Clinical trials
Microbiota clinical trials
Below are recruiting microbiota clinical trials, each written for real people, not researchers. We’re tracking 376 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06122207Recruiting
Probiotic for women with fertility issues and IVF
This study tests whether a probiotic (a pill with beneficial bacteria) can help improve the health of the female genital tract for people with fertility problems who are undergoing IVF. It aims to see if this can improve chances of pregnancy.
LisbonAges 18–45 - NCT05000996Recruiting
Gut microbiome study for people having metabolic surgery
This study looks at your gut bacteria (your “microbiome”) around the time of metabolic surgery. It may help researchers understand how surgery affects gut health and related conditions like diabetes, blood pressure, and cholesterol.
Nashville, TennesseeAges 21–65 - NCT04540432Recruiting
Study how gut bacteria change with juvenile arthritis treatments
This study looks at how the “gut microbiome” (the helpful bacteria in the intestines) changes in children with juvenile enthesitis-related arthritis. It may help doctors understand how different treatment approaches affect gut bacteria over time.
Nîmes, GardAges 6–18 - NCT06037421Recruiting
Bacteria in breast milk of NICU mothers
This study looks at the bacteria naturally found in breast milk. Researchers want to learn more about the germs in milk from mothers whose babies are in the neonatal intensive care unit.
Corbeil-Essonnes, FranceAges 1 hour+ - NCT06030752Recruiting
Fecal transplant for children with autism
This trial tests whether a fecal transplant procedure can improve symptoms in children and teenagers with autism spectrum disorder (ASD) or ASD plus ADHD. Fecal transplant involves transferring healthy bacteria from a donor's gut into the patient's gut to help balance digestion and possibly affect brain function.
Nanjing, JiangsuAges 3–17 - NCT05975541Recruiting
Infection risk in obesity and type 2 diabetes
This study looks at how obesity and type 2 diabetes affect your body's ability to fight infections. By joining, you'll help researchers understand why some people with these conditions get more infections, which could lead to better prevention and treatment.
Novara, NovaraAges 18–65 - NCT05632497Recruiting
Testing gut microbiome changes in adults with anorexia
This study looks at how changing the gut bacteria (microbiome) may affect people hospitalized for anorexia nervosa. You may be eligible if you’re an adult with a very low BMI and meet the study’s timing and health requirements.
VillejuifAges 18 years+ - NCT05758961Recruiting
Study of gut bacteria in adults living in France
This study looks at the types of bacteria in your gut (gut microbiota) by analyzing a stool sample. It aims to better describe typical gut bacteria patterns in France and may help researchers understand links to health.
BobignyAges 18 years+ - NCT05533983Recruiting
Stool transplant plus nivolumab for advanced solid cancers
This study tests whether transferring stool microbiome (“FMT,” stool transplant) along with nivolumab can improve outcomes in people with advanced solid cancers that kept worsening even after anti–PD-1/PD-L1 treatment. It also looks at stool and blood changes to understand why the treatment might work.
SeoulAges 19 years+ - NCT05726396RecruitingPhase 2
Microbiome therapy for steroid-resistant immune colitis
This Phase 2 pilot study tests a “restorative microbiota therapy” (RMT) to treat colitis caused by immune checkpoint inhibitors when standard treatments like steroids are not working. It aims to see if this approach is safe and practical, and may improve diarrhea and gut inflammation.
Brainerd, MinnesotaAges 18 years+ - NCT05740319Recruiting
Test stool transplant to treat irritable bowel syndrome
This trial studies fecal microbiota transplantation, which is transferring stool bacteria from a healthy donor to help rebalance gut microbes. If you have irritable bowel syndrome (IBS) that hasn’t improved after several standard treatments, this study may see whether it reduces your symptoms and is safe.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT04924270RecruitingPhase 2
Capsule stool transfer for newly diagnosed inflammatory bowel or joint disease
This Phase 2 study tests whether taking capsule stool (FMT) is safe and can help people who are newly diagnosed and haven’t started the usual medicines yet. Participants will also start the standard first-line treatment for their condition, and the study will compare safety and outcomes.
OdenseAges 18–75 - NCT05669846RecruitingPhase 2
FMT plus pembrolizumab for advanced lung cancer after prior treatment
This Phase 2 trial studies whether adding fecal microbiome transplant (FMT) to pembrolizumab can help people with advanced, PD-L1–positive non-small cell lung cancer that has returned or progressed after anti–PD-1/PD-L1 therapy. You may be asked to give new tumor tissue and undergo gut procedures, because the study aims to change gut bacteria to boost the immune response.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05646901Recruiting
Study how gut bacteria may affect loss of eating control
This study looks at how gut bacteria and the brain may be involved when people struggle to control eating. It may help researchers understand the body’s signals behind eating control problems.
Girona, GironaAges 30–65 - NCT05514223Recruiting
Testing sperm samples to understand lifestyle, gut, and sperm quality
This study measures “free radicals” in sperm to see how lifestyle and the microbiota (gut/community of microbes) may relate to sperm health. You may be asked to provide a semen sample as part of standard fertility testing, unless certain health factors apply.
Groningen, Provincie GroningenAges 18–55 - NCT05400824Recruiting
Health study in La Réunion
This study looks at how metabolism and infections affect people in La Réunion. Participants will provide consent for genetic analysis and answer health questions.
La Réunion, Saint-PierreAges 18–67 - NCT05333471RecruitingPhase 1/Phase 2
Fecal transplant for chronic bowel inflammation in CGD
This study tests whether transplanting stool microbiome (fecal microbiota transplant) can improve chronic colitis in people with chronic granulomatous disease (CGD). It aims to reduce bowel inflammation and symptoms by changing gut bacteria.
Bethesda, MarylandAges 10–60 - NCT05327790RecruitingPhase 2
Fecal transplant to boost new biologic treatment for ulcerative colitis
This trial tests whether fecal microbiota transfer (a stool-based therapy) can improve outcomes when added to starting a new biologic medicine for ulcerative colitis. It compares fecal transplant versus placebo (a sham treatment) to see if symptoms and inflammation improve faster or more strongly.
Edmonton, AlbertaAges 18–75 - NCT05319067Recruiting
Gut bacteria study in toddlers on long-term reflux antibiotics
This study compares gut bacteria (microbiome) in toddlers who take an antibiotic to prevent urine infections for vesicoureteral reflux, versus other similar children. It may help researchers understand how long-term antibiotic use and reflux affect gut health and future risk.
MontpellierAges 1–3 - NCT05321745Recruiting
Fecal transplant for children with Crohn’s disease
This trial tests whether transferring stool microbes (called fecal microbiota transplantation, or FMT) can improve Crohn’s disease in children who have not gotten better with usual treatments. If you qualify, the study will check symptoms and colon imaging/score changes over the study follow-up.
Wuhan, HubeiAges 2–16 - NCT05200182Recruiting
Brain training to improve control over emotional eating
This study tests a brain training technique (neurofeedback) that may help improve self-control related to emotional eating. If you tend to eat more when stressed or upset, this could help you manage those urges.
RennesAges 18–50 - NCT05054361Recruiting
Study gut immunity changes in children with type 1 diabetes
This study looks at how a type of immune cell (MAIT cells) and the gut (microbiota and gut lining) change around the time type 1 diabetes starts in children. It may help researchers understand why type 1 diabetes begins and how the gut and immune system are connected.
AntonyAges 1–15 - NCT04809688Enrolling by invitation
Study how berries affect metabolism and gut bacteria
This study looks at whether eating Saskatoon berries changes how your body uses energy (metabolism) and how your gut bacteria behave. It’s done in healthy people and may help researchers understand how foods could support overall health.
Winnipeg, ManitobaAges 18–75 - NCT04700579Recruiting
Study lung changes before and after treatment for active TB
This study looks at changes in the lungs and immune system before TB treatment and again after treatment. By sampling lung fluid and comparing it over time, researchers hope to learn signatures that reflect how TB responds to care.
Cape Town, Western CapeAges 18–60
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Common questions
- Are there clinical trials for microbiota?
- Yes. Clin2 currently lists 376 recruiting microbiota studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiota trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiota trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.