Clinical trials
Migraine Headache, With or Without Aura clinical trials
Below are recruiting migraine headache, with or without aura clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05176392Recruiting
Stimulation treatment plus therapy for post-injury headaches
This study tests whether a noninvasive brain stimulation treatment combined with therapy can reduce long-lasting headaches after a mild brain injury. You might be a good candidate if your headaches started after the injury and have continued for months.
San Diego, CaliforniaAges 18–65 - NCT06549270Recruiting
Biochemical study of migraine patients
This trial looks at the chemical changes in the blood of people with migraine. It aims to better understand the disease and may help find new treatments. You may qualify if you have episodic or chronic migraine and have not tried CGRP-targeting drugs.
PaviaAges 18–75 - NCT06562413Recruiting
Finding New Biological Clues in Hard-to-Treat Migraine
This study looks for new biological markers in people whose migraines don't respond to standard treatments. It aims to better understand why some migraines are hard to treat and may help guide future therapies.
PaviaAges 18–75 - NCT06562400Recruiting
New treatments for resistant migraine
This trial is testing new approaches for people whose migraines haven't improved with multiple preventive treatments. The goal is to find better options for those with hard-to-treat migraine.
PaviaAges 18–75 - NCT06938178Recruiting
EEG markers of mindfulness for migraines
This trial uses EEG (brain wave) tests to see if mindfulness therapy, added to your regular treatment, helps people with frequent migraines (8–14 headache days per month). You will have brain scans before and after mindfulness sessions to look for changes that show it's working.
MilanAges Any age - NCT04628429Recruiting
Study CGRP blocker effects on migraine and body nerve function
This study tests a CGRP-blocking antibody to see how it affects migraine symptoms and the body’s automatic (involuntary) nerve functions. It may help people with migraine who have already tried several preventive medicines.
ViennaAges 18–64 - NCT06625060RecruitingPhase 2
Study of IPN10200 for preventing migraine in adults
This trial tests a new medicine called IPN10200 to see if it can prevent episodic or chronic migraine. It is for adults who have had migraine for at least a year and have tried at least one preventive treatment before.
Birmingham, AlabamaAges 18–80 - NCT07136740Recruiting
Biofeedback for preventing tension headaches
This study tests whether a smartphone app that teaches you biofeedback (a way to relax muscles using sensors) can help prevent tension headaches. You will use the app at home to practice techniques and track your headaches.
NamsosAges 18 years+ - NCT06839118RecruitingPhase 3
Botox for headaches after head injury
This trial tests if Botox injections can reduce headache days in people with persistent headaches after a mild head injury. It may help if you have headaches at least 15 days a month.
Glostrup MunicipalityAges 18–80 - NCT06882122Recruiting
Atogepant for episodic migraine: brain and body effects
This study tests a daily pill called atogepant to see how it affects the brain and body in people with episodic migraine. It may help if you have 8 to 14 migraine days a month and haven't tried CGRP treatments before.
Pavia, PAVIAAges 18–70 - NCT06893874Recruiting
Comparing migraine preventives chosen by a computer
This trial tests whether a computer algorithm can help pick the best migraine prevention medicine for you. You'll try one of several common preventives and track your headaches.
TrondheimAges 18–99 - NCT07059546Recruiting
Studying sensitivity to adrenomedullin in chronic post-traumatic headache
This trial tests whether people with long-term headache after a mild head injury have an abnormal reaction to a substance called adrenomedullin, which may play a role in causing headaches. You will receive adrenomedullin and a placebo in separate sessions to see how your headache responds.
Glostrup MunicipalityAges 18–65 - NCT07233941Recruiting
Cognitive and psychological study in migraine patients
This study looks at thinking abilities and psychological factors in people with migraines. It aims to understand how migraine affects memory, attention, and emotions.
MilanAges 18–65 - NCT07301008RecruitingPhase 4
Rimegepant to prevent predictable trigger-induced migraines
This trial tests whether a medication called rimegepant can prevent migraines when you take it before a known trigger (like exercise or stress). It is for people who get migraines often and can predict when one might happen.
McLean, VirginiaAges 18 years+ - NCT07487649Recruiting
Treatment response in headache from medication overuse
This trial looks at how well people respond to treatment when their headaches are caused by taking too much pain medicine. It may help if you have migraines or tension headaches and you use triptans or NSAIDs often.
EdirneAges 18–65 - NCT07567300Recruiting
Understanding Pain Patterns in Migraine and Neck or Back Pain
This study explores how migraine headaches, neck pain, and lower back pain may share similar pain mechanisms in the body. Researchers will ask you questions to understand your pain patterns and help identify connections between these conditions.
Gaziantep, MerkezAges 18–65 - NCT07573488Recruiting
Sleep, Stress, and Migraine: Observation and Training Study
This study explores how sleep and stress affect migraine headaches and tests whether improving sleep habits can help reduce migraines. You'll be observed and taught strategies over several months while researchers track your headaches and sleep patterns.
ZurichAges 18–65 - NCT07018700RecruitingPhase 3
Study on Xeomin shots to prevent migraines
This trial tests if Xeomin injections can help prevent episodic migraines in people who have 6 to 14 migraine days per month. It's for those under 50 when their migraines started and who can tell migraine from other headaches.
Chandler, ArizonaAges 18 years+ - NCT07018713RecruitingPhase 3
Testing Xeomin injections to prevent chronic migraine
This trial tests if Xeomin (a botulinum toxin injection) can help prevent chronic migraine. If you have frequent migraine headaches, you may be able to join.
Chandler, ArizonaAges 18 years+ - NCT05125302RecruitingPhase 3
Ubrogepant for acute migraine relief in kids and teens
This study tests how safe ubrogepant is and whether it helps treat an individual migraine attack in children and teens. It focuses on measuring side effects and whether headaches improve 2 hours after taking the study medicine.
Huntsville, AlabamaAges 6–17 - NCT04965675RecruitingPhase 3
Eptinezumab for teens with chronic migraine
This trial tests eptinezumab, a preventive medicine, to reduce headache frequency in teens with chronic migraine. It may help your teen if they have frequent migraine days despite usual care.
New Haven, ConnecticutAges 12–17 - NCT05897320RecruitingPhase 3
Eptinezumab trial for kids with episodic migraine
This Phase 3 study tests eptinezumab to reduce migraine attacks in children who have episodic migraine (not daily chronic migraine). It may help by lowering the number of headache days and migraine days over time. You must complete a headache diary during screening to be considered.
Stamford, ConnecticutAges 6–17 - NCT07776275Recruiting
Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls
Istanbul, SefaköyAges 25–60 - NCT07645924RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
Birmingham, AlabamaAges 18–75
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Common questions
- Are there clinical trials for migraine headache, with or without aura?
- Yes. Clin2 currently lists 198 recruiting migraine headache, with or without aura studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine headache, with or without aura trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine headache, with or without aura trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.