Lung Cancer (Suspected or Confirmed) clinical trials

Music therapy for lung cancer surgery patients

This trial tests whether listening to music in the hospital can help reduce distress and pain after surgery for lung cancer. If you are having a minimally invasive surgery (keyhole surgery) to remove part of your lung, you may be able to join.

Breath test for airway inflammation in lung diseases and healthy people

This study is testing a simple breath test (Inflammacheck device) to see if it can measure airway inflammation in people with various lung conditions, including lung cancer, pneumonia, asthma, and COPD, as well as healthy volunteers. It aims to find better ways to diagnose and monitor respiratory diseases using your breath.

Genetic testing for lung cancer risk

This study tests blood, saliva, or tissue samples from people who have a lung nodule or suspected lung cancer. The goal is to find genetic changes that could guide personalized treatment or early detection.

Better COPD care for people evaluated for lung cancer

This trial tests whether people being checked for possible lung cancer can also get improved care for a breathing condition called COPD (chronic obstructive pulmonary disease). It focuses on patients whose lung function tests show airflow problems.

Blood and tumor testing to choose the right lung cancer treatment

This trial tests tumor tissue and a blood sample to help doctors pick the most personalized treatment for people with suspected lung cancer. It may help ensure you get therapy matched to your specific tumor characteristics, especially when the cancer might be surgically removed.

Testing SNB-101 for advanced small cell lung cancer

This study tests a new drug, SNB-101, for people with small cell lung cancer that has spread and has worsened after standard therapy. It aims to find out if SNB-101 can help control the cancer and what side effects it may cause.

Comparing lung biopsy methods for suspected lung cancer

This study compares two ways of doing a lung biopsy with a needle guided by ultrasound. It aims to see which method gives better samples for diagnosing lung cancer.

New marker test for marking colon tumors before surgery

This trial tests a new marker that glows under special light to help doctors see exactly where a colon tumor is during surgery. It may help make the surgery more precise.

Robot vs open surgery for gallbladder cancer

This trial compares robot-assisted surgery to open surgery for people with gallbladder cancer that has been found after a gallbladder removal. The goal is to see which approach is better for the radical removal of remaining cancer.

Spectral CT scans for lung cancer detection

This trial is testing a new way to look at CT scans (called spectral imaging) to see if it can better detect lung cancer in people who are suspected of having it. If you are being referred for lung cancer testing, this study may help doctors get clearer information from your scans.

Fecal transplant to treat cancer immunotherapy bowel side effects

This early-phase study tests whether changing your gut bacteria with a fecal transplant can improve diarrhea or colitis caused by cancer immunotherapy. It may help people whose symptoms have not fully settled with standard treatments like steroids and other immune-blocking medicines.

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Canakinumab to prevent lung cancer from persistent lung nodules

This trial tests canakinumab to lower the risk of lung cancer growing from persistent lung nodules seen on CT scans. It may help people at higher risk who have either never had lung cancer or had early lung cancer treated in the past.

Papaverine with chemoradiation for stage II–III lung cancer

This early-phase trial tests whether adding papaverine to standard chemoradiation can improve treatment for stage II–III non-small cell lung cancer (and some limited stage IV cases). It aims to see if the combination is safe and tolerable while targeting the cancer with radiation and chemotherapy.

Blood test study for early cancer detection in patients

This study collects blood from people with cancer and people without cancer (or with possible cancer) to test whether new blood tests can detect cancer earlier. Your blood samples help researchers evaluate how well these tests work.

Durvalumab plus focused radiation for progressing stage III lung cancer

This trial studies adding focused radiation to some cancer spots in people with stage III non-small cell lung cancer (NSCLC) whose cancer did not fully stop after standard chemoradiation and durvalumab. The goal is to control a small number of growing spots (or more than a few) and improve outcomes after durvalumab.

Virus therapy with chemo and immunotherapy for advanced lung cancer

This trial tests a new treatment that uses a virus to attack cancer cells, combined with standard chemotherapy and an immunotherapy drug, for people with advanced non-small cell lung cancer that has gotten worse after initial treatment. The goal is to see if this combination works better than a different chemotherapy drug alone.

Blood and tissue collection study for certain lung cancers

This study collects blood and tissue samples from people with non-small cell lung cancer (NSCLC) either before or after treatment. It aims to help researchers learn more about how tumors respond, especially in cancers with specific genetic changes or after certain pre-surgery therapies.

Tested medicine for tumors with TrkA changes, alone or with pembrolizumab

This early-phase study tests VMD-928, a targeted cancer medicine, for cancers that have TrkA-related tumor changes. It may be given by itself or with pembrolizumab to see if it can shrink tumors when standard treatments have not worked.

CPI-613 plus hydroxychloroquine with chemo for advanced solid tumors

This trial tests a drug called CPI-613 (devimistat) combined with hydroxychloroquine along with either 5-fluorouracil or gemcitabine chemo. It’s for people with advanced cancers that have stopped responding to standard treatments, aiming to shrink tumors and slow cancer growth.

Microwave ablation for small early lung cancer nodules

This trial studies a flexible “microwave heating” probe placed through the airways to treat small lung cancer nodules. It may help some patients avoid more invasive treatment by destroying the tumor during a bronchoscopy procedure.

Lung cancer testing and treatment outcomes research study platform

This study collects information from adults with different types and stages of lung cancer to connect molecular test results with treatment choices and outcomes. It may help improve how lung cancer is diagnosed and managed by building a better understanding of what works for different patients.

New drug plus chemotherapy for advanced lung cancer

This trial tests a new study drug called PF-08634404 combined with standard chemotherapy for people with advanced lung cancer that has not been treated before. It aims to see if this combination works better than chemotherapy alone.

Study of PF08634404 plus chemo for transformed small cell lung cancer

This trial tests a new study drug (PF08634404) combined with standard chemotherapy for people whose non-small cell lung cancer has changed into a more aggressive form called small cell lung cancer. It hopes to improve outcomes by targeting the cancer in two ways.