radiation after revision knee replacement for stiffness
This study tests whether a single low dose of radiation after revision knee replacement surgery can help reduce stiffness and improve knee movement in people who had a stiff knee after their first replacement. The radiation is given along with usual care after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT06800846Enrolling by invitationPhase 4
Pain relief after knee replacement: injection methods compared
This study compares two ways to give pain medicine during knee replacement surgery: one is injected into the bone, the other around the joint. Researchers want to see which works better and may help you recover with less pain.
Khlong Luang, Changwat Pathum ThaniAges 50–80 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT06321042Recruiting
Knee replacement study using sensor-guided implant placement
This study tests whether using small motion sensors during knee replacement surgery leads to better outcomes. It is for people aged 50–84 with severe knee pain from arthritis or bone damage who are scheduled for a first-time cemented total knee replacement.
Bologna, ItaliaAges 50–85 - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05461651Recruiting
Preventing knee infections after knee replacement
This study looks at ways to lower the risk of infection after knee replacement surgery (with or without vancomycin, an antibiotic). If you’re a good candidate, you may receive an approach aimed at preventing post-surgery infections and related complications.
Otwock, Masovian VoivodeshipAges 40 years+
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Common questions
- Are there clinical trials for knee arthroplasty?
- Yes. Clin2 currently lists 235 recruiting knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.