Clinical trials
Lower Limb Amputation Below Knee clinical trials
Below are recruiting lower limb amputation below knee clinical trials, each written for real people, not researchers. We’re tracking 32 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06780943Recruiting
Study on how people with leg amputations adapt their walking
This study looks at how people with a leg amputation change the way they walk to make up for lost function. It may help improve rehabilitation and prosthetic care.
NîmesAges 18–80 - NCT06667739Recruiting
Promoting physical activity after leg amputation
This study tests a program to help people who have lost a leg due to diabetes or blood vessel disease become more active. It uses coaching and online modules to support your progress.
Toronto, OntarioAges 18 years+ - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT07384689Recruiting
Study of leg tissue in non-traumatic amputation patients
This study looks at the tissue environment in the legs of patients who need amputation due to non-traumatic causes, like poor blood flow or infection. Understanding the tissue better might help improve healing for future patients.
Aarhus NAges 18 years+ - NCT05830630Recruiting
Methylene blue given during leg amputation surgery
This trial studies whether infusing methylene blue during above- or below-knee leg amputation can improve outcomes for people with poor blood flow to the legs. It targets patients having surgery under general anesthesia, while excluding those with certain allergies or blood clotting problems.
Tanta, Gharbia GovernorateAges 18 years+ - NCT07266077Recruiting
A study of a slope-adapting prosthetic foot for Veterans
This study tests a special prosthetic foot that adapts to slopes (like hills or ramps) to help Veterans with below-knee amputations walk more easily. You would need to visit the Minneapolis VA and use a special foot for a while.
Minneapolis, MinnesotaAges 18–89 - NCT07214493Recruiting
Study of a prosthetic foot with adjustable heel height
This trial tests a prosthetic foot that lets you adjust the heel height so you can comfortably walk in different shoes or barefoot. It is for people with a leg amputation who already use a certain type of prosthetic foot and want more flexibility in their footwear.
ConcarneauAges 18 years+ - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT04953364Recruiting
Tech-based self-management support after a leg amputation
This study tests a technology-based program to help people manage rehabilitation after a lower-limb amputation. It may help by giving structured support for day-to-day care and prosthesis use.
Vancouver, British ColumbiaAges 50 years+ - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT06106984Recruiting
Home rehab for phantom limb pain in Veterans
This study tests a home-based rehab program for Veterans with phantom limb pain after a below-knee amputation. It uses telehealth to help you manage pain without needing to travel to a clinic.
Minneapolis, MinnesotaAges 18–89 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06419920Recruiting
Prosthetic performance enhancement trial
This study tests whether a new prosthetic foot can help people with a lower-limb amputation walk better. You will use your current foot and the new foot, and we will measure how well you walk.
Las Vegas, NevadaAges 18 years+ - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+ - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT07276867Recruiting
Spinal Add-On Medicine for Leg Amputation from Sarcoma
This trial tests adding two medicines (dexmedetomidine and fentanyl) versus fentanyl alone to the standard spinal anesthetic for above-knee amputation surgery for lower limb sarcoma. The goal is to see if the combination provides better pain control during and after surgery.
CairoAges 18–60 - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99
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Common questions
- Are there clinical trials for lower limb amputation below knee?
- Yes. Clin2 currently lists 32 recruiting lower limb amputation below knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb amputation below knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb amputation below knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.