Clinical trials
Multiple sclerosis clinical trials
A condition in which the immune system attacks the protective covering of nerves. We’re tracking 428 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06062693Recruiting
Home Hand Training with Sensors for Better Dexterity
This study tests a new home-based hand training system using sensors to help improve hand movement and dexterity in people with Parkinson's, multiple sclerosis, or stroke. It also includes healthy volunteers for comparison.
LucerneAges 18–99 - NCT06218927Recruiting
Stem cell transplant and bladder function in MS
This study looks at whether a stem cell transplant (AHSCT) can improve bladder problems and quality of life in people with multiple sclerosis (MS). It compares people getting this treatment with those on standard MS therapy.
Ostrava, Moravian-Silesian RegionAges 18 years+ - NCT06267781Recruiting
MS progression and immune cells after bone marrow transplant and other therapies
This study looks at how well different treatments, including bone marrow transplant, alemtuzumab, ocrelizumab, and ofatumumab, work for people with relapsing-remitting MS who have active disease. It will help doctors understand which therapy might slow disease progression best.
MilanAges 18 years+ - NCT06195800Recruiting
Biomarkers after stem cell transplant for neurological diseases
This trial looks at biomarkers (biological signs in your blood) in people with immune-mediated neurological diseases. It compares those getting a stem cell transplant to those on high-efficacy MS treatments to understand how these therapies work.
Sheffield, EnglandAges 16 years+ - NCT04933552Recruiting
Safety study of Mayzent during pregnancy for babies
This study follows pregnant people with multiple sclerosis (MS) who took Mayzent (siponimod) to understand safety for pregnancy outcomes. It compares them with other groups to see whether there are any differences in birth results.
La Jolla, CaliforniaAges Any age - NCT07852156Recruiting
Cooling during inpatient rehabilitation for people with multiple sclerosis
This trial tests whether cooling the body during a stay at a rehabilitation clinic helps people with multiple sclerosis (MS) feel better and recover more effectively. If you have MS and find that heat makes your symptoms worse, this study may help you manage your symptoms during rehab.
Valens, Canton of St. GallenAges 18 years+ - NCT06450977Recruiting
MIND diet study for people with multiple sclerosis
This study tests whether the MIND diet (a combination of the Mediterranean and DASH diets) can help people with multiple sclerosis (MS). Participants will receive meals and be monitored remotely, so you can take part from home.
Urbana, IllinoisAges 18–64 - NCT04114994Recruiting
Memory testing study for adults 50 and older
This study checks how people’s thinking and memory change over time using a specific cognitive test. It may help researchers understand patterns of memory change and supports future research on brain health.
Miami, FloridaAges 50 years+ - NCT07788859Recruiting
Testing dual-task walking tests in multiple sclerosis
This study looks at how well three different dual-task tests (doing two things at once while walking) work for people with multiple sclerosis. It aims to find reliable and valid ways to assess walking and thinking in MS.
GaziantepAges 18–65 - NCT06541626Recruiting
Study of CNS inflammatory demyelinating diseases
This study follows people with certain inflammatory conditions of the brain and spinal cord (like MS, NMOSD, or MOGAD) to learn more about their disease. If you join, you will help researchers understand these conditions better.
Guangzhou, GuangdongAges 18–65 - NCT07779460Recruiting
Comparing two multiple sclerosis medicines in everyday practice
This study compares how well two medicines, Kesimpta and Ocrevus, work for people with multiple sclerosis when used in real life. It looks at patient records to see which treatment might be more effective.
East Hanover, New JerseyAges 18–100 - NCT07783074Recruiting
Fatigue study using digital outcomes in multiple sclerosis and long COVID
This study is investigating fatigue using digital outcomes in people with multiple sclerosis, long COVID, and healthy volunteers. Participants must own a smartphone, be fluent in German or English, and be willing to provide informed consent. Exclusion criteria include having taken certain medications recently, being pregnant or lactating, or having additional health conditions that could affect fatigue or the autonomic nervous system.
Basel, BaselAges 18–65 - NCT07768761Recruiting
Electrical stimulation exercise for lower limb paralysis
This trial tests whether a muscle exercise program using electrical stimulation can help people with paralysis in their legs. It may improve muscle strength, blood flow, or other health benefits.
Cleveland, OhioAges 18 years+ - NCT07753928Enrolling by invitation
Tracking brain changes in multiple sclerosis
This study looks at how certain brain changes relate to disability in people with multiple sclerosis (MS). It aims to see if measuring brain volume loss can help predict disease progression, which might help tailor treatments.
DresdenAges 18–55 - NCT06474520Recruiting
Bovine gallstone extract for inflammatory brain disease
This trial tests a natural substance called Calculus Bovis Sativus (CBS) to see if it helps people with certain inflammatory brain conditions like multiple sclerosis, neuromyelitis optica, MOGAD, or ADEM. The goal is to find out if it is safe and effective.
Wuhan, HubeiAges 18 years+ - NCT07738978Recruiting
Movement and health study for paralysis
This study is looking at ways to improve movement and health for people with paralysis from conditions like spinal cord injury, stroke, traumatic brain injury, or multiple sclerosis. It involves exercises and may include electrical stimulation to help your leg and trunk muscles work better.
Cleveland, OhioAges 18 years+ - NCT04635436Recruiting
Split-walking training for one-sided leg weakness when walking hurts
This trial tests whether a “split gait” walking training method can improve walking balance and how you move when you have one-sided leg problems and pain or limitations when walking. It may help reduce walking difficulties by training your stepping pattern safely.
Milan, MIAges 18–70 - NCT07720765Recruiting
Using eye scans to study brain diseases
This trial uses a type of eye scan (OCT) to look at the retina in people with brain conditions like multiple sclerosis, Alzheimer's, Parkinson's, or migraines. It aims to see if these scans can help doctors learn more about the disease and monitor it over time.
Milan, MilanoAges 18 years+ - NCT03850301Recruiting
Testing a brain inflammation target using an investigational medicine
This study tests whether a medicine that targets a specific brain inflammation marker (TSPO) can help in people with certain types of multiple sclerosis. It focuses on safety and whether the target can be measured and influenced during treatment.
London, EnglandAges 35–65 - NCT07710105Recruiting
Ocrevus for MS: A Real-World Study
This study will follow people with multiple sclerosis (MS) who are starting or restarting a treatment called Ocrevus (ocrelizumab). The goal is to understand how well it works in real life over 12 months. Participants will receive Ocrevus as part of their usual care and complete surveys about their experience.
Chicago, IllinoisAges 18 years+ - NCT04607174Recruiting
Test knee muscle activation in people with nerve or movement disorders
This study checks how well your knee muscles “turn on” during guided, controlled knee movements. It may help researchers understand movement problems and improve testing or therapies for neuromotor (nerve/movement) disorders.
Milan, MIAges 18–70 - NCT04561557RecruitingEarly Phase 1
Cell therapy for relapsing nervous system autoimmune diseases
This early-phase trial tests CT103A “CAR-T” cell therapy to treat certain relapsing or treatment-resistant autoimmune diseases that affect the nervous system. It aims to see whether the cells are safe and may help reduce disease activity when standard treatments haven’t controlled symptoms.
Wuhan, HubeiAges 18–75 - NCT07673354Enrolling by invitation
Spinal cord stimulation at home for hand and arm function in MS
This trial tests if gentle electrical stimulation can help improve hand and arm function in people with multiple sclerosis. You will use a small device at home with support from a caregiver.
Seattle, WashingtonAges 18–70 - NCT07653984Recruiting
Study on immune diseases in women of childbearing age
This study follows women with certain immune disorders affecting the nervous system (like multiple sclerosis or myasthenia gravis) to understand how these conditions affect reproduction. Healthy women planning pregnancy are also included for comparison.
Guangzhou, GuangdongAges 20–55
Hear when a new Multiple sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for multiple sclerosis?
- Yes. Clin2 currently lists 428 recruiting multiple sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a multiple sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a multiple sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Multiple Sclerosis, Relapsing-Remitting
- Multiple Sclerosis (MS) - Relapsing-remitting
- Multiple Sclerosis, Secondary Progressive
- Relapsing Multiple Sclerosis
- Multiple Sclerosis, Primary Progressive
- Progressive Multiple Sclerosis
- Multiple Sclerosis (MS) Primary Progressive
- Multiple Sclerosis (MS) Secondary Progressive
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.