Clinical trials · San Francisco, CA
Major Depression clinical trials in San Francisco
We’re tracking 43 recruiting major depression studies with a site in or near San Francisco — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near San Francisco
- NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Walnut Creek, CaliforniaAges 18–64 - NCT06775379RecruitingPhase 3
Azetukalner vs. placebo for major depression
This trial tests an investigational medication called Azetukalner against a placebo to see if it helps reduce symptoms of major depressive disorder. You may qualify if you are currently in a depressive episode that started in adulthood and have not tried or failed only a few antidepressants.
Walnut Creek, CaliforniaAges 18–74 - NCT07022405RecruitingPhase 2
Medication study for depression with brain scans
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
Palo Alto, CaliforniaAges 18–65 - NCT04870255Recruiting
Brain stimulation for depression in borderline personality disorder
This study tests a type of brain stimulation called rTMS to see if it can help improve mood in people who have both depression and borderline personality disorder. It may offer a new treatment option for those who haven't tried TMS before.
Stanford, CaliforniaAges 18–80 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Stanford, CaliforniaAges 18–65 - NCT05996900Recruiting
Brain stimulation study for adults with epilepsy
This study uses advanced brain monitoring and noninvasive magnetic stimulation to understand how repetitive brain stimulation works in people with epilepsy who are already scheduled for hospital monitoring. It may help develop better treatments for seizures.
Stanford, CaliforniaAges 18–65 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Stanford, CaliforniaAges 18–85 - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Stanford, CaliforniaAges 18 years+ - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT07188623Recruiting
Virtual reality therapy for older adults with depression
This study tests if a virtual reality program can help older adults with depression become more active and feel better. You would use a VR headset at home to practice activities that improve your mood.
Stanford, CaliforniaAges 65 years+ - NCT06824415Recruiting
Sleep TMS for depression
This trial tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation), given during sleep, can improve depression. It's for adults who have not gotten enough relief from antidepressant medication.
Stanford, CaliforniaAges 18–65 - NCT07369180Enrolling by invitation
TMS for treatment-resistant depression in adults
This study tests a new type of transcranial magnetic stimulation (TMS) for adults whose depression hasn't gotten better with medication. It compares the real treatment to a sham (inactive) version to see how well it works.
Sunnyvale, CaliforniaAges 22–85 - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
Sunnyvale, CaliforniaAges 18–68 - NCT07294924Recruiting
Predicting depression treatment response with brain imaging
This study uses a special brain-imaging headband to see if it can predict how well people with depression respond to a treatment called accelerated rTMS (a type of brain stimulation). It compares results with people who do not have depression.
Sunnyvale, CaliforniaAges 18–75 - NCT06002100Enrolling by invitation
Predicting depression treatment response with brain imaging
This study uses a special headband (TD-fNIRS) that measures brain activity to see if it can predict how well different depression treatments work. You would be starting a new treatment for depression (like ketamine, SPRAVATO, TMS, or antidepressants) and wear the headband before and during treatment.
Sunnyvale, CaliforniaAges 18–75 - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
San Jose, CaliforniaAges 18–74 - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
San Jose, CaliforniaAges 18–65 - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
San Jose, CaliforniaAges 18 years+
Hear when a new Major Depression trial opens near San Francisco, CA
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Major Depression trials in other cities
Where these studies are running near San Francisco
Institutions with a site for the recruiting major depression studies listed above.
- Stanford University · 7 studies
- Acacia Clinics · 4 studies
- Neurocrine Clinical Site · 2 studies
- Sunwise Clinical Research · 2 studies
- LGTC Group
- Lumos Clinical Research Center
- Seaport Investigator Site
- Stanford Cancer Institute
What taking part in a major depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting major depression studies in California.
Common questions
- Are there major depression clinical trials near San Francisco?
- Yes. We're currently tracking 43 recruiting major depression studies with a site near San Francisco, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a major depression study near San Francisco?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Francisco to take part?
- Not necessarily. These studies have a site near San Francisco, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a major depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New major depression studies open near San Francisco regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.