Clinical trials
Lower Limb Amputation clinical trials
Below are recruiting lower limb amputation clinical trials, each written for real people, not researchers. We’re tracking 69 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06106984Recruiting
Home rehab for phantom limb pain in Veterans
This study tests a home-based rehab program for Veterans with phantom limb pain after a below-knee amputation. It uses telehealth to help you manage pain without needing to travel to a clinic.
Minneapolis, MinnesotaAges 18–89 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06419920Recruiting
Prosthetic performance enhancement trial
This study tests whether a new prosthetic foot can help people with a lower-limb amputation walk better. You will use your current foot and the new foot, and we will measure how well you walk.
Las Vegas, NevadaAges 18 years+ - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06645054Recruiting
Testing a smart hallway system in clinics
This trial tests a smart hallway system that may help monitor walking. It is for people who can walk a short distance on their own, have no major memory or thinking problems, and speak Slovenian.
LjubljanaAges 18 years+ - NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+ - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT07486063RecruitingEarly Phase 1
Motorized leg prosthetics for above-knee amputees
This study tests whether a motorized (powered) prosthetic knee and ankle can help people with above-knee amputations walk better. If you already use a mechanical or microprocessor-controlled leg, you may be able to try a new powered version.
Salt Lake City, UtahAges 18–80 - NCT06226844Recruiting
Can a vibration device help people with leg artery disease walk further?
This study tests a device called BeatMove to see if it can improve walking distance for people with blocked leg arteries that cause pain when walking. It may help if you have this condition and already take medicines for it.
NîmesAges 18 years+ - NCT06471855Recruiting
Rehabilitation support for leg amputation due to diabetes
This study is for people with diabetes or blood vessel disease who are at risk for losing a leg, have already had a lower leg amputation, or use a prosthetic leg. It focuses on a rehabilitation program that helps with both physical and emotional adjustment.
Pavia, PVAges Up to 80 years - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75 - NCT07175714Recruiting
Study of walking stumbles and slips
This study tests how well different methods can recreate stumbles and slips while walking. It may help people with and without prosthetic legs understand how to prevent falls.
ReykjavikAges 18 years+ - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75 - NCT03409133Recruiting
Neural feedback training for people with leg amputations
This study tests whether a nerve-based “feedback” system can help people with below-knee or above-knee amputations during standing and walking. It focuses on whether the training and device setup are safe and workable for participants over the study period.
Cleveland, OhioAges 18 years+ - NCT04934839Recruiting
Gait study comparing prosthetic walking types in adults
This study compares how people walk using an osseointegrated prosthesis (a prosthesis connected to the bone) versus a traditional socket prosthesis. It may help researchers understand which option works better for walking balance, comfort, and function.
Milan, MIAges 18 years+ - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT07445035Recruiting
Robotic leg brace to help walking while on a breathing machine
This study tests whether walking with a robotic leg brace (exoskeleton) can help people who are on a breathing machine get better faster. It is for adults in the intensive care unit who can sit, stand with help, and have no major leg or heart problems.
New Taipei CityAges 45–65 - NCT07276867Recruiting
Spinal Add-On Medicine for Leg Amputation from Sarcoma
This trial tests adding two medicines (dexmedetomidine and fentanyl) versus fentanyl alone to the standard spinal anesthetic for above-knee amputation surgery for lower limb sarcoma. The goal is to see if the combination provides better pain control during and after surgery.
CairoAges 18–60
Hear when a new Lower Limb Amputation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for lower limb amputation?
- Yes. Clin2 currently lists 69 recruiting lower limb amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.