Clinical trials
Mental Health Disorder clinical trials
Below are recruiting mental health disorder clinical trials, each written for real people, not researchers. We’re tracking 509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06444256RecruitingPhase 2
Testing a sleep medication for people with stimulant use
This trial tests whether a medication that blocks a brain chemical involved in wakefulness can help people with stimulant use disorder sleep better. If you use cocaine or methamphetamine and have trouble sleeping, this study may be an option.
Houston, TexasAges 18–65 - NCT07390786Recruiting
Family support program after ICU stay
This study tests a collaborative care program for family members of ICU recovery patients, designed to improve mental health support after a loved one's hospitalization.
Charleston, South CarolinaAges 18 years+ - NCT07592195Recruiting
Breathing and aerobic exercise for men in drug recovery
This study tests whether breathing exercises and aerobic exercise (like walking or jogging) improve physical and mental health in men recovering from substance use. You'd attend supervised exercise sessions twice a week for 8 weeks and complete health questionnaires.
LuzhouAges 18–50 - NCT01980147Recruiting
Skills for Wellness program for youth coping with mental health risks
This trial tests a structured skills program to help children and teens (ages 9–21) cope with early mental health warning signs such as anxiety, mood swings, or unusual thoughts. It may help participants build practical coping tools and well-being.
Halifax, Nova ScotiaAges 9–21 - NCT06923722Recruiting
Can eating grapes help protect your brain during stress?
This study tests whether eating grapes every day for a few weeks can reduce the negative effects of mental stress on your brain and blood vessels. If you are a healthy young adult who experiences stress, you may be able to join.
Birmingham, West MidlandsAges 18–40 - NCT06662357Recruiting
Family Connections mental health and substance use support for youth
This trial provides integrated mental health and substance use assessments for children and teens ages 3 to 18. It's designed for families who've been referred by their primary care doctor and have MassHealth insurance.
Cambridge, MassachusettsAges 3–18 - NCT06821230Recruiting
Mindfulness for Parkinson's patients and their caregivers
This study tests whether a dyadic mindfulness program can help both people with Parkinson's disease and their caregivers manage negative emotions. You and your care partner would attend sessions together to learn mindfulness techniques.
Hong KongAges 18 years+ - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT06859060Recruiting
Improving health for people with serious mental illness
This study helps people with serious mental illness like schizophrenia or bipolar disorder who also have chronic health conditions (e.g., diabetes, overweight) get better overall care. It focuses on improving health and wellness through preventive medical care in Puerto Rico.
Mayagüez, Puerto RicoAges 21 years+ - NCT07411222Recruiting
Emotional Eating, Sleep, and Metabolic Health Study
This study examines how emotional eating, sleep quality, and mental state relate to metabolic syndrome (a group of conditions like high blood pressure, high blood sugar, and extra belly fat) in people with stable schizophrenia or bipolar disorder. It aims to help understand and improve overall health.
Bolu, BoluAges 18–65 - NCT04226898RecruitingPhase 2
Synbiotic supplement to lessen schizophrenia symptoms
This Phase 2 trial tests whether a “synbiotic” supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia or schizoaffective disorder. It may help by targeting gut-related immune and inflammation pathways that could affect brain symptoms.
Batlimore, MarylandAges 18–65 - NCT07860294Recruiting
Mental imagery and self-regulation for daily activities in Parkinson's
This study tests whether practicing mental imagery (imagining movements) along with self-regulation techniques can help people with Parkinson's disease improve their daily activities. It aims to see if this training makes everyday tasks easier.
Hong KongAges 18 years+ - NCT05930886Recruiting
Focus groups with diverse parents about child mental health
This study brings together Black and Hispanic/Latino parents or caregivers to discuss what it’s like to seek help for a child’s attention or emotional challenges. Your feedback helps researchers test whether a future treatment and support program would be practical and acceptable for families.
Portland, OregonAges 18–80 - NCT06577779RecruitingPhase 4
Testing Jornay PM for adult ADHD symptoms into the evening
This study tests if Jornay PM, a long-acting ADHD medication, helps control symptoms, focus, and emotions throughout the day and into the early evening in adults with ADHD. It is an open-label study, meaning everyone knows they are getting the medication, and then they are randomly assigned to different observation groups.
New York, New YorkAges 18–60 - NCT05871606RecruitingPhase 1
Breathing nitric oxide during clot-removal for stroke
This Phase 1 study tests whether inhaled nitric oxide (a gas breathed through a ventilator) can improve outcomes in people having a specific kind of emergency stroke procedure to remove a clot from the brain. It focuses on patients who need general anesthesia for the clot-removal procedure and have imaging results that suggest salvageable brain tissue.
Charlotte, North CarolinaAges 18–80 - NCT04877093RecruitingPhase 3
Low-dose clonidine for PTSD nightmares in veterans
This Phase 3 study tests whether low-dose clonidine can reduce PTSD symptoms and especially nightmares in U.S. veterans. You’d be screened for PTSD severity and current treatments, then asked to visit the clinic as scheduled to see if the treatment helps.
Wauwatosa, WisconsinAges 18 years+ - NCT06648642Recruiting
MRI-guided brain stimulation for alcohol use disorder
This study tests whether a new type of brain stimulation, guided by MRI and a robot, can help reduce heavy drinking in people with alcohol use disorder. The treatment is non-invasive and aims to improve brain function related to cravings.
San Antonio, TexasAges 18–65 - NCT07743645Recruiting
Preventing schizophrenia in teens with family history
This study tests whether a program can help prevent schizophrenia and related conditions in young people who have a family history of these illnesses. It focuses on identifying early risk factors and providing support to reduce the chance of developing the disorder.
Houston, TexasAges 9–19 - NCT06158607Recruiting
PrEP adherence help for women with substance use
This study tests a program to help Black and Hispanic women with substance use disorders take PrEP consistently to prevent HIV. The goal is to see if talking with a health coach can improve PrEP use and reduce HIV risk.
Houston, TexasAges 18–60 - NCT05800899Recruiting
Brief counseling program for alcohol-related injuries in Latinxs
This trial tests a culturally tailored, short counseling session for people who are Latinx and have alcohol-related injuries. It aims to reduce health disparities by helping improve treatment access and outcomes after an injury.
El Paso, TexasAges 18 years+ - NCT06419959Recruiting
NightWare app for veterans with PTSD and sleep problems
This study tests a smartwatch app called NightWare that may reduce nightmares and improve sleep in veterans with PTSD. It could also help heart health by improving sleep quality.
Aurora, ColoradoAges 22–88 - NCT05776316Recruiting
Harm-reduction support for adults using opioids
This trial offers harm-reduction services for adults who have been misusing opioids (and sometimes other substances) recently. It’s designed to test support approaches that may reduce risks and improve well-being.
New Haven, ConnecticutAges 18 years+ - NCT07307417Recruiting
Breathing muscle training for obesity
This trial tests if training your breathing muscles can improve respiratory function in people with obesity. It aims to help those with a BMI of 30 or higher.
Wroclaw, Dolny ŚląskAges 30–60 - NCT07227948RecruitingPhase 2
Testing semaglutide for cocaine use disorder
This study tests whether semaglutide, a medication used for weight management, can help reduce cocaine use in people with cocaine use disorder. You may qualify if you have a body mass index (BMI) of 25 or higher and recently used cocaine.
Houston, TexasAges 18 years+
Hear when a new Mental Health Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for mental health disorder?
- Yes. Clin2 currently lists 509 recruiting mental health disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.