Clinical trials
Migraine Headache, With or Without Aura clinical trials
Below are recruiting migraine headache, with or without aura clinical trials, each written for real people, not researchers. We’re tracking 188 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07671703Recruiting
Physiotherapy for migraine relief
This trial tests whether a combination of physical therapy techniques can reduce migraine symptoms. It may help people whose migraines are not caused by other conditions.
Osnabrück, Low SaxonyAges 18–70 - NCT07657377Recruiting
Physical therapy for migraine relief
This trial tests whether physiotherapy (physical therapy) can help reduce migraine symptoms. It focuses on people diagnosed with migraine by a neurologist, excluding those with other headache types or certain health conditions.
AnkaraAges 18–55 - NCT07656922Recruiting
Shoulder muscle function and migraine
This study looks at how the muscles around your shoulder blade work during migraine attacks. It may help find better ways to treat migraine-related shoulder problems.
Ankara, ÇubukAges 18–55 - NCT07646613RecruitingPhase 2
Testing an inhaled migraine medicine for quick relief
This study tests a new inhaled powder form of a migraine medication called dihydroergotamine (DHE) to see if it safely and effectively stops migraine attacks. If you have frequent migraines, this trial might offer you a new treatment option to try.
Phoenix, ArizonaAges 18–65 - NCT07645924RecruitingPhase 3
Elismetrep for fast relief of migraine attacks
This trial tests a new oral medication called elismetrep (K-304) for quickly stopping migraine pain and other symptoms. If you have regular migraines, this could offer a new option that works fast when a migraine starts.
Birmingham, AlabamaAges 18–75 - NCT04925414RecruitingPhase 4
Testing high-flow oxygen for migraine in the emergency room
This trial looks at whether breathing high-flow oxygen in the emergency department can help relieve migraine-like headaches. You may qualify if you are 18+ and are admitted to the ER for a migraine that fits standard diagnostic rules.
NiceAges 18 years+ - NCT07626307Recruiting
Migraine Screening Tool to Guide Physical Therapy Referral
This study tests whether a simple assessment tool can help neurologists decide which migraine patients would benefit from physical therapy. You'll be evaluated by both a neurologist and a physical therapist to see if the tool correctly identifies patients who could improve with hands-on treatment.
MilanAges 18–70 - NCT07616128RecruitingPhase 2
Testing EVO756 to prevent migraines in adults
This study tests a new medication called EVO756 to help prevent migraines in adults who haven't had success with other preventive treatments. Researchers want to see if this new drug can reduce how often migraines happen.
Chandler, ArizonaAges 18–64 - NCT07609914RecruitingPhase 4
Safety study of an extra dose of rimegepant for migraine
This study tests whether taking an additional dose of rimegepant (a migraine medicine you may already use) is safe and helpful for adults with migraine. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist—a type of medicine that blocks a protein involved in migraine pain.
Canoga Park, CaliforniaAges 18 years+ - NCT07579481Recruiting
Vortioxetine for Depression with Migraine
This study tests whether vortioxetine, a depression medication, can help people who have both depression and episodic migraine (recurring headaches). You'd take vortioxetine for depression while researchers track how it affects both your mood and migraine symptoms.
Rome, LazioAges 18 years+ - NCT07571889Recruiting
Numbing spray to reduce Botox injection pain for chronic migraine
This study tests whether a numbing spray applied inside the nose before Botox injections can reduce injection pain in people with chronic migraine. The goal is to make the treatment more comfortable without affecting how well it works.
East Providence, Rhode IslandAges 18 years+ - NCT07553533Enrolling by invitation
Temporary Nerve Stimulation for Headache Relief
This trial studies a temporary nerve-stimulation device placed near the back of your head to treat chronic headaches. The device sends mild electrical pulses to help reduce headache pain over 60 days, and your doctor has already decided this treatment is right for you as part of your regular care.
New Haven, ConnecticutAges 18 years+ - NCT06735768Recruiting
Daily magnetic brain stimulation to prevent migraines
This study tests a type of magnetic brain stimulation (repetitive TMS) given daily at home to prevent migraines. It may be an option if your migraine medications aren't enough or you want a non-drug treatment.
Vienna, State of ViennaAges 18–65 - NCT07508410Recruiting
Mulligan vs Myofascial Release for Neck-Related Headaches
This study compares two hands-on therapy techniques—Mulligan mobilization and myofascial release—to see which works better for headaches that start from the neck. If you have neck pain on one side and headaches that get worse with movement, this trial may help you find relief.
KonyaAges 18–65 - NCT07515456Recruiting
Comparing Three Medications for Spinal Headaches
This study tests three different medications—theophylline, sumatriptan, and gabapentin—to see which works best for headaches that occur after a spinal procedure. You would receive one of these treatments and be monitored to see how well it relieves your pain.
Tanta, El-GharbiaAges 21–50 - NCT07496034RecruitingPhase 3
Gou-Teng-San for frequent migraines
This study tests a Chinese herbal formula called Gou-Teng-San (GTS) for preventing episodic migraines. It is for adults who have frequent migraines but have not tried many prevention medicines.
Taichung, SouthAges 18–70 - NCT07493434Enrolling by invitation
Can essential oils help with migraine pain?
This trial tests if inhaling essential oils can reduce pain in people with migraine. You may join if you have migraines and are not allergic to essential oils.
São Paulo, São PauloAges 18–60 - NCT06322407Recruiting
Ultrasound-guided neck injection for treating chronic migraine
This study tests whether a nerve block injection near the neck (called stellate ganglion block), guided by ultrasound, can reduce chronic migraine pain. It may be a good option if you have chronic migraine and haven't found relief from standard preventive medications.
Beijing, Beijing MunicipalityAges 18–65 - NCT07479082Recruiting
Ear nerve stimulation for headache after aneurysm coiling
This trial tests whether a gentle electrical device placed on your ear (called transcutaneous auricular vagus nerve stimulation) can help prevent or reduce headaches that sometimes happen after a procedure to treat an unruptured brain aneurysm. If you're scheduled for stent-assisted coiling or flow diverter treatment, this study may offer a non-drug option to manage post-surgery pain.
Beijing, Beijing MunicipalityAges 18–80 - NCT04748601RecruitingPhase 4
Qudexy XR to help prevent migraine in kids ages 6 to 11
This study tests whether Qudexy XR can reduce migraine headaches in children ages 6 to 11. It looks for kids who are having frequent, disruptive migraine attacks and checks safety with careful medication rules.
Birmingham, AlabamaAges 6–11 - NCT03781128RecruitingPhase 2
LSD for cluster headaches in a clinical study
This Phase 2 study tests whether a supervised dose of LSD (or a placebo) can reduce cluster headache attacks. It’s for people whose cluster headaches respond to oxygen, and who can safely pause certain medications and substances around the dosing day.
BaselAges 25–75 - NCT06796725Recruiting
Study of TMS for migraine guided by brain imaging
This study tests whether repetitive transcranial magnetic stimulation (rTMS), guided by magnetoencephalography (MEG), can help people with frequent migraines or tension-type headaches. If you have headaches 15 or more days per month, this treatment might reduce your pain.
ShanghaiAges 15–50 - NCT07360782Recruiting
Personalized nerve treatment for medication overuse headache
This trial tests a treatment called personalized pulsed radiofrequency, which uses gentle electrical pulses on a nerve at the back of your head to help reduce headaches caused by using too much pain medication. It is designed for people who have been diagnosed with Medication Overuse Headache and want a non-drug option.
AnkaraAges 18–65 - NCT07354126Recruiting
Flunarizine vs. propranolol for migraine in children
This trial tests two medicines—flunarizine and propranolol—to see which one works better for preventing migraines in children ages 8 to 15. If your child has frequent migraines that affect their daily life, this study may help find a treatment that works for them.
Lahore, Punjab ProvinceAges 8–15
Hear when a new Migraine Headache, With or Without Aura trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for migraine headache, with or without aura?
- Yes. Clin2 currently lists 188 recruiting migraine headache, with or without aura studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine headache, with or without aura trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine headache, with or without aura trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.