Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 390 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT04145401Enrolling by invitation
Long-term follow-up for a specific knee revision implant
This study tracks how well a particular knee revision implant performs over many years. It may help you by closely monitoring your knee after revision surgery and adding to long-term safety and performance data.
Englewood, ColoradoAges 21 years+ - NCT06129214Recruiting
Partial tendon cleaning to reduce knee clicking after replacement
This trial studies a partial cleaning procedure on the quadriceps tendon during knee replacement to reduce clicking or rubbing sensation (crepitus). It is only for people getting a specific type of knee implant (posterior-stabilized) and whose kneecap is not replaced.
Seoul, GangnamGuAges 19 years+ - NCT03869996Recruiting
Fast-track recovery for knee replacement patients
This trial studies a faster recovery “fast-track” plan for people getting their first total knee replacement for arthritis. It may help by getting you back to movement and normal life sooner, while comparing outcomes against usual care.
BolognaAges 18–78 - NCT03734900RecruitingPhase 4
Comparing two knee injection treatments for osteoarthritis
This study compares two knee injection treatments for knee osteoarthritis. It aims to see which one works better for reducing pain and improving function, so you might experience less knee pain and better mobility.
TaipeiAges 50–80 - NCT06127719Recruiting
Surgery wait time and knee replacement quality of life
This study looks at how waiting for knee replacement surgery affects your quality of life. It may help doctors understand how to improve care for people waiting for surgery.
Hoorn, North HollandAges 18–100 - NCT07555067Enrolling by invitation
Robotic Knee Replacement Surgery Comparison
This trial compares two different robotic systems used during knee replacement surgery for knee arthritis (wear and tear). The study helps doctors understand which robotic system may provide better results.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18 years+ - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT04230616Recruiting
Testing a knee device to ease osteoarthritis pain
This study tests how well and how safely a knee treatment works for adults with painful knee osteoarthritis seen on X-ray. You might join if you need meaningful pain relief and help with daily function, and can complete required scans and study instructions.
Sint-Truiden, LimburgAges 18 years+ - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75 - NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT07472088Recruiting
Knee pain study using weight-bearing CT scans
This trial uses a special CT scan taken while you stand to see how the shape of your knee joint relates to your knee pain. It may help researchers better understand knee arthritis and front-of-knee pain.
Kansas City, KansasAges 18 years+ - NCT07449442Recruiting
Pain relief study after knee replacement surgery
This trial tests a special injection around the knee to improve pain control after knee replacement surgery. It may help reduce the need for strong pain medicines.
PoznanAges 65–100 - NCT07383740Recruiting
Reliability of a gentle bike test for hip or knee osteoarthritis
This study checks whether a simple, low-effort bike test gives consistent results for people with hip or knee osteoarthritis. It helps doctors understand how well this test can measure your fitness without pushing you too hard.
GothenburgAges 30 years+ - NCT07380906Recruiting
Knee artery embolization for knee arthritis registry
This trial is testing a procedure called genicular artery embolization (GAE) to treat knee osteoarthritis. If your knee pain hasn't improved with standard treatments like medicine, this study may be a way to try something new.
Libertyville, IllinoisAges 18 years+ - NCT07288970Recruiting
Comparing two numbing injections for knee replacement pain
This study compares two types of numbing injections (nerve blocks) to see which provides better pain relief after total knee replacement surgery. If you are 65 or older and having your first knee replacement, you may be able to join.
PoznanAges 65–100 - NCT06899932Recruiting
Genutech knee replacement survival study
This study tracks how long Genutech knee replacements last in people with knee arthritis. It is for adults whose arthritis did not improve with non-surgical treatments like physical therapy or medication.
Barcelona, BarcelonaAges 18 years+ - NCT06934421Recruiting
A new approach for knee radiofrequency ablation
This trial tests a revised method for radiofrequency ablation to treat chronic knee pain from severe osteoarthritis (KL grade III or IV). It aims to see if the procedure can help patients who haven't gotten relief from standard treatments like physical therapy, painkillers, and steroid injections.
FaroAges 18 years+ - NCT06383936Recruiting
Knee replacement for active sports lovers
This study tests a new knee replacement designed for active people ages 40 to 65 who used to play sports but had to stop due to knee pain. It aims to see if the implant helps you return to your favorite activities.
BolognaAges 40–65 - NCT07055113Recruiting
Home rehab program for hip or knee arthritis
This study tests a home-based rehab program for people with hip or knee arthritis who do not need joint replacement yet. It aims to help improve function and reduce pain through online sessions.
Edmonton, AlbertaAges Any age - NCT06957444Enrolling by invitation
Allergic skin reactions and scar appearance after joint replacement
This study looks at how often patients have an allergic skin reaction to the stitches used after knee or hip replacement, and how their scar looks. If you are having a first-time replacement, you may be able to join.
Morgantown, West VirginiaAges 18–80 - NCT06932614Recruiting
Growth factor vs PRP for knee arthritis
This trial compares two injections—a special growth factor treatment and a platelet-rich plasma (PRP) injection—to see which works better for knee osteoarthritis. It aims to help people with mild to moderate knee arthritis who have had pain for at least 3 months.
TaipeiAges 20–80
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 390 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.