Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06994546Recruiting
ArtiBest injection for knee osteoarthritis pain
This trial tests a new hyaluronic acid injection called ArtiBest for people with mild to moderate knee osteoarthritis who haven't gotten enough relief from other treatments like physical therapy or pain pills. It aims to see if the injection can reduce knee pain and improve function.
Kaohsiung CityAges 35–85 - NCT06616896Recruiting
Vibration exercise for knee osteoarthritis
This study tests whether a special vibrating exercise program can improve knee pain and function in people with knee osteoarthritis. It compares this new rehab approach to standard exercise.
TaipeiAges 50–80 - NCT07426549Recruiting
Knee Exercises With Blood Flow Restriction for Osteoarthritis
This study compares two types of knee exercises (closed chain and open chain) with a special blood flow restriction technique to see which helps reduce pain and improve function in people with mild to moderate knee osteoarthritis.
RawalpindiAges 45–75 - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT06857123Recruiting
Rest breaks during exercise for knee osteoarthritis
This study is testing whether adding short rest breaks during exercise can help people with knee osteoarthritis feel better and stick with a program. It may be a good option if you have mild to moderate knee pain and are not very active right now.
Pittsburgh, PennsylvaniaAges 45–79 - NCT07001761Recruiting
Ultrasound study for knee osteoarthritis
This study uses ultrasound imaging to evaluate knee osteoarthritis in people over 30 with painful knees. It aims to better understand how the condition appears on imaging.
SohagAges 30 years+ - NCT07652437Recruiting
Wearable device study for knee osteoarthritis walking
This study tests whether a wearable device can help people with knee osteoarthritis walk more easily and for longer periods. If you have knee pain or stiffness on most days and find walking difficult, this might help you improve your mobility.
Cambridge, MassachusettsAges 21–100 - NCT07478861Enrolling by invitation
Vibration training for seniors with knee arthritis and obesity
This study tests whether whole-body vibration training can help older adults who have both severe knee arthritis and obesity. It aims to improve strength, mobility, and quality of life.
Banī SuwayfAges 60–75 - NCT06623149Enrolling by invitation
Surgery vs. non-surgery for knee arthritis
This study compares non-surgical treatments with knee replacement surgery for people with knee osteoarthritis. It aims to find out which approach works better.
Copenhagen, CopenhagenAges Any age - NCT03484325Enrolling by invitation
Patient registry for joint replacement and related surgeries
This trial is a “registry,” meaning it collects information from people who choose certain elective joint surgeries. It may help doctors better understand outcomes and safety after procedures like hip and knee operations.
Houston, TexasAges 18–100 - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT06251752Recruiting
Long-term study of kneecap after knee realignment surgery
This study looks at how well the kneecap joint holds up many years after a knee realignment surgery (high tibial osteotomy) for inner knee arthritis. If you had this surgery more than 5 years ago, you may be able to join a long-term checkup that uses X-rays and medical records to see how your knee is doing.
BolognaAges 18–65 - NCT07589127Recruiting
Nerve Block for Pain Relief During Knee Replacement
This study tests whether blocking a specific nerve in the knee can reduce pain and improve recovery after total knee replacement surgery. You would receive this nerve block alongside standard anesthesia to see if it helps you need fewer pain medications afterward.
Hjelset, Møre og RomsdalAges 18–80 - NCT07324746Recruiting
Herbal supplement for osteoarthritis pain
This trial tests whether a herbal supplement helps people with osteoarthritis of the knee or hip feel less pain and move better. If you have moderate to severe pain and are able to walk, this study might be a good fit.
LondonAges 18 years+ - NCT07721116Recruiting
AI Study of Knee Imaging and Treatment Results
This study uses artificial intelligence (AI) to better understand knee images from healthy people and those with knee arthritis. It aims to predict how well knee injections might work for you.
Taipei, TaiwanAges 18 years+ - NCT06893302Recruiting
Bone marrow injection during knee scope for cartilage or meniscus
This trial tests if adding a bone marrow injection to standard knee arthroscopy helps your knee heal better. It is for people with a torn meniscus or damaged cartilage who have healthy knee joints without arthritis.
New York, New YorkAges 18–64 - NCT07313020Enrolling by invitationEarly Phase 1
Handheld imaging to track stem cells in knee osteoarthritis
This trial tests a new handheld imaging device (MPI) to track stem cells injected into the knee. It aims to see if the device can safely monitor how the stem cells move and work in people with knee osteoarthritis.
Haikou, HainanAges 18–75 - NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT03519269Recruiting
Robotic versus standard knee replacement for severe knee arthritis
This study compares a robotic-assisted knee replacement to a standard (non-robotic) knee replacement. It may help people with severe knee arthritis learn which approach improves pain and knee function after surgery.
New York, New YorkAges 40–85 - NCT07701174Recruiting
Weighted exercise vs muscle stimulation for knee arthritis
This study compares two treatments for knee osteoarthritis: weighted dangling exercises and neuromuscular electrical stimulation of the knee muscle. It aims to see which one reduces pain and improves function better.
Lahore, Punjab ProvinceAges 40–60 - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT05800457Recruiting
Test synovectomy to reduce pain after knee replacement
This study looks at whether a procedure called synovectomy (removing inflamed joint lining) can reduce pain after a first knee replacement on one side. It focuses on people with clear signs of inflammation on ultrasound and checks follow-up outcomes after surgery.
London, OntarioAges 41–80 - NCT06040827Recruiting
Study of a knee implant extension for knee replacement
This trial is for adults having their first knee replacement surgery. It tests a special part (tibial extension) of a common knee implant system. Researchers will follow participants over time to see how well it works.
Fayetteville, ArkansasAges 18 years+
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 408 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.