Clinical trials
Major Depression Disorder clinical trials
Below are recruiting major depression disorder clinical trials, each written for real people, not researchers. We’re tracking 504 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06728280Recruiting
DTMS for teens with depression: safety and effectiveness
This trial tests if a new type of brain stimulation called DTMS can safely help adolescents with major depression. It may be an option if you have tried other treatments and are looking for a non-medication approach.
Taiyuan, ShanxiAges 11–23 - NCT07314190Enrolling by invitation
Blood tests for brain diseases and mental health conditions
This study looks at blood tests to help diagnose and track brain diseases (like Alzheimer's) or mental health conditions. It compares patients to healthy volunteers to find better ways to detect and monitor these illnesses.
BarcelonaAges 18 years+ - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Bentonville, ArkansasAges 18–75 - NCT07305701Recruiting
Study on Medical Students' Mental Health
This study follows first-year health students at the University of Orléans to understand their mental health over time. It aims to find ways to support students' well-being during their studies.
Orléans, LoiretAges 18 years+ - NCT06740396Recruiting
Depression in heart disease patients in Baghdad
This study looks at how common depression is in people with coronary artery disease and how severe it is. If you have heart disease and are being treated at a hospital in Baghdad, you can help doctors understand the link between heart health and mental health.
BaghdadAges 18 years+ - NCT07282678Recruiting
Adaptive brain stimulation for treatment-resistant depression.
This study tests a new brain stimulation device that adjusts its signal in real time to treat depression. It's for people who haven't gotten enough help from antidepressants and are looking for a non-drug option.
Durham, North CarolinaAges 22 years+ - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Birmingham, AlabamaAges 18–65 - NCT07281729Enrolling by invitation
Suicide risk factors study for mood disorders
This study looks at why some people with mood disorders (like depression or bipolar disorder) think about or attempt suicide. By finding the risk factors, doctors hope to better prevent suicide. The study involves filling out questionnaires.
Shanghai, Shanghai MunicipalityAges 16–60 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Dothan, AlabamaAges 18–65 - NCT06716034Recruiting
Mood and diet pilot trial for teens with depression
This study tests whether a special diet can help improve mood in teens with depression. You and your parent will work together online with the study team.
Toronto, OntarioAges 11–17 - NCT05076214Recruiting
Exercise group for teens with mild to moderate depression
This study compares a structured aerobic exercise group to a more relaxed leisure activity group for adolescents with mild to moderate depression. It aims to see whether exercise can help improve mood when earlier basic support didn’t work well enough.
HalmstadAges 13–17 - NCT07263022RecruitingPhase 3
Cognitive Training for Early Psychosis Study
This study tests whether a cognitive training program can help young adults with recent psychosis improve their thinking and memory skills. It involves brain scans and cognitive exercises.
Minneapolis, MinnesotaAges 18–35 - NCT07263321Recruiting
Depression treatment choice in general practice
This study helps people with moderate depression decide between medication and therapy. Your doctor will work with you to pick the best option.
AalborgAges 18–65 - NCT06311136Recruiting
Mood support through a smartphone app
This trial tests a smartphone-based program designed to help people manage their emotions in the moment. It may be especially helpful if you currently have mild to moderate depression.
HeidelbergAges 18–65 - NCT06410599RecruitingPhase 2
Medication boost for tough-to-treat chronic depression
This trial tests a new medication added to your current treatment for chronic depression that hasn't gotten better with at least two antidepressants and 12 therapy sessions. It might help when standard treatments aren't enough.
Tübingen, Baden-WürtembergAges 18–64 - NCT05435222Recruiting
Male-only therapy program for major depression
This study tests a counseling/psychotherapy program designed specifically for men with major depression. If you qualify, you may be offered this structured therapy and followed to see whether it helps depressive symptoms.
Zurich, Canton of ZurichAges 25–50 - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT07255131Recruiting
Online talk therapy for cystic fibrosis
This study tests an online cognitive behavioral therapy (a type of talk therapy) program designed for people with cystic fibrosis. It aims to help improve mental health and coping skills through 13 video sessions.
AthensAges 18–70 - NCT07250893Recruiting
Resolving early life stress in depression: a psychotherapy study
This trial tests if a specific type of psychotherapy can help people with moderate-to-severe depression who experienced stress or adversity in childhood (before age 18). Researchers want to see how the treatment works in the brain and whether it improves depression symptoms.
Hamilton, OntarioAges 18–65 - NCT07258914Recruiting
Repetitive TMS for depression in adults with autism
This trial tests whether repetitive transcranial magnetic stimulation (rTMS) can safely and effectively treat major depression in adults who also have autism spectrum disorder. rTMS uses magnetic pulses to stimulate specific brain areas without surgery.
RennesAges 18–65 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Iowa City, CaliforniaAges 18–65 - NCT07247344Recruiting
Depression in hospitalized teens: a brain study
This study looks at brain and behavior in teens aged 10–20 who are hospitalized for depression or bipolar disorder. It aims to better understand the condition and may help guide future treatments.
Nanjing, JiangsuAges 10–20 - NCT07230990Recruiting
Brain Stimulation Study for Depression
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
Boston, MassachusettsAges 18–65 - NCT07239843Enrolling by invitation
Study of blood markers and mental health in brain diseases
This study looks at how social factors and blood markers relate to psychiatric symptoms in people with brain diseases or mental disorders. It aims to find new ways to understand and diagnose these conditions.
Barcelona, BarcelonaAges 18 years+
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Common questions
- Are there clinical trials for major depression disorder?
- Yes. Clin2 currently lists 504 recruiting major depression disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.