Clinical trials
Leptomeningeal Disease clinical trials
Below are recruiting leptomeningeal disease clinical trials, each written for real people, not researchers. We’re tracking 11 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05800275RecruitingPhase 2
Tucatinib and capecitabine plus spinal trastuzumab for HER2+ cancer
This Phase 2 trial tests a combination of tucatinib and capecitabine (taken by mouth) plus trastuzumab delivered into the spinal fluid, to treat breast cancer that has spread to the leptomeninges (lining around the brain/spinal cord). It may help reduce cancer activity in the spinal fluid and improve symptoms.
BordeauxAges 18 years+ - NCT06417710Recruiting
Standardized check-up for leptomeningeal metastasis
This study watches and writes down how patients with cancer that has spread to the brain or spinal cord lining (leptomeningeal metastases) are doing. It helps doctors learn more about this condition without giving any new treatments.
Houston, TexasAges 18 years+ - NCT07415018Recruiting
Better MRI contrast for detecting cancer spread to brain lining
This study is testing different ways to give MRI contrast dye to better see if cancer has spread to the lining of the brain (leptomeningeal disease). It's for people with solid tumors who have had unclear results on standard scans or who are at high risk but have negative tests.
Houston, TexasAges 18 years+ - NCT06146010Recruiting
German leptomeningeal disease registry study
This study collects information from people with leptomeningeal disease, a condition where cancer spreads to the lining of the brain and spinal cord. By joining, you help researchers learn more about this disease and how it affects people.
BonnAges 18 years+ - NCT05112549RecruitingPhase 1
PD-1 antibody placed into brain fluid for metastatic cancer
This early-phase study tests a PD-1 antibody delivered directly into the brain fluid (intrathecal space) to treat metastatic solid tumors that have spread to the lining around the brain/spinal cord (leptomeningeal disease). It aims to see whether this approach can better control cancer in that area and whether it’s safe.
BonnAges 18 years+ - NCT05257967Recruiting
Testing spinal fluid in EGFR-mutant lung cancer with brain covering spread
This trial looks at spinal fluid (also called CSF) in adults with EGFR-mutant lung cancer that has spread to the lining around the brain/spinal cord. The goal is to better understand the disease and what the spinal fluid tests may show to guide care.
Vancouver, British ColumbiaAges 18 years+ - NCT02422641RecruitingPhase 2
High-dose methotrexate for breast cancer in the brain lining
This Phase 2 trial tests whether giving high-dose methotrexate into the bloodstream can help treat breast cancer that has spread to the thin lining covering the brain and spinal cord. It may help reduce cancer in the leptomeningeal (brain-lining) area and control symptoms.
Baltimore, MarylandAges 18 years+ - NCT06910761RecruitingPhase 2
Radiation for cancer spread to brain lining
This trial tests whether a precise type of radiation to the brain and spine (craniospinal irradiation) can help control cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease) in people with breast cancer or non-small cell lung cancer. The goal is to improve symptoms and slow disease progression.
Duarte, CaliforniaAges 18 years+ - NCT07476781Recruiting
Liquid biopsy study for solid tumours and brain tumours
This study collects samples of spinal fluid and blood from people with solid tumours that have spread to the brain or spine, or who have primary brain tumours. The goal is see if these samples can help doctors detect and monitor these cancers more easily.
Toronto, OntarioAges 18 years+ - NCT06016387RecruitingPhase 2
Drug combo with radiation for HER2+ breast cancer spread to spinal lining
This trial tests a combination of three targeted drugs (tucatinib, trastuzumab, and capecitabine) along with radiation to the brain or spine for people whose HER2-positive breast cancer has spread to the lining of the brain or spinal cord. The goal is to see if this treatment is safe and effective.
Ottawa, OntarioAges 18 years+ - NCT07694986RecruitingPhase 2
Vaccine therapy for breast cancer that has spread to the brain and spinal cord
This trial tests a new type of vaccine (dendritic cells) injected directly into the spinal fluid, combined with either trastuzumab (if your breast cancer is HER2-positive) or nivolumab (if your breast cancer is HER2-negative). The goal is to see if this combination can better control breast cancer that has spread to the lining of the brain and spinal cord.
Tampa, FloridaAges 18 years+
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Common questions
- Are there clinical trials for leptomeningeal disease?
- Yes. Clin2 currently lists 11 recruiting leptomeningeal disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a leptomeningeal disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a leptomeningeal disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.