Clinical trials
Locally Recurrent Rectal Cancer clinical trials
Below are recruiting locally recurrent rectal cancer clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05186116Recruiting
Liver transplant for colon cancer that cannot be removed
This trial studies whether liver transplant (rather than removing the liver tumors) can help some people with colon or rectal cancer spread to the liver. It’s meant for people whose cancer has responded or stayed controlled on standard treatments and who have no cancer outside the liver.
Modena, MOAges 18–77 - NCT04087421RecruitingPhase 3
Transanal irrigation vs glycerol suppositories for LARS
This trial compares two ways to help bowel control in people with low anterior resection syndrome (LARS) after low rectal surgery. It aims to see which option works better when standard treatments have not helped enough.
AarhusAges 18 years+ - NCT06850103RecruitingPhase 2
Chemo, radiation, and immunotherapy for advanced rectal cancer that has spread a little
This trial tests a combination of chemotherapy, radiation, and an immunotherapy drug (serplulimab) for people with rectal cancer that has spread to just a few spots in the body (no more than 5 tumors in up to 2 locations). It aims to see if this approach is safe and effective.
Hangzhou, ZhejiangAges 18–75 - NCT06923150Recruiting
MiniGo vs. standard care for bowel symptoms after rectal cancer surgery
This trial tests a small, portable device called MiniGo that uses a gentle water rinse to help control bowel symptoms after rectal cancer surgery. It may be an option for people who still have bothersome bowel problems despite trying other treatments.
AmiensAges 18 years+ - NCT02704520Recruiting
MRI scoring test for rectal cancer response to treatment
This study looks at how an MRI “score” (mrTRG) matches how well locally advanced rectal cancer shrinks after pre-surgery chemotherapy and radiation. The goal is to use MRI results to better predict treatment response and guide care.
Aberdeen, AberdeenshireAges 16 years+ - NCT07573371Recruiting
Understanding bowel changes after rectal cancer surgery
This study helps doctors better understand and treat bowel control problems that can happen after rectal cancer surgery or other rectal treatments. If you've had this surgery or treatment, the study team wants to learn more about your recovery and test new ways to help.
AalborgAges 18 years+ - NCT07651553Recruiting
Transanal vs. Robotic Surgery for Rectal Cancer
This trial compares two surgical approaches to remove rectal cancer while preserving bowel function. Researchers want to see which method—performed through the anus or with robotic assistance—leads to better outcomes and quality of life.
Guangzhou, GuangdongAges 18–75 - NCT05482516RecruitingPhase 3
Testing blood test–guided treatment for GI cancers in remission
This Phase 3 study tests whether giving treatment based on a positive blood test for “minimal cancer signals” (ctDNA) can help people with certain GI cancers stay cancer-free longer. It focuses on people who have finished curative-intent therapy and currently have no visible disease on scans, but their blood test is still positive.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07542262Enrolling by invitationPhase 2
Low-dose immunotherapy for advanced colorectal and stomach cancer
This study tests a lower dose of immunotherapy in patients with colorectal or stomach cancer that has spread or cannot be removed by surgery. The cancer must have a specific genetic feature (MSI/dMMR). The goal is to see if this approach works well with fewer side effects.
MoscowAges 18 years+ - NCT06523634Recruiting
SBRT for rising PSA after prostate removal
This trial tests a precise type of radiation (called SBRT) to the prostate bed for men whose PSA starts rising after prostate removal surgery. It aims to see if this targeted approach can effectively treat the recurrence without needing long-term hormone therapy.
AalstAges 18 years+ - NCT05597852Recruiting
Rectal gel spacer to help repeat prostate radiation
This trial studies whether placing a soft gel spacer near the rectum can make “salvage” prostate radiation safer and more tolerable when prostate cancer comes back locally. It may help reduce side effects by creating extra space between the rectum and the radiation area.
Toronto, OntarioAges 18 years+ - NCT04165772RecruitingPhase 2
Dostarlimab for locally advanced mismatch-repair deficient solid tumors
This Phase 2 trial studies dostarlimab (an immune therapy that targets PD-1) given before surgery or other initial treatment. It aims to shrink certain locally advanced cancers that have mismatch repair deficiency, potentially making treatment easier and improving outcomes.
Hartford, ConnecticutAges 18 years+ - NCT06279299Recruiting
Lymph node removal for rectal neuroendocrine tumors during laparoscopic surgery
This trial tests whether removing lymph nodes in the pelvis during laparoscopic surgery for rectal neuroendocrine tumors (a type of slow-growing or aggressive tumor) improves outcomes. It is for people with larger or recurrent tumors, or those at higher risk due to tumor grade or depth.
Beijing, Beijing MunicipalityAges 18–75 - NCT05059444Recruiting
Blood test study to watch for cancer coming back
This study looks at whether blood tests can detect signs that cancer may return after curative-intent treatment. You would have blood drawn around your usual follow-up visits for up to 5 years, and your de-identified health data would be shared with study investigators.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for locally recurrent rectal cancer?
- Yes. Clin2 currently lists 62 recruiting locally recurrent rectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a locally recurrent rectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a locally recurrent rectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.