Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06080347Recruiting
Anti-inflammatory diet for knee osteoarthritis
This study tests whether an anti-inflammatory diet can help with knee osteoarthritis. If you have OA in one knee and are open to changing your eating habits, you may be able to join.
San Diego, CaliforniaAges 18 years+ - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT07481461Recruiting
Knee alignment and biology in osteoarthritis
This study looks at how changes in knee alignment affect symptoms and joint biology in people with early knee osteoarthritis. It may help doctors understand how to better treat knee OA.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06507046Recruiting
Personalized total knee replacement study in Norway
This trial is studying a more personalized approach to total knee replacement surgery. It is for people with moderate to severe knee arthritis who are already scheduled for a knee replacement at Kristiansund Hospital in Norway.
Kristiansund, Møre and RomsdalAges 18–80 - NCT06557018RecruitingPhase 4
Numbing medicine injection for knee replacement pain
This study tests a long-lasting numbing medicine (liposomal bupivacaine) injected around the knee during total knee replacement surgery. It aims to see if this medicine helps control pain and reduce the need for other painkillers after surgery.
Dezhou, ShandongAges 18–80 - NCT06627673Recruiting
A new knee implant study for severe arthritis
This study compares a new plastic-and-metal knee implant to a standard metal one for people with severe knee arthritis. If you need a total knee replacement and your knee is not too bent or twisted, you may be a candidate.
Leawood, KansasAges 18 years+ - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06490770Recruiting
Understanding knee pain and function
This study looks at how your knee joint works when you have pain or limited function. It uses MRI and electrical stimulation to learn more about cartilage and meniscus damage, which might help improve future treatments.
BolognaAges 18–60 - NCT07367789Recruiting
Predicting recovery after knee replacement using smart insoles
This study uses special insoles to measure how you walk before and after a knee replacement. The goal is to see if these measurements can help predict how well you will recover after surgery.
Yongin-si, Gyeonggi-doAges 19 years+ - NCT04145401Enrolling by invitation
Long-term follow-up for a specific knee revision implant
This study tracks how well a particular knee revision implant performs over many years. It may help you by closely monitoring your knee after revision surgery and adding to long-term safety and performance data.
Englewood, ColoradoAges 21 years+ - NCT06129214Recruiting
Partial tendon cleaning to reduce knee clicking after replacement
This trial studies a partial cleaning procedure on the quadriceps tendon during knee replacement to reduce clicking or rubbing sensation (crepitus). It is only for people getting a specific type of knee implant (posterior-stabilized) and whose kneecap is not replaced.
Seoul, GangnamGuAges 19 years+ - NCT03869996Recruiting
Fast-track recovery for knee replacement patients
This trial studies a faster recovery “fast-track” plan for people getting their first total knee replacement for arthritis. It may help by getting you back to movement and normal life sooner, while comparing outcomes against usual care.
BolognaAges 18–78 - NCT06127719Recruiting
Surgery wait time and knee replacement quality of life
This study looks at how waiting for knee replacement surgery affects your quality of life. It may help doctors understand how to improve care for people waiting for surgery.
Hoorn, North HollandAges 18–100 - NCT07555067Enrolling by invitation
Robotic Knee Replacement Surgery Comparison
This trial compares two different robotic systems used during knee replacement surgery for knee arthritis (wear and tear). The study helps doctors understand which robotic system may provide better results.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18 years+ - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT07383740Recruiting
Reliability of a gentle bike test for hip or knee osteoarthritis
This study checks whether a simple, low-effort bike test gives consistent results for people with hip or knee osteoarthritis. It helps doctors understand how well this test can measure your fitness without pushing you too hard.
GothenburgAges 30 years+ - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75 - NCT06685120Recruiting
PRP and hyaluronic acid for knee osteoarthritis
This study tests a combination of platelet-rich plasma (PRP) and hyaluronic acid injections for knee osteoarthritis. It aims to see if these injections together can reduce pain and improve function better than standard treatments.
BolognaAges 40–75 - NCT06843980Recruiting
Knee implant trial for inner knee pain
This trial tests a knee implant for people with pain on the inner side of the knee that gets worse with activity. It may be an option if other non-surgical treatments haven't helped.
Davis, CaliforniaAges Any age - NCT04230616Recruiting
Testing a knee device to ease osteoarthritis pain
This study tests how well and how safely a knee treatment works for adults with painful knee osteoarthritis seen on X-ray. You might join if you need meaningful pain relief and help with daily function, and can complete required scans and study instructions.
Sint-Truiden, LimburgAges 18 years+ - NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Phoenix, ArizonaAges Any age - NCT05839535RecruitingPhase 2
Baduanjin plus brain stimulation for knee osteoarthritis pain
This Phase 2 study tests whether combining Baduanjin (a guided mind-body movement) with neuromodulation can improve knee osteoarthritis symptoms and function. It compares education-based stretching/control and uses MRI scanning as part of the research.
Charlestown, MassachusettsAges 45–75
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 408 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.