Clinical trials
Malocclusion clinical trials
Below are recruiting malocclusion clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07692880Recruiting
Digital vs. conventional brace bonding for teens
This trial compares a new digital method for putting braces on teeth to the usual manual method. If you need braces on both top and bottom and have all your adult teeth, this study may help improve how comfortable and fast your treatment is.
FlorenceAges 12–18 - NCT06511219Recruiting
Moving upper back teeth with a 3D-printed brace
This study tests a new 3D-printed dental device to move the upper back teeth backward in teenagers with an overjet (bucked teeth) and a class II bite. It may help correct the bite without removing teeth or using headgear.
Al MansurahAges 13–18 - NCT06516185Recruiting
Comparing two types of clear aligners for tooth movement
This trial tests two different clear aligner designs to see which works better for straightening teeth. It is for people who need braces and have not had orthodontic treatment before.
MadridAges Any age - NCT06517927Recruiting
Long-term dental effects of childhood cancer chemo
This study looks at how chemotherapy given before age 10 affects teeth later in life. Researchers want to know if childhood cancer survivors have more dental problems than others.
BrusselsAges 12–36 - NCT06522607Recruiting
3D Study of Palate Shape After Rapid Palatal Expansion
This trial studies how a rapid palatal expander (a device that widens the upper jaw) affects the shape of the roof of the mouth in growing children. It may help children with a posterior crossbite and a certain stage of dental development.
RomaAges 7–15 - NCT06536335Recruiting
Clear aligner treatment: Comparing two timing schedules
This study compares two different schedules for clear aligner treatment (invisible braces) to see which one feels better for patients. If you have a mild misalignment (Class I) and all your permanent teeth, you may be able to join.
RomaAges 18–40 - NCT05573308Recruiting
Clear aligner study using remote monitoring and AI checks
This trial looks at clear braces (aligner) treatment for straightening teeth, using remote monitoring and computer-guided (AI) check-ins. It may help by making treatment progress easier to track and adjust.
Antioch, IllinoisAges 12–70 - NCT06602518Recruiting
Airway changes after braces for deep overbite
This study looks at how fixing a deep overbite (where top teeth cover most of your bottom teeth) with braces may affect the size of your airway (the space in the back of your throat for breathing). It helps doctors understand if treatment can also help with breathing.
AlexandriaAges 12–16 - NCT06651944Recruiting
Invisalign with jaw advancement aligners
This trial tests Invisalign clear aligners that also help move the lower jaw forward. It may be a good fit if you need both teeth straightening and jaw positioning help.
Richmond, British ColumbiaAges 10–16 - NCT06652230Recruiting
Comparing two ways to place braces for a better smile
This study compares two methods of placing braces to improve smile appearance. It tests if using the natural curve of your smile works better than a standard chart for bracket positioning.
Cairo, ManialAges 11–30 - NCT06662279Recruiting
Hyrax vs. Invisalign palatal expander study
This study compares a traditional metal palatal expander (Hyrax) to a new clear aligner-based expander (Invisalign) for widening the upper jaw in children aged 6-11. It aims to see which device works better and is more comfortable.
Laguna Hills, CaliforniaAges 6–11 - NCT06944860Recruiting
3D-printed vs. traditional twin block braces for kids
This trial compares a new 3D-printed twin block brace to a traditional one for children with a large overbite (overjet ≥7 mm). It checks how well germs stick, how smooth the brace is, and how well it works—plus how children feel about it.
Kuala Lumpur, Kuala LumpurAges 10–14 - NCT07039071Recruiting
Laceback study for orthodontic treatment outcomes
This trial tests whether a technique called laceback improves treatment results for people getting braces. It looks at tooth movement and patient comfort.
Kuantan, PahangAges 15 years+ - NCT07040176Recruiting
Moving upper back teeth back with aligners or mini-screws
This study compares two ways to move the upper back molars backward to fix an overbite where the upper teeth stick out too far. One method uses clear aligners, the other uses tiny temporary screws in the jawbone.
ThessalonikiAges Up to 30 years - NCT07094581Recruiting
How adenoid size affects chewing muscle in children
This study uses ultrasound to see if enlarged adenoids affect the masseter muscle (a chewing muscle) in children. It may help doctors understand how breathing problems during sleep or mouth breathing impact jaw muscles.
Aydin, EfelerAges 3–8 - NCT07115212Recruiting
Bromelain for facial swelling after jaw surgery
This trial tests whether a natural enzyme called bromelain (found in pineapple) can reduce swelling after jaw surgery. You may be eligible if you're having orthognathic surgery and don't have certain health conditions or allergies.
Lexington, KentuckyAges 18–65 - NCT07290790Recruiting
Trimline Aligner Accuracy Study
This trial tests SureSmile clear aligners to see how accurately they fix common bite problems like crowding, spacing, and overbite. You may be able to join if you need mild to moderate orthodontic treatment.
Fresno, CaliforniaAges 18 years+ - NCT07314034Recruiting
Digital full-mouth dental restoration trial
This trial tests a fully digital, face-guided approach to replace missing teeth and fix bite or cosmetic issues. It may help if you need a complete mouth rebuild and are open to a modern digital treatment process.
Shibīn al Kawm, MenoufiaAges 20–45 - NCT07340242Recruiting
3D-Printed Braces vs. MARA for jaw alignment
This trial compares two types of braces (a 3D-printed removable brace and a fixed brace called MARA) to see which works better for correcting a bite problem where the lower jaw is too far back. It is designed for teenagers who are still growing and have a large overbite.
Al Mansurah, Dakahlia GovernorateAges 9–14 - NCT07361172Recruiting
Ready-made vs custom-made braces for jaw correction
This trial compares two types of orthodontic appliances to correct a Class II bite (where the upper teeth sit too far forward). It tests whether a custom-made device works better than a ready-made one for teens.
Al Mansurah, AdakhliaAges 12–16 - NCT07362160Recruiting
Comparing two types of palate expanders for kids
This trial compares a newer clear palate expander to the traditional Hyrax expander in children aged 10-14 with a crossbite. The goal is to see which device works better and is more comfortable.
Baghdad, Al-Rusafa, Bab Al-moadhamAges 10–14 - NCT07676695Recruiting
Jaw Device and Sound Waves for Class II Malocclusion
This trial tests a special jaw repositioning device (Twin-Block) combined with low-intensity sound waves (LIPUS) to help treat a class II malocclusion (when the lower jaw is set back) in children and teens. It aims to improve jaw alignment and joint outcomes.
CairoAges 10 months–1.2 years - NCT07399197Recruiting
Tracking tooth movement after pulling in upper canine
This trial uses 3D imaging to measure bone and root changes when pulling an upper canine that sticks out toward the cheek into its proper position. It may help doctors understand how to treat this condition better.
Sanaa, Sana'aAges 12 years+ - NCT07455656Recruiting
Vitamin D3 or gum massage for faster canine movement with braces
This study tests whether applying vitamin D3 or a special gum massage (corticision) next to the teeth can help move your eye teeth (canines) faster after your upper first premolars are removed for braces. It is for teenagers or young adults who already need that extraction as part of their orthodontic plan.
Cairo, Cairo GovernorateAges 13–20
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Common questions
- Are there clinical trials for malocclusion?
- Yes. Clin2 currently lists 60 recruiting malocclusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malocclusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malocclusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.