Clinical trials
Knee Surgery clinical trials
Below are recruiting knee surgery clinical trials, each written for real people, not researchers. We’re tracking 77 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT07454356Recruiting
Device to help knee bending after replacement
This study tests a non-surgical device called Knee Flexionater to help people who have limited knee bending after total knee replacement. The goal is to improve knee motion and avoid a second surgery.
Houston, TexasAges 40 years+ - NCT07671430Recruiting
Psychological care before ACL surgery
This trial tests if extra psychological support before anterior cruciate ligament (ACL) surgery helps people who are very afraid of the operation. You would attend remote counseling sessions to see if they improve your recovery.
ParisAges 18 years+ - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65 - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85 - NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT06733597Recruiting
Bone density change after knee replacement with or without cement
This study looks at how bone density in the thigh bone changes after knee replacement surgery, comparing two ways of attaching the new joint (with cement or without). It may help people who have normal bone density or early bone thinning but not full osteoporosis.
Madison, WisconsinAges 55 years+ - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT05675618Recruiting
Returning to Golf After Joint Replacement Surgery
This study focuses on helping people get back to golfing after common orthopedic (bone/joint) surgeries like hip or knee or shoulder replacement. You may be asked to complete follow-up questionnaires to track recovery and return-to-golf progress.
New York, New YorkAges 18 years+ - NCT07131579Enrolling by invitation
Dexmedetomidine via IV for knee surgery pain
This trial tests adding a medicine called dexmedetomidine to the numbing IV used during knee surgery. It aims to see if it provides better pain relief after surgery under spinal anesthesia.
Al MansurahAges 18–60 - NCT07065266Enrolling by invitation
Pain survey for ACL knee surgery patients
This trial is testing a simplified pain questionnaire for people who are having ACL knee surgery. The goal is to see if this shorter questionnaire can effectively measure pain levels after surgery.
Redwood City, CaliforniaAges 18 years+ - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55 - NCT04109638Recruiting
PEMF therapy to reduce pain after shoulder or knee surgery
This trial studies whether PEMF, a type of non-surgical device that uses pulsed electromagnetic fields, can reduce pain after shoulder or knee surgery. If you join, you’ll also be expected to do post-surgery physical therapy exercises and report your pain and function.
Redwood City, CaliforniaAges 18 years+ - NCT05389410Recruiting
PICO dressings compared during repeat hip or knee surgery
This study compares two types of wound dressings (PICO 7 vs PICO 14) in people having a repeat (revision) hip or knee operation. It aims to see which dressing works better to help the surgical wound heal after surgery.
Oswestry, ShropshireAges 18 years+ - NCT07464860Recruiting
Breathwork for older adults after knee surgery
This study tests a breathing exercise program to help older adults recover after knee replacement surgery. Participants practice controlled breathing at home using a smartphone or computer.
Tucson, ArizonaAges 65 years+ - NCT06759116Recruiting
Comparing two pain medicines for knee surgery recovery
This trial tests whether adding fentanyl or dexmedetomidine to a standard numbing medicine (bupivacaine) provides better pain relief after knee surgery. It may help find the best option for patients undergoing knee procedures like total knee replacement or ACL repair.
El SharkiaAges 21–85 - NCT06910150Enrolling by invitation
Pain relief after knee surgery: electric stimulation study
This trial tests two types of mild electric stimulation (one with tiny needles, one without) applied to the thigh muscle to reduce pain in people who had ACL knee surgery in the last six weeks. The goal is to see if this can help you feel better and recover quicker.
Madrid, MadridAges 18–55 - NCT05112302Enrolling by invitation
Virtual reality during orthopedic anesthesia
This study tests whether using virtual reality during hip or knee surgery (while you’re receiving a nerve block for anesthesia) helps make the experience more comfortable. You’d try the VR during your procedure, and the team will compare outcomes with usual care.
Jackson, FloridaAges 18 years+ - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70 - NCT07016243Recruiting
Knee recovery and ankle movement after knee replacement
This study looks at how well patients can move their ankle after knee replacement surgery and whether it affects their knee recovery. It may help improve rehabilitation for future patients.
Bagheria, PalermoAges 65–85 - NCT07607249Enrolling by invitation
Floating Needle Treatment for Stomach Issues After Knee Surgery
This trial tests whether a traditional Chinese acupuncture technique called 'floating needle' can help with stomach and bowel problems that sometimes happen after knee surgery under general anesthesia. You would receive this treatment along with standard post-surgery care to see if it reduces nausea, constipation, or other digestive issues.
Guangzhou, GuangdongAges 18 years+ - NCT07548567Recruiting
Nerve Block to Reduce Pain During Below-Knee Fracture Surgery
This study tests a nerve-blocking injection (numbing medicine around the femoral artery nerve in your groin area) to help reduce pain and blood pressure changes during below-knee fracture surgery when a tourniquet (pressure cuff) is used. The goal is to see if this approach makes surgery more comfortable and safer.
AthensAges 18 years+ - NCT07023185Recruiting
Cold and compression after knee replacement
This study will test if adding cold and compression therapy after knee replacement surgery can help with pain, swelling, and recovery. You may qualify if you are 50 or older and having a knee replacement with a specific surgeon.
New Orleans, LouisianaAges 50 years+
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Common questions
- Are there clinical trials for knee surgery?
- Yes. Clin2 currently lists 77 recruiting knee surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.