Clinical trials
Knee Surgery clinical trials
Below are recruiting knee surgery clinical trials, each written for real people, not researchers. We’re tracking 81 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07767383RecruitingPhase 4
Improving sleep quality after knee surgery with added sedation and nerve blocks
This trial tests whether adding a calming medicine called dexmedetomidine to a nerve block around the knee can help you sleep better after arthroscopic knee surgery. It aims to find if this combination reduces sleep problems during recovery.
Nantong, JiangsuAges 18–85 - NCT06532929Recruiting
Recovery after sports surgery with Teknimed products
This study is checking how well people recover after sports surgery using Teknimed products. It is for patients who had or will have a surgery with these products, and aims to see how the products perform in real life.
Aubenas, ArdècheAges 18 years+ - NCT06802419Recruiting
Comparing two types of knee nerve blocks for pain relief after knee surgery
This study compares two types of nerve blocks—one that numbs the front of the thigh and one that adds extra numbing behind the knee—to see which provides better pain relief after arthroscopic knee surgery (like ACL or PCL repair). The goal is to help patients have less pain and recover more comfortably.
CairoAges 21–65 - NCT07002580Recruiting
Knee surgery pain relief: nerve block comparison
This study compares two types of nerve blocks (iPACK and adductor canal block) to see which provides better pain relief after arthroscopic knee surgery. It may help you have less pain and recover faster.
SakaryaAges 18–50 - NCT07109557Recruiting
Baduanjin for recovery after knee replacement
This study tests whether doing Baduanjin, a gentle mind-body exercise, helps people recover better after knee replacement surgery. It focuses on patients who are in stable condition and willing to try the exercise.
YalovaAges 18–70 - NCT07151417RecruitingPhase 2/Phase 3
Steroid injection during total knee replacement
This study tests whether adding a corticosteroid (a type of anti-inflammatory medicine) to the standard pain injection during total knee replacement can improve pain relief. It is for adults getting their first knee replacement at certain military hospitals.
Bethesda, MarylandAges 18 years+ - NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT07522736Recruiting
Spinal anesthesia with dexmedetomidine for knee surgery
This trial tests adding dexmedetomidine (a calming medication) to bupivacaine (numbing medication) injected into the spine during knee surgery. The goal is to improve pain relief and recovery after surgery.
CairoAges 18–65 - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT07552415Recruiting
Joint Immobilization After Knee Replacement Revision Surgery
This study tests whether keeping your knee still for a period after revision knee replacement surgery helps improve how well you can bend and straighten it. Researchers want to see if immobilization (using a brace or cast) helps you regain better movement compared to standard care.
New York, New YorkAges 18 years+ - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT06809842Recruiting
Nerve blocks for pain after knee surgery
This study compares two nerve blocks—one to a muscle nerve and one to a skin nerve—to see which works better for pain after knee surgery. If you're having knee surgery, these blocks could help you recover with less pain and fewer side effects.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT06562634Enrolling by invitation
Ultrasound-guided nerve block for knee surgery pain relief
This study tests a nerve block (erector spinae plane block) to see if it reduces pain after open knee surgery. It aims to find a better way to manage pain with fewer side effects.
CairoAges 18–65 - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT03858231RecruitingPhase 4
Opioid vs non-opioid pain relief after knee arthroscopy
This study compares opioid pain medicine with non-opioid pain medicine after arthroscopic (keyhole) knee surgery. It aims to see which approach controls pain well while keeping side effects and risks lower.
Fargo, North DakotaAges 18–80 - NCT06188806Recruiting
Nerve block location study for knee replacement pain
This study compares two types of nerve blocks (proximal vs. distal adductor canal block) for pain relief after knee replacement surgery. The goal is to see which approach provides better pain control and recovery.
Istanbul, UmraniyeAges 18–85 - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06856356Recruiting
Robot-assisted knee replacement surgery study
This study tests if robot-assisted total knee replacement surgery is safe and effective. It may help people who need knee replacement surgery by using advanced technology for more precise implant placement.
Hefei, AnhuiAges 18–80 - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+
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Common questions
- Are there clinical trials for knee surgery?
- Yes. Clin2 currently lists 81 recruiting knee surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.