Clinical trials
Lower Limb Amputation clinical trials
Below are recruiting lower limb amputation clinical trials, each written for real people, not researchers. We’re tracking 69 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07276867Recruiting
Spinal Add-On Medicine for Leg Amputation from Sarcoma
This trial tests adding two medicines (dexmedetomidine and fentanyl) versus fentanyl alone to the standard spinal anesthetic for above-knee amputation surgery for lower limb sarcoma. The goal is to see if the combination provides better pain control during and after surgery.
CairoAges 18–60 - NCT05225792Recruiting
Fast rehab program for leg injuries and amputations
This trial tests a rapid rehabilitation approach for people with certain leg injuries, including amputations and limb salvage, while you are already in standard rehab. It may help improve walking and balance after trauma by using a structured training program.
Rochester, MinnesotaAges 18 years+ - NCT06473740RecruitingPhase 4
Gene therapy plus angioplasty for severe leg blockages
This study tests if adding gene therapy to a standard leg artery-opening procedure (angioplasty or stenting) helps people with severe leg pain or non-healing wounds due to blocked arteries. It may improve blood flow and save the leg from amputation.
Blagoveshchensk, Amur OblastAges 18 years+ - NCT06747117Recruiting
Removing blood clots in leg arteries with the Indigo system
This study tests a device that vacuums out blood clots from blocked leg arteries, potentially restoring blood flow without open surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06519175Recruiting
Study of leg problems in children
This study gathers information on children with leg bone or muscle problems (from birth or later) to better understand their conditions. It may help improve future care for kids with similar issues.
BolognaAges Up to 18 years - NCT04658693Recruiting
Restore leg sensation in diabetic nerve damage with safe stimulation
This study tests a treatment that delivers mild stimulation to help bring back lower-limb feeling in people with diabetic nerve damage (or an insensate foot) and may also protect nerves. If you qualify and can safely take part in testing and follow-up, it could improve sensation and walking comfort.
Cleveland, OhioAges 18 years+ - NCT07432685Enrolling by invitation
Can movement predict chronic pain after combat limb injuries?
This study is looking for people with combat-related arm or leg injuries to see if how they move can predict long-term pain. Researchers hope to better understand who might develop chronic pain and help improve treatment.
LvivAges 18–50 - NCT07204925RecruitingPhase 1
Personalizing a computerized leg for above-knee amputees
This trial tests a new way to personalize a computerized prosthetic leg for people who have lost a leg above the knee. It uses smart learning technology to help the leg adjust to how you walk, which may make walking feel more natural.
Raleigh, North CarolinaAges 18–75 - NCT03135847Enrolling by invitation
Using feedback to improve prosthetic movement in amputees
This study tests whether movement “feedback” can help adults with arm or leg amputations control a prosthetic better. It may be most helpful if you can comfortably wear a prosthetic socket and can understand and consent to the study.
Ages 18–75 - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT07057817Recruiting
Using Cerament for heel infections to save the leg
This trial tests a special bone filler called Cerament to treat heel bone infections in people with diabetes, aiming to avoid leg amputation. It may help heal the bone after partial heel removal surgery.
GalwayAges 18 years+ - NCT07135895Recruiting
Artix device for recent leg artery blockages
This study tests a device called Artix to remove blood clots from arteries in the leg that occurred within the last two weeks. It may help restore blood flow and avoid amputation.
New Haven, ConnecticutAges 18 years+ - NCT05112705Recruiting
Finding deep vein clots early in ICU patients
This study focuses on diagnosing deep-vein thrombosis (DVT, blood clots in the leg) early in people who are very ill in the ICU. It aims to test an approach to better detect clots sooner, which could help prevent complications.
Riyadh, Riyadh RegionAges 18 years+ - NCT06476782Recruiting
Motor learning and exercise for stroke recovery
This study tests a combined motor relearning program and aerobic exercise to improve balance and leg function in people recovering from a stroke that happened 1 to 5 months ago. If you qualify, you would receive this therapy to help with your standing stability and walking ability.
Sialkot, Punjab ProvinceAges 50–70 - NCT06525532Recruiting
Tracking reabsorbable implant for flatfoot in kids
This study tracks how well a special reabsorbable implant works over time in children and teens who had subtalar surgery for flatfoot. You'll have an MRI to see how the implant has changed and if it helped your foot.
BolognaAges 8–15 - NCT06796920Recruiting
Spinal cord stimulation for leg problems in adrenomyeloneuropathy
This trial tests a small device placed near your spinal cord (called epidural spinal cord stimulation) to see if it can help improve leg movement and stiffness in people with adrenomyeloneuropathy (AMN). If you have AMN and trouble walking due to leg stiffness, this study may explore a new option for you.
Beijing, Beijing MunicipalityAges 22–50 - NCT07642778Recruiting
Measuring Leg Strength in Kidney Disease Patients on Dialysis
This study measures how strong your leg muscles are in patients with chronic kidney disease who receive dialysis treatment. Understanding normal strength patterns may help doctors better support kidney disease patients' physical health and quality of life.
MadridAges 18–85 - NCT07397390Enrolling by invitation
Study of a new scoring balloon for leg artery blockages with heavy calcium buildup
This study tests a new balloon device that scores the artery walls to treat leg artery blockages with heavy calcium deposits. It aims to see if the device helps prepare the vessel safely and effectively before placing a stent.
Dalian, LiaoningAges 18–85 - NCT07401966Recruiting
Amputation in childhood and nerve pain study
This study looks at nerve pain in children and teens who had an amputation before a certain age. It aims to understand how common and how severe this pain is after amputation, and uses simple questionnaires to find out.
Saint-MauriceAges 5–18 - NCT05929508Recruiting
Rebuilding leg strength after above-knee amputation
This study tests a new approach to improve walking ability and leg function after an above-knee (transfemoral) amputation. It may help by targeting muscle loss and supporting safer, stronger mobility over time.
Chicago, IllinoisAges 18 years+ - NCT07139483Recruiting
Preventing chronic phantom limb pain with mirror therapy and brain stimulation
This study tests whether combining mirror therapy (looking at a reflection of your healthy limb) with a gentle brain stimulation technique called tDCS can prevent phantom limb pain from becoming long-lasting. It is for people who recently had a limb amputated and are already starting to feel phantom pain.
Raanana, IsraelAges 18 years+
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Common questions
- Are there clinical trials for lower limb amputation?
- Yes. Clin2 currently lists 69 recruiting lower limb amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.